<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25166

Description "Uncharacterized protein, isoform A"
SequenceMMADHLDEPPQKRVKMDQTDLYFLEDNLPDELVSSSSGWSDQLNTGGGGGGGVGGVVSTASGVVGAGGPNKPPTQGPGPGVVPPQMNGAGGGGDDGSGNGGSGAAGSQLRQLQHHQHLQQLLQHQQQGNKGAGGGMVVPGMNQLGSKSPNLQSPNTAGMQVATQMGMVNSMPMSISNNGNNGMNSIPGMNSIAQGNLGNMVLTNSGGMGTIGGAGLVNTLKQPGGASMMSTVPGSVGVSSVTGAAPSQGMHMQNGPMMGRMVGGQQHLLRGPHLMGGGAGGGNGPGGVVGAGGGPRMQNPNMQLGQINNMPYGVGNYGAPGSNNTQLLAQQMAQRGAGGVGGVVAPNMSAGMAQANRPIGTVVPMSNLGGDGAPPGAGGLVGNTQQQQQQLAAANAQMNSQQQQQQQPPGVQQGAMGPRAPQPNQLLGHSQQQQQQQQPGTSQQQQAIASGVASSVSVAAPAPASSNMTDERKKQIQQQLMLLLHAHKCNKRENMNPNREVCSVNYCKAMKAVLAHMATCKQSKDCPMQHCTSSRQILLHYKTCQRSDCIICSPFRQNNSLFQNASGGGGGGGAAVAPNASPLQQQQQQQQQQQQQQLPQGQQQVPQNPSGVGVGVGGGVGVGVGVGVDTKQVAQSAGTCGAPNTAIVLPQQQAAGASNVPKGNTDMGQQQQQQQHQQVQQQELRRFEGVGSIGQVGPVPAGMLGAPGQGMAPGIRMQGAPSVRVLGVQPGQPGSTMASGGVPVPVPVPGQNVLPGANDVGSLQQQQQQAAQAAQQSGQLMLQGCNTGTGGRRRALQNMVDQQQQPNAQQQSVQQQQQQQLGNIPAPLSVNVGFNNANFVGVGDKQQQQQQQQQQQQQLVGQSDQMTKLKLQAQAQAQVQAHVNVVSAGGAPGSGNSASGGASVLMPADTTGGANSASAGSNAVGTGAGGAAGGGAPGNGSDSEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVTYAEKVEKDMYEMAKNRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQQLLQMQQGGPNSSVVNPTSVPNNALQQQQQPGQGVRPNISPMGGGGGGGGGPSGMMQQQMRPQAPGMGVGVGVGQQQQTAAGQANMVAVAASMRSHSPGGNMLAIQQQQRMQFPQQQQPGQGNMLVGPPGPSPGGMVANPVLSPFNTQQTMQSATAVGGGPGILTSPVPGQQQQQQQQQQQQQQQFINANGSSGAQNSQISEIMKQRLLQHQQQTNAAAMLLPQSPFNNATPIQQPQQQQQQQQQQQQQQQQQQQQQQQQQQTNAFSSPMQQKTQPPGSVLNNMPPTPTSLDALNAGAASAGAGSIGGGTVAAPSPSPSFMSNGPIGTPSNNPPSVSSLMQPLSNRAATPPYIPTSPVPATSASGLTASSTPASAAATCSSSGSGSSTSSSAVVTTTTVTTPLSCASSSGTTPTSTTTSTSGNGSATPASSTLLQMARSNSENSAPGRVMSSSSSLSSQMAALEAAARDNDDETPSPAGANDTNGSNGGSGGGMASKGKLDSIKQEDDIKKKFMDDSCGGNGDSSQMDCSTGGKGKNVNNDGTSMLKMEIKTEVGADVKPIKSDPMDVDESAVSSGIAGGANGDGTIGGSGVDSKDDINGAIDGVSSGLAADIKLKSETKPHVPEPLAPNAGDKKKKCQFNPEELRTALMPTLEKLYRQEPESVPFRYPVDPQALAIPDYFEIVKKPMDLGTIRSNILNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTFCQKCFNDIQGDTVTLGEDPQQSQTQIKKDQFKEMKNDHLELEPFVDCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEASAGEVHIRVVSSSDKCVEVKPGMRRRFVEGGEMMQEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEDNEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSAKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHYEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNNCKTAVETRYHCTVCDDFDLCTVCKEKVGHPHKMEKLGFDLDDGSAPADLKQANPQEARKQSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVQHTKNCKRKTNGGCPICKQLIALCCYHAKHCQEQKCPVPFCPNIKHKLKQQQLQQKLQQQQLLRRRVALMSRTAAPAALPGPAVSGPVVASGAVGVGGPVVGMSGVAVSQQVMSGQAAIMPAGGGGMSPSTVAVPSPVSGAVMAGMTSPHPHQPGIGMKPGGHSPSPNVLQVVKQVQEEAARQQVPHGGSFGKGVPMAPPVMQRPMGVGVSNQGGMGGMVSNVGGNQLAGNVGVVPGGGQLPSGANCNNILNANNLLPLDQWGGSGGPGQQRYTNNAPNQPGMRQPNQLMQQNIQQQQQQMMGMPPNQLGVGVGVGVGAGQMPVVGSGVNMGGGGAPHSIGLGSQIGAAASGGGVRPPGAQGVGGGGAGGAGPNMGNGPPLNTQTLAHIMQKIKNNPTNESNQHILNILKQNPQIMAAIIKQRQQSQINAAAGGAGGPPGAIQAGNGPQTPQQQQQQQQVMQQQQMQHMMNQQQQGPGPGPQQMGPGQQQQVSLMQAAQQQQQGPPHQRMANMQNTAMMLPNLPPGSQGGMVPNQNLNKMRYMPMNQYPPPYPQRQRGPHMGVFGQPPFPGGTAGNFNAGGGGNVSGIPVAGAAVGSGASGPGSDQYSMANAAASNMLQQQQGGGGAGVKPGPQQQQQQQQQQMGVMPPGMQQQQPMQQQQQQQQMMQVVAAGGGGMSSTNPQNTLPGGGGGