<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25174

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCMQADMLCVWRRVQSTKQDNTDPNALNFEITTSTTVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLKIAANQSLWNGTWKGELTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASGQTSGTARAQQDAASAGTATLPAGSPLLEASGVAEKSASASAAAAAATPTQARKVMLAPFGIAAILTGNSYKASDPMAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFAELHKANDQAAAAAAAAATPAATQAAASAKDSRKATTQAISALERLTFQPYYDQRPTSGFTFNTNNTHIPATAAIEMPERAWQDCIMNTLHVDAAAAAAAAAAAAAAEEDENKQTDSKQHVQQQIQQQQQQQQQQKQRQKLWNFVDPMQKAPCICTKHLNVGSASSGGSSSTPCQGGGASSTYSRNTQLGDPTVAAATAAAAASSSVGSPATPAPSPHPLSNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPTYAEHGNAAGGGGSQSLNAAPGSVPQQPATPTPATAGAAATTTATTTTSATAAGTGTAGAATGAGAGAGGATQCGTISVKKLEMQQQAPQQVLAIKQEPGLARISQVQQQQQQQVPLASSALEAVTNLFNLYKPPQLTLKDGDSVYDEEWLKDVYDFSFQETWDNLPVKRPKLNESAKQRRPRYARNLYEGHTHFKPLMPSPGSVYGPLLSIEGSAAALGAAGEGSSSGGGGGGLVGIAGGAGAGAGGAYGGASSADEADNALGGSGSGSGSGNMTATTTGNSFFQGLDIKTEPGLHSPCKESKSTSTAGSGSAGNNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVSNTIDELKRSTAVASAVVAAVVASSGAGSIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTNNSSSTTTNVGVAVGLGVVLKMVKQEYSVELGSPVEEPIDDWSYVYRPPQQEKFVGSSRYAPLTNLPSQTQPPLQIPANCYYNPTWSHSQKSRAATLAKAAAAQQQQQQLQKHQQLQQRIQQHQQLQQQHQQQQLQLQQQQQQQHKHQQLHELLSAGPRTPMNAAMPSPSTTTTATTTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPIPSPGGPGVVPFPRSSPMHLGGMRQTPTHPPPPYPYELAAASPATSTSSYLNKQYNSQEPPGHPHTPQSVHHVMFGPMSAGAGGSGGAGAGLMPAGDGSKLAMMQYSGGGAGSTGLGSSSSSSVAAAAAAAAAAMSLLQELPEVNSVLINILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGLYVPLPGSSFNPFPSQRLLNSHPAGTPYNPFGGSASGGGGGGGGGGGGMRMISAFGGGLDSSPVAALSGAGSVHHGHGPNGGSSSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDELEITGIVDDPARHKQPTLLSLIQSLCRKGNNNHNHNHNNKSVNEPVGKELEKLTTTTTTTSGQQQQQQQLEQLAHAIFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRLFGQNSASLASIANVLEFTDAHDVVSLALEQARLAFESQRMDMNMLEFGHNNHHGQQHNPHQHSQHPHHPHQPHPAQHSQQLTAFQAAPALRQKLLVLGSSRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQSAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVAASTRTYFRELSSTYEMCKLGRHTPIRGWEGVLQVGTEREAPLTPLDDWLRTLDHAPLAEQIRRYAVAFLYQLAPYLSRVPGDKTLLNPPDASASGSHSTKAPGAVPPSAAEHPHEPVIKLEPGTEPTPATQSSSNSSSGGAGGAGQEQDSKADVKAGGDSKPALVLGDPLGMGETLEDINPSAIVLYVVNPFTFASDSFELERLALIALLRCYAELLKAVPDSVRAQMNIQIISLEAIMELGPCGNRRRFSDEIKCLALNIFSQCRRHLVHAQPVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRAAGSMHGQNETRYSVMYCNYCLSEDQSWLLATATDERGELLEKVCINIDVPNRARRRKAPARYVALRKLMDFVMGLISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCASFTRQFQNEPQVDDDFIFGEEEGNEDFSDADIGDLFWDSAHMDRVSNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPNIQIADDILNSTNAHQSANDHPLDSTLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2698
PositionMiddle
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.409
Instability index52.03
Isoelectric point6.09
Molecular weight288769.10
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25174
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.30|      21|      21|    1203|    1223|       1
---------------------------------------------------------------------------
  483-  503 (38.15/15.98)	TDSKQHVQQQIQQQQQ......QQQQQ
  758-  777 (33.65/13.34)	IKQ.EPGLARISQVQQ......QQQQQ
 1208- 1234 (35.50/14.42)	LQKHQQLQQRIQQHQQlqqqhqQQQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.18|      24|      82|     376|     402|       2
---------------------------------------------------------------------------
  226-  249 (33.21/ 8.50)	AEAAAAFAAASGQTSGTARAQQDA
  377-  400 (37.64/12.14)	QAAAAAAAAATPAATQAAASAKDS
  879-  894 (19.33/ 8.79)	..AAALGAAGEG......SSSGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     447.58|      76|     152|    1358|    1437|       3
---------------------------------------------------------------------------
  530-  625 (45.30/12.77)	GSASSGGSSSTPC.Q..GGGASStysrnTQLGDPTVA...........................................................aataaaaasssvgsPATP.APSphplsnsahsqptsvpPAEQLLNMS.....PHA....ptsvsnlqQPP...TP...................................
  635-  684 (36.36/ 8.64)	..............................................................................................................PA....PT................PTDQHDNKS.....ITA............SPYvhqTP.SVEpptyaeH.......G.NAAGGGGSQslNAAP
