<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25168

Description Uncharacterized protein
SequenceMCDAVATTTPATPTIPAAAGSGPGVAAGDTTTSTAMEERTRQSCCRLCIAPASECISIINSYAADKEPLATKIHNCVNIKITPLDRLSLHICHACISYLNSWQSFKNRCLSSQSKQRQWLDSDKSKQQTLLGYLDLNKTENGSSIEQQQQQQQQQLESNIDSATIAAEKASANILDGIPSLKKRKSLTVYYQQHQQRVKQPHYHQQHPQQAQHHQRLSRIRQPRRQQQATMSGQRLVKFKPKLFMPLDIAVPPLPPLLPTPSQQQPTDTVAAGAKLAPLPLPLPLPLDFSQNPNQNPNTNASQSQQKHGSVLPLPVPVPVTVPVSLPPSTPQLPQLPPLPAATMTSNAAAPSAVSAAVTTPLLMPVTLQSAAQQLRFFRRYSYNVIVSCIRKRVHKSHTQPTPSTSPDASASAYFLFDKLQRILYIYLFLYTYMYKYIYPLPAVPIKDEPIDDTDDDFQMKCIDESDDMMDPTMFLERSEHEGDVPLMTSDYDYTAQHGVTAVAAAASLPASAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPNNTPITKPTPALAAALEIQRAAAAAAATAEATKAAAGGNISAQKYRQVVMNTFIKCENGGFDYDNPEQYQHLLTRDKVDFIQENNEFLEQYQTMTCRCCNKYFNTYKNFMAHVRKKYPLLPRNLCFNCLKMNDSKALFISHLKKRNCINLYRVLNALRLKQPNFSHANASGVAVSAADLSVGQAAAAAAASAGHETSSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCTFCGLDFADPVDRRRHYNNMECIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVSSDNASTANSGGMDHSPGKRSLLGALGIGISQSSNDESRSSTHNNNNAAEAAFTSTPKPSGGAAGGTGGTAAAVSGGGSTSGSRDAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSMPNVYTGRYDYVMKDLMSITNGGTLDEDEEESGSVAKKMRLDDSSNNSSINMSIANQQKECLICNAVFSNNIGLSNHMRSHYTAATATNAALAAANRMTPKSLTITATPPLDTTAATSTSAAAGAGGGGTAATSAAGAGSGAGGGSTTASGLPPAMVHQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGRAIKDEMIVKQFECDICSIVYSSELELQQHKRSVHKSHDAASKSSATKSSTATSAAELADTSGTGGGGAGAGAALPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPDPVECTLCRKMFFDRQMLENHTPTCNRKPITATGAHQQDQQQHQQQQQQLQQQRAIFKHKTGDDDDEEEDDQLMLVDDGGVGSDSNGAAATSGTSSNNPNAISASTMKIRIPEVACTICGARFTDQEMFTKHIQKHEQDLYVDNPLAAMFDDGPADVGQFKVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNLIIDGEATTLNNSSSNNNNNNNSLSSSSMLRELHAVGLMPNQQQHQKQQQQQQQQQQQQQQRNNTSSSSSKSLKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIEVDEPLTCRRCGDIRFDTKEQWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLINHINNHLKEDVIVPVATAASKAPVLPNKAKTAAGTAAATATTTAAKGIVRAAAGAGGRVNKGKQLEEQLTMKVATKQQQQQQQEEQQQQQASNDDHAEEDDDDEGDVDDEDDDDEEDVDGDVVEQQLLQQKQQQQQQQQQQQQQQQQQQQQLAANANANANANSKQQQQQQPRRLNFDYSRSDSAKLNGNGKQTPQQLAAAKSKAGQSAVLVMHSSEEDEEDDDEEGVEGEAMNIDDIIEEDDDGVADADADVDGDVDGDDDGDVDGDATSSSGSESTATSHSIGERRKKSVVKSAAHGAAADQSNSSYTCDLCQLCFDSQEQLQSHIKSHFLNGPSAGGSGSNSSNSRRIGAGAGSSSNSITD
Length2152
PositionKinase
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.686
Instability index54.51
Isoelectric point6.72
Molecular weight236115.18
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:InterPro

