<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25173

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLDDPILRSYSRCMQADMLCVWRRVQSTKQDNSDPNALNFEITTSTTVHPPLSLAAAKELWIFWYGEEPDLSELVDADLLKIAANQSLWNGTWKGELTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASGGGAAGARGQDANGTAQLPANSPLLDTATGNGTGEKSAATSTATPTQARKVMLAPFGIAAILTGNSYKASDPMAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEEMEFAELHGKVNGASSEPQTAAAAATGTGTGAGATQAAAAQALPMAASAAALAAAKESRKAATQAVSALERLTFQPYYDQRPTSGFTFNTNNTHIPPSAAIEMPERAWQDCIMNTLHVDAAAAAAAAAASADEEESKQTDSKQLVQQQIQQQQQKQRQKLWNFVDPMQKAPCICTKHLSNASGGGGGSSATPCHGGAAAGSASTYSRNSVGDSSSMPPIASSSVGSPATPAPSPHPLSNSAHSQPTSVPPAAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPTYADHGSQGGAPATLNAPGSVPQQQPATPTAGGASAGAAAGAGTATGAGTGAGAAAGAATAAPPSGAQCGTISVKKLEMQQQQPTIKQEPGTGRGSQQLPPQQQQQQQQQQSQKQQQQQPQQQQQQQSMATSTMEAVTNLFNLYKPPQLTLKDGDSVYDEEWLTEVYDFSYQESWDNLPVKRPKLNESVKLRRPRYAKNLYEGHTHFKPLMPSPGSVYGSLLTIEGGSVAALGAASESGKAAGGAGGGLVGIATNAGFGNAAGADEADNALVKSEAPSAAGDGSSFFPCLDIKTEPGLHSPCKETKSTSTAGSGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIDELKRSTAVTSAVVAAVVASSGAGSIQAEDLTKMFPTPPSHEQQHLNLSPCQTDVVMTDLSVDTTTTTTSSVLVVPAATITTAAATVAATATSVGLGVMLKMVKQEYSVELGSPVEEPIDDWSYVYRPPQQEKFVGSSRYAPLTNLPSQTLPPLQLPANCFYNPTWSHSQKSRAATLAKAAAAQQQQQQHQKHQQLQQRIQQHQQMQQQHQQQQQQQQQHQQQQQQQHKQLHDLLSAGPRTPMNAAMPSPSTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPIPSPGGPGVVPFPRSSPMQQHHPMRQTPTHPPPPYPYELAAASPATSTSSSYLNKPYGSQEPPGHPHTPHHVYGSMSGGAAGGAALMSGDSKLAMMQYTGGSAPESGTAAAAAAAVSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGSSFNPFPAQRGSSGAGGGGAGAVTPYNQYAGAGAGAGGLRMLSAFGGGLDSSPVAAALSGAGSVHGHGHGPNGGSSGSASCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDELEITGIVDDPARNKQPTLLALIQSLCRKGANNNNNNNNNNNNNSKDASSGKELEKLTNTTQQQLEQLAHAIFDLLLDQCSIIQSSSSSVHRALQAHRRRMSRQRRLGASVASIANVLEFTDAHDVVSLALEQARLAFENHRLDMNLLEFGHGHGQHGSQQNHPQHPNQPHHPHQQQQQSQQQLMAFQAAPALRQKLLSLGSSRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQSAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVICPDNDHVVASTRTYFRELSSTYEMCKLGRHTPIRGWDGILQVGVSERDVTTPLDDWLRTLDHAPLAEQIRRYAIAFMHQLAPYLSRVPGDKTLLNPPDPSGSHSTKAGVTQPPTAAEHPEQPVIKQEPGTEQQQQQQQQQQQSGATQTSNNQEQDSKADVKGGAAGGDTKPALVLGDPLGMGETLEDINPSAIVLYVVNPFTFASDSFELERLALIALLRCYAELLKVVPDSVRAQMNIQIISLESIMELGPCGNRRRFSDEIKCLALNIFSQCRRHLVHAQPVKSLTGFGTAANMEAFLKTKDEPNRRPYKMYTAPFVLAPMHERNDKTDFSRAAGSMHGQNETRYSVMYCNYCLSEDQSWLLATATDERGELLEKVCINIDVPNRARRRKAPARYVALRKLMDFVMGLISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCASFTRQFQNEPQVDDDFIFGEEEGNEDFSDADIGDLFWDSHMDRVSNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPNIQIADDILNSTNAHQSANDHPLDSTLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2687
PositionMiddle
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.447
Instability index52.47
Isoelectric point5.99
Molecular weight288873.31
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25173
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     195.39|      19|      19|    1233|    1251|       1
---------------------------------------------------------------------------
  764-  779 (28.11/ 9.88)	GTGRGSQ..QLPPQ........QQQQ
  780-  797 (38.93/16.64)	Q.QQQQSQKQQQQQP.......QQQQ
 1230- 1246 (28.87/10.35)	..QQHQKHQQLQQRI.......QQHQ
 1247- 1263 (37.48/15.73)	QMQQQHQQQQQQQ.........QQHQ
 1787- 1805 (31.59/12.05)	GHGQHGSQQNHPQHP.......NQPH
 2088- 2113 (30.41/11.32)	GTEQQQQQQQQQQQSgatqtsnNQEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.84|      16|      18|     592|     608|       2
---------------------------------------------------------------------------
  592-  608 (27.43/16.17)	PSPHPLSN.SAHSqPTSV
