Description | Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MDTCWASSNIERSNRAYLCYKFNGTQVKATVRTPKQQQSQTRLQKRRRFIRYIMELSPINQIEDRKPTLTADGLVQTSNSPFEPTAAATTTTTTAAAAAAATATAATTTTTTVSQETQTSNGIGIGGPLTVDQLDIEILPIIYDIVRCVEKDPLENAVKLRESQDCNHKIFELQKRFDSAREQIKQLPGIDYNKEEQLQRLELLRSQLKLKQQLIRKYKDTEF |
Length | 223 |
Position | Middle |
Organism | Drosophila virilis (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.619 |
Instability index | 59.28 |
Isoelectric point | 9.01 |
Molecular weight | 25244.32 |
Publications | PubMed=17994087 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25186 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 34.67| 10| 15| 85| 94| 1 --------------------------------------------------------------------------- 85- 94 (19.53/ 9.30) TA.AATTTTTT 102- 112 (15.13/ 6.05) TAtAATTTTTT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LIRKYK 2) QTRLQKRRRFIRYIMELSPIN | 214 40 | 219 60 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab