<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25177

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPTPLPLEQMPGANAGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELMVLAELLPRKTDMERKVEIYAYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVALTVMGDSPNVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLVVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNTDRSKLPALLSELRYWITHRRCEKTLQHLPATATETLPFLTLPEQELLQPGRHKIYVKLHRHPNIILVVQLKEKPAMPNEMEYTFHLGFVVFQKDENDVVDDSAKQLVSIVAQPPSEIPKLYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDILAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFLNLAQTLAKYRIPHSGLQVEANATSLVLKILALPQPGTNNQATTATGEQKPTPAPSTSSALPKIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSTHQKELGSRRTINLTYEQANHDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLRNKRLSLGDMLVVKSYTYANLLLGYGPKKEVTCNIYWSVQSHGFRLTFVGGISAVNAHSMMRDQLAQHLNQQHSLTTIAHILHETYNPMSSIAKLPVLPLLGIPRPQVPVLSFCMLPQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVIEEFTPIQGLKAFLSKYVDESAVYRGRAPHDDDNPLSPMGLEDNFGGPSSVTGVSAGGSSPFLGAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGGGGAQSHANFNLTSPPAPHMPHPSPGGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGGPGVGAADRNVTRGTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVADMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVMLNQLHMQSLHLKVTQLPPMPDKPTFQLSPDDLLVIEQYFDTRVAAPPYRPNALHSICRLLNLPGHVLKDFVQIMRLEMKPELGGDQLKWTVQMCMRMSPSAMPIVPIGSACVVLGRMKILFFLHITRIPYNGKDWKDSPSLVLPIVHDIATNLTQVAERREQVQSPTMSAASALLRRFADFGVQQNQCSLFPAVTELLTNLQITTDLPPPPPNQPIGPPVGVGVGVGVGVGVVGSSPNTMMPMQQLQPQVGHGPQLGPNPGGPQ
Length1537
PositionTail
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.247
Instability index53.95
Isoelectric point8.46
Molecular weight170910.88
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25177
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     255.20|      39|      39|    1030|    1068|       1
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 1005- 1034 (41.06/12.03)	.........PLSP..MGLE...DNFGGPSSVTGV.SAGGSSPFL.G
 1035- 1074 (70.90/25.78)	AG....MRGPQSPRDSGLRF.PAPHTPPSSSNPH.TPASPHPSAgG
 1075- 1109 (48.70/15.55)	GG....GGGAQSHANFNLTSpPAPHMPHPSPGGL.MPSSP......
 1143- 1177 (54.87/18.39)	AN....NNWPGSP.....SM.PRPSPRPGQSPEHkSTGGGGPGV.G
 1178- 1215 (39.68/11.39)	AAdrnvTRGTLN.RPWAGAV.PTLLTHEALETLC.RP.SPHP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     447.57|     108|     190|    1231|    1338|       2
---------------------------------------------------------------------------
 1231- 1338 (185.29/106.13)	LGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVM..LNQLHMQSLHLKVTQLPPMPDKPTFQLSPDDLLVIEQYFDTRVAAPPYRPNALHSICRLLNLPGH
 1349- 1424 (105.37/56.68)	...LEMKPELGGD.QLKWTVQMCMRMSPSAMPIVPIGSAC.VV..LGRMKIL.FFLHITRIP..YNGKDWKDSPSLVLPIVHDIAT........................
 1426- 1525 (156.91/88.57)	LTQVAERRE...QVQS.PTMSAASALLRRFADFGVQQNQCSLFpaVTEL.LTNLQIT.TDLPPPP..PNQPIGPP..VGVGVGVGVGVGVVGSSPNTMMPMQQLQPQVGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.00|      27|     185|     477|     507|       3
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  477-  507 (43.92/36.12)	RYWITHrrceKTLQHLPATATETLPFLTLPE
  642-  660 (24.56/ 9.77)	............LAHVVAMCDEKIPFLNLAQ
  664-  690 (42.52/24.44)	KYRIPH....SGLQVEANATSLVLKILALPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.22|      25|      93|      63|      87|       4
---------------------------------------------------------------------------
   44-   57 (14.43/ 6.19)	...........RTYHELMVLAELLP
   63-   87 (40.00/32.89)	ERKVEIYAYAARTRHLFTRLNALVK
   96-  112 (19.78/11.78)	DKSSQIMSFLDKQNMLF........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     411.07|     102|     103|     150|     251|       5
---------------------------------------------------------------------------
  150-  191 (39.48/18.18)	....................................................................NRLPTCIRERIVP.P..DAI.TPAEK.....RQTLLRLNQVIQHRLVTGKL
  192-  295 (155.16/95.31)	LPQMR.EFRIRNGRVTFEVKHEFSVALTV..MGD.SPNVPWRLLDIDVLVEDKETGDGKSLVH.PlqvNYIHQLIQARLVEnP..NAL...SEV.....YNCLHYFCQSLQLEVLYTQT
  296-  389 (104.01/61.21)	L.RLN.YERLDDNNITVE.EYVPGVKLTVsyWRDlKSELGYRL...TVQSDPSEIGRPLVVVHvP..................slGAK.ESAEVadravRSEHLSMERLIVHTVYIRSV
  392-  473 (112.41/66.81)	LSDLKlEFQAFLKDVDFNLQGTPAI.LTV..PVL.SPCL..RAEQIHITI.DTHTGMFRCHV..P...KHLDCPITEEM...Q..DCLnTDRSK.....LPALL...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.09|      10|      87|    1133|    1142|       8
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 1113- 1122 (21.90/ 8.86)	QPSPHMVHSP
 1133- 1142 (20.19/ 7.66)	QDSPFTAMSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25177 with Med14 domain of Kingdom Metazoa
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