  610-  626 (23.41/ 8.71)	PAAEQLLNmSPHA.PTSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.35|      19|      20|     706|     724|       3
---------------------------------------------------------------------------
  718-  737 (33.41/11.99)	ATGAGTG.aGAAAGAATAAPP
 1523- 1541 (29.66/ 9.82)	SSGAGGG..GAGAVTPYNQYA
 1575- 1595 (26.27/ 7.87)	VHGHGHGpnGGSSGSASCTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.09|      17|      20|    1328|    1346|       4
---------------------------------------------------------------------------
 1314- 1332 (23.31/11.90)	PQAPPGSSMQQLMQRAgmS
 1333- 1349 (32.78/12.11)	PIPSPGGPGVVPFPRS..S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     124.67|      21|      22|     666|     686|       5
---------------------------------------------------------------------------
  372-  394 (27.99/ 9.94)	NGA.SS...EPQTAAaaATGTGTGAGA
  643-  663 (31.49/12.26)	NTP.AP...TPTDQH..DSKSITASPY
  666-  686 (40.08/17.95)	QTP.SV...EPPTYA..DHGSQGGAPA
  689-  713 (25.10/ 8.03)	NAPgSVpqqQPATPT..AGGASAGAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.72|      17|      19|     899|     916|       6
---------------------------------------------------------------------------
  555-  571 (29.28/10.44)	GGAAAGSASTYSRNSVG
  900-  916 (30.44/12.86)	GSVAALGAASESGKAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.46|       9|      19|    1182|    1191|      10
---------------------------------------------------------------------------
 1182- 1191 (14.21/ 8.90)	YAPlTNLPSQ
 1204- 1212 (20.25/ 9.00)	YNP.TWSHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.15|      13|     485|     539|     551|      11
---------------------------------------------------------------------------
  539-  551 (25.53/12.88)	SNASGGGGGSSAT
  982-  993 (22.51/10.22)	STA.GSGGGNLFT
 1027- 1039 (24.11/11.64)	SNNPSNGGCSAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.72|      15|      23|    1600|    1615|      13
---------------------------------------------------------------------------
 1600- 1615 (25.32/27.91)	HITGYVDDDPVECTcG
 1626- 1640 (27.40/21.58)	HRAGLFYEDELEIT.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.96|      21|     543|     923|     961|      16
---------------------------------------------------------------------------
  932-  961 (29.38/36.07)	GNAAGADEAdnalVKSEAPsaagdGSSF..FP
 1496- 1518 (38.58/12.11)	GNIRGADSG....VYVPLP.....GSSFnpFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.12|      37|     543|    1264|    1302|      17
---------------------------------------------------------------------------
 1264- 1301 (64.92/31.67)	QQQQQQHKQLHDLlSAGP..RTPMNAAMPSPSTVPQ.P.LSS
 1809- 1849 (52.20/20.85)	QQQQQSQQQLMAF.QAAPalRQKLLSLGSSRLTVHKwPyLPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.36|      44|     213|    1907|    1953|      18
---------------------------------------------------------------------------
 1907- 1953 (76.17/56.31)	GRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYwdkFLLEPYSYARD
 2122- 2165 (75.18/46.40)	GAAGGDTKPALVLGDPLGMGETLEDINPSAIVL...YVVNPFTFASD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.56|      45|     735|     295|     356|      23
---------------------------------------------------------------------------
  295-  356 (62.19/76.55)	AAILTgnSYKASDPMAekilEDWASFFPlcnkdntdVPPVVEvvsGGHKMYHPTNY.VLVTDL
 1057- 1102 (77.37/48.10)	AAVVA..SSGAGSIQA....EDLTKMFP........TPPSHE...QQHLNLSPCQTdVVMTDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25173 with Med13 domain of Kingdom Metazoa
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