GO - Biological Function
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25168
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     976.69|     238|     259|     868|    1122|       1
---------------------------------------------------------------------------
  742-  916 (199.38/122.59)	.............GQAAAAAAASAGHETSSERPEklrAKE.....................LLVNKLYE.CKLCPKGFRTKHEFRTHVYD..KHADvqrKD.........NNSIQCTFCGLDFADP..VDRRRHYNN............................MECIV..RLR...................................................................................................................CMTCDAKLETHQRFLDHVyQDHlggvssdNASTANSGGMDHSPGKRslLGALGIGISQSSNDesrsstHNNNNAA..EAA
  917- 1156 (334.32/209.33)	FTSTPKPSGGAAGGTGGTAAAVSGGGSTSGSRDA...PKS.....................QYFSRMPQvCPICGQQYNNYNNVLRHMES..KHPN...KL.........PETYKCVRCGLGYPRI..SYLREHMINVHGVDKNRHSggfeyIVNADAVKlADGSMPNVYtgRYDYVMKDLMSITNGGTLDEDEEESGSVAKKMRLD...DSSNNSSINMSIANQ...........................QKE...................................CLICNAVFSNNIGLSNHM.RSHytaatatNAALAAANRM..TP......KSLTITATPPLDT................TA
 1157- 1324 (197.74/107.31)	ATSTSAAAGAGGGGTAATSAAGAGSGAGGGSTTAsglPPAmvhqtpqeqavfrrsldqaadRRFRRMR..CRICQRRFSSKKSYRYHMLT..DHQV...QN.........VQFIKCKLCNAEFAYE..KGLKVHLFKVHG.......................RAIK.........................DE....MIVK..................................................QFE...................................CDICSIVYSSELELQQHK.RS..............................................vHKSHDAAskSSA
 1325- 1397 (53.23/18.89)	TKSSTATSAAELADTSGT....GGGGAGAGA.AL...PLY.....................WY.....Q.CKYCPSNFNTNKKLAIHINS...HDE...FD.........SNDYSCKDCGNVY.......................................................................................................................................................................................................................................................
 1415- 1517 (108.92/53.16)	..............................................................................................................PDPVECTLC.......rkMFFDRQMLENHTPTCNRKP.....ITATGAHQ.QDQQQHQ....QQQQQLQQQRAIFKHKTGDDDDEEEDD..QLMLVD...DGGVGSDSNGAAATS...........................GTS...................................SNNPNAI.........................................................................
 1697- 1808 (42.70/14.36)	......................................................................CEYCASTFISNNNLRRHMYElhKHEV...SNlpeppvievDEPLTCRRCG.........................................................................................................dirfdtkeqwiehkladakvvrpfcpfQWG...................................CDLCGEYLSRKEKLINHI.NNHlkedvivPVATAAS............................................
 2024- 2149 (40.40/11.61)	..........................................................................................................................................................................................DDIIEEDDDGVADADAD..VDgdvDGDDDGDVDGDATSS...........................SGSestatshsigerrkksvvksaahgaaadqsnssytCDLCQLCFDSQEQLQSHI.KSH...flngPS..AGGSGSNSSNSRR..IGA.GAGSSSNS....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     180.41|      24|     259|    1654|    1677|       2
---------------------------------------------------------------------------
  130-  155 (30.33/10.40)	LLGylDLNKTENGSSIEQQQQQQQQQ
 1654- 1677 (51.33/22.24)	LMP..NQQQHQKQQQQQQQQQQQQQQ
 1864- 1878 (22.70/ 6.09)	...........KQQQQQQQEEQQQQQ
