<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25169

Description "Uncharacterized protein, isoform B"
SequenceMNQNQIQQLTSHLSQALDQNYDVVNMEAVLSVICALEGTTITKEQLEATRLAKYINQLRRRTKNDQLARRAKSLLKKWREMVGINQQTSIDSQSKHMDQSTFKPMVETNLTGSESNATEADLNQIQYNSQPFSPTLQRVISNLHTNIDSSEPKLHHQTNFSSLINNNINIDNRDNRDESLTIVNKQIQYKPQNSSTITNEHSSNSVSSAFVANDNFNQASIVIDIVSDSDENDTVNSQKKLETESSLLATPSHYFRPKKLKKDKKYKDRDSRDKPLFNLKGETSQQSKNSKKSKTPKVYSTDPEILSLSNSSMSSLLSGDAVSGNFQTRLHPPAADLTFAGRFKSVGRLETFSNVITVQANGQKSTTSVIDTSIEVPTRPIYEDNNDSNTSCSRLSPYDELEPKLDQNRLKSCEETIPKKRGRKKGSKGVDSLIAKESSLSQQIFFGSGVKKVKTTKELFNEIQSRKLSTSFNRGENTTAPSVTNRILSTSSTNVRNLECRSLHTRPASSCSETSIHSPHALEPFSSNVSLAGTEKHSNTLEDPGNTDSDTVTSELSRDSKPRNKRIHSLDSNSNSHQQTSSAKSAEDVVMKTDYNDVRTQLMHIVRSLNSPLTVDETEKRYQAEIVPCTCIIFEDMPKESFEHNKLSQIGKESDLVNKGSSDIDISRDKRHNEQTAIKTENCVVDAAEQTIAQKPMKSIFDLDFDDDDDPLHTIIKHVSPTESNVKTKLDIDFDSTDSNVVSLAEEDINKDSKAEITDSFPADQESSNIIAEPISIYTVREDPKCIAKQRFDIQTNDVTNFHINALHNYYIPNINGNWNSIDSSLVLKSSSITEFLQTLESYTVTDGSDVVPKYGSLTYEQRIRKDLSYLKFVQNYKSKSFKSFMPPFLGVAKCLPTCRLAAKRLKDKTKSLPTINSANMLVKQEKSEMHCSYFANNSSGPNPLRVEVTINDTQKNNESQVRYSDDNPIKHNAELSYNLLKVVNSENHENFKKSDDSNAGYTNMKYRRYRRNSTCSSSNLQLTQDSINEKLRNQRAEYTEISEQSESNIERNRKKRRKRNNSTPYDKHNIKNLTIEEKPRIKRIKIAINGNVSTHRQISVISSGDISCGDEEEAHIEMSDMEVGFDNIGYSHYAPGASDDDHESNRSHSTTVDSILADDDHMENDDDNNSDDEEYAIVQRPLAHGGGSNNHIVLTIKKTPSKINSPANSISAISPIVGVATEVEMSTGKQQDAEIVTSNLSVESKCEAHGSESILCQTLLQ
Length1262
PositionUnknown
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.05
Grand average of hydropathy-0.822
Instability index49.22
Isoelectric point6.07
Molecular weight141451.84
Publications
PubMed=17994087
PubMed=18057021

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25169
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.90|      25|      26|    1008|    1033|       1
---------------------------------------------------------------------------
 1008- 1033 (39.94/27.74)	RRYRRNSTCSSSNlQLTQDSINEKLR
 1057- 1081 (42.96/25.72)	RRKRNNSTPYDKH.NIKNLTIEEKPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.71|      25|      27|     943|     967|       2
---------------------------------------------------------------------------
  915-  946 (21.63/10.32)	...TIN...SAnmlvkQEKSEMHCSYfannsSGPNPLR
  947-  971 (42.83/30.04)	VEVTIN...DT.....QKNNESQVRY.....SDDNPIK
  974-  997 (21.25/ 9.97)	AELSYNllkVV.....NSENHENFKK.....SDD....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.09|      14|      18|     510|     524|       4
---------------------------------------------------------------------------
  510-  523 (26.17/10.59)	SCSETSIHSPHALE
  574-  587 (19.91/ 6.14)	SNSHQQTSSAKSAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.94|      17|      18|     466|     482|       6
---------------------------------------------------------------------------
  466-  482 (29.71/19.73)	RKLSTSFNRGENTTAPS
  486-  502 (29.24/19.28)	RILSTSSTNVRNLECRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.32|      54|      56|      87|     142|       7
---------------------------------------------------------------------------
   87-  142 (86.37/51.21)	QTSIDS.QSKHMDQSTFKPMVETNLTGSESNATEADLNQIqyNSQ.PFSPTLQRVISN
  144-  199 (83.96/44.10)	HTNIDSsEPKLHHQTNFSSLINNNINIDNRDNRDESLTIV..NKQiQYKPQNSSTITN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.87|      63|     158|     230|     297|       8
---------------------------------------------------------------------------
  230-  297 (98.22/75.46)	DENDTVNSQKKL....ETESSL....LATPSHYFrPKKLKKDKKYKDRDSrdkpLFNLKGETSQQ...SKNSKKSKTPK
  384-  457 (90.65/55.93)	DNNDSNTSCSRLspydELEPKLdqnrLKSCEETI.PKKRGRKKGSKGVDS....LIAKESSLSQQiffGSGVKKVKTTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.09|      30|      49|     619|     650|      10
---------------------------------------------------------------------------
  619-  650 (48.21/39.17)	EKRY..QAEIVPCTCIIfeDMPKESFEHNKLSQI
  669-  700 (44.88/29.27)	DKRHneQTAIKTENCVV..DAAEQTIAQKPMKSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25169 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ENHENFKKSDDSNAGYTNMKYRRYRRNSTCSSSNLQLTQDSINEKLRNQRAEYTEISEQSESNIERNRKKRRKRNNSTPYDKHNIKNLTIE
2) KKLKKDKKYKDRDSRDKPLFNLKGETSQQSKNSKKSKTPKVYSTDPEI
3) NIGYSHYAPGASDDDHESNRSHSTTVDSILADDDHMENDDDNNSDDEEYAIVQRPL
4) PKLDQNRLKSCEETIPKKRGRKKGSKGVDSL
5) QQTSIDSQSKHMDQSTFKPMVETNLTGSESNATEADLNQIQYN
6) RVISNLHTNIDSSEPKLHHQTNFSSLINNNINIDNRDNRDESLTIVNKQIQYKPQNSSTITNEHSSNSVSSAF
7) TNVRNLECRSLHTRPASSCSETSIHSPHALEPFSSNVSLAGTEKHSNTLEDPGNTDSDTVTSELSRDSKPRNKRIHSLDSNSNSHQQTSSAKSAEDVVMKTD
8) TTSVIDTSIEVPTRPIYEDNNDSNTSCSRLSPYDEL
987
258
1128
403
86
138
493
366
1077
305
1183
433
128
210
594
401










Molecular Recognition Features






MoRF SequenceStartStop




1) EEYAIVQRPL
2) LHTIIK
3) SHYFRPKKLKKDKKYK
1174
712
252
1183
717
267