  685-  731 (62.24/20.96)	GSVPQQPATPTPA....TAGAAA.....TTTATTTTS....................................................................................................................................................ataaGTGTAGAATGA..GAGA
  910-  978 (81.36/29.80)	GG..AYGGAS.......SADEAD.....NALGGSGSG...................................................................sgsgnmTATTTGNS................FFQGLDIKT.....EPG............L.H...SPCK................ESKSTSTAGSG..SAG.
 1257- 1322 (57.04/18.56)	.RTPMNAAMPSP....ST..........TTTATTTVP........................................................................qPLSS.GGS..................QLLLNQLncpqaPPGssmqqlmqragmSP....IP.SP.............................GGP
 1323- 1405 (83.40/34.54)	GVVPFPRSSP...........................................................................mhlggmrqtpthppppypyelaaasPATSTSSY................LNKQYNSQE.....PPG............HPH...TPQSVH......HvmF....GPMSAGAGGSG..GAGA
 1406- 1437 (21.61/ 7.93)	GLMPAGDGSKLAMmQySGGGAGS.....TGLGSSSSS.........................................................................................................................................................................
 1511- 1551 (60.26/19.68)	.....................................svaaaaaaaaaamsllqelpevnsvlinillydtalnvfrdhnfdsssvcvcnadtqkignirgadsglyvplPGSSFNPF................PSQRLLNSH.....PAG............TPY...NP.............F....GGSASGGGGGG..GGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.90|      11|     461|    1340|    1350|       4
---------------------------------------------------------------------------
 1340- 1350 (26.36/12.42)	QTPTHPPPPYP
 1812- 1822 (27.54/13.37)	QHPHHPHQPHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.38|      12|      23|    1072|    1094|       6
---------------------------------------------------------------------------
 1072- 1087 (18.41/10.65)	SHEqqhpNSSPCQTDV
 1097- 1108 (20.98/12.27)	TTN....NSSSTTTNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.61|      21|      23|    1127|    1149|       8
---------------------------------------------------------------------------
  782-  798 (19.29/ 6.84)	....SSALEAVTNLFNLYKPP..
 1127- 1149 (35.19/28.36)	VelGSPVEEPIDDWSYVYRPPQQ
 1153- 1173 (38.13/24.00)	V..GSSRYAPLTNLPSQTQPPLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.83|      20|      24|    1604|    1627|      10
---------------------------------------------------------------------------
 1604- 1627 (27.73/34.27)	GYVDDDPVECTcGfsaVVNRRLSH
 1630- 1649 (36.09/24.99)	GLFYEDELEIT.G...IVDDPARH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.62|      52|     166|    2434|    2486|      11
---------------------------------------------------------------------------
 2434- 2486 (89.02/50.62)	PTILSACLVTLEPDAKLRVmPD.QFTPDERFSQISMQNPLSTPQDVTCT.HILVF
 2603- 2656 (83.59/43.31)	PHLEDVCPVFLKTALHLHV.PNiQIADDILNSTNAHQSANDHPLDSTLTaDVLRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.97|      20|      26|    1874|    1894|      18
---------------------------------------------------------------------------
 1874- 1894 (31.85/25.06)	NAIQ.PMLQSAFHcKSRGGAAG
 1902- 1922 (33.12/19.66)	NTVSgPLTWRQFH.RLAGRASG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25174 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAAAAEEDENKQTDSKQHVQQQIQQQQQQQQQQKQRQKLWN
2) ALSGAGSVHHGHGPNGGSSSSSCTPPSSNPHITGY
3) ASSGGSSSTPCQGGGASSTYSRNTQLGDPTVAAATAAAAASSSVGSPATPAPSPHPLSNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPTYAEHGNAAGGGGSQSLNAAPGSVPQQPATPTPATAGAAATTTATTTTSATAAGTGTAGAATGAGAGAGG
4) FVGSSRYAPLTNLPSQTQPPLQIPANCYYN
5) GDKTLLNPPDASASGSHSTKAPGAVPPSAAEHPHEPVIKLEPGTEPTPATQSSSNSSSGGAGGAGQEQDSKADVKAGG
6) GGAYGGASSADEADNALGGSGSGSGSGNMTATTTGNSFFQGLDIKTEPGLHSPCKESKSTSTAGSGSAGNNLFTAEG
7) IQSLCRKGNNNHNHNHNNKSVNEPVGKELEKLTTTTTTTSGQQQQQQQ
8) KSRAATLAKAAAAQQQQQQLQKHQQLQQRIQQHQQLQQQHQQQQLQLQQQQQQQHKHQQLHELLSAGPRTPMNAAMPSPSTTTTATTTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPIPSPGGPGVVPFPRSSPMHLGGMRQTPTHPPPPYPYELAAASP
9) NPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVSN
10) QAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTNNSSSTTT
11) RMDMNMLEFGHNNHHGQQHNPHQHSQHPHHPHQPHPAQHSQQLTAF
12) SNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVE
13) TSSYLNKQYNSQEPPGHPHTPQSVHHVMFGPM
466
1571
532
1152
2059
910
1658
1189
988
1059
1787
2539
1362
511
1605
733
1181
2136
986
1705
1358
1030
1106
1832
2570
1393










Molecular Recognition Features






MoRF SequenceStartStop




NANANA