 1916- 1939 (48.81/20.82)	LQQ..KQQQQQQQQQQQQQQQQQQQQ
 1940- 1962 (27.23/ 8.65)	LAA..NANANANANSKQQQQQQPRR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.72|      15|      21|     192|     206|       3
---------------------------------------------------------------------------
  192-  206 (31.18/18.29)	QQHQQ..RVKQPHYHQQ
  212-  228 (25.54/13.50)	QHHQRlsRIRQPRRQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.77|      21|      21|     496|     516|       4
---------------------------------------------------------------------------
  496-  516 (35.07/21.00)	AQHGVTAVAA..AASLPASAVAN
  518-  540 (31.70/18.22)	AAAGDSKVAScrACSLQFSTRAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.02|      16|      21|     312|     327|       5
---------------------------------------------------------------------------
  279-  297 (25.87/12.25)	LPLPLPL.........PLDFsqnPNQNP
  312-  327 (30.28/15.56)	LPLPVPV.........PVTV...PVSLP
  336-  359 (17.87/ 6.24)	LP.PLPAatmtsnaaaPSAV...SAAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.73|      12|      20|    1881|    1892|       6
---------------------------------------------------------------------------
 1881- 1892 (21.85/11.86)	NDDHAEEDDDDE
 1898- 1909 (23.85/13.66)	EDDDDEEDVDGD
 2008- 2019 (22.03/12.02)	EEDDDEEGVEGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.09|      20|      20|     685|     704|       8
---------------------------------------------------------------------------
  656-  675 (40.14/23.65)	CRCCNKYFNTYKNFMAHVRK
  685-  704 (36.96/21.21)	CFNCLKMNDSKALFISHLKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.42|      20|      21|      54|      74|       9
---------------------------------------------------------------------------
   54-   71 (25.75/12.40)	..ECISIINSYAADKEPLAT
   73-   91 (31.11/18.10)	IHNCVN.IKITPLDRLSLHI
   92-  106 (23.57/ 7.61)	CHACISYLNSWQSFK.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.19|      11|      56|    1528|    1538|      10
---------------------------------------------------------------------------
 1528- 1538 (21.91/12.48)	EVACTICGARF
 1585- 1595 (22.27/12.81)	EYACDLCAKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.83|      10|      23|    1571|    1580|      13
---------------------------------------------------------------------------
 1571- 1580 (17.46/ 9.42)	DVGQFKVERQ
 1597- 1606 (16.37/ 8.42)	QVIALKVHRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25168 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGGSTTASGLPPAMVHQTPQEQAVFRRSLD
2) APVLPNKAKTAAGTAAATATTTAAKGIVRAAAGAGGRVNKGKQLEEQLTMKVATKQQQQQQQEEQQQQQASNDDHAEEDDDDEGDVDDEDDDDEEDVDGDVVEQQLLQQKQQQQQQQQQQQQQQQQQQQQLAANANANANANSKQQQQQQPRRLNFDYSRSDSAKLNGNGKQTPQQLAAAKSKAGQSAVLVMHSSEEDEEDDDEEGVEGEAMNIDDIIEEDDDGVADADADVDGDVDGDDDGDVDGDATSSSGSESTATSHSIGERRKKSVVKSAAHGAAA
3) GVSSDNASTANSGGMDHSPGKRSLLGALGIGISQSSNDESRSSTHNNNNAAEAAFTSTPKPSGGAAGGTGGTAAAVSGGGSTSGSRDAPKSQ
4) IIDGEATTLNNSSSNNNNNNNSLSSSSMLRELHAVGLMPNQQQHQKQQQQQQQQQQQQQQRNNTSSSSSKS
5) KSLTITATPPLDTTAATSTSAAAGAGGGGT
6) LPLPLPLDFSQNPNQNPNTNASQSQQKHGSVLPL
7) PTCNRKPITATGAHQQDQQQHQQQQQQLQQQRAIFKHKTGDDDDEEEDDQLMLVDDGGVGSDSNGAAATSGTSSNNPNAISAST
8) QSHIKSHFLNGPSAGGSGSNSSNSRRIGAGAGSSSNSITD
9) VYYQQHQQRVKQPHYHQQHPQQAQHHQRLSRIRQPRRQQQATMSGQRLV
1183
1810
863
1618
1142
281
1438
2113
189
1213
2090
954
1688
1171
314
1521
2152
237










Molecular Recognition Features






MoRF SequenceStartStop




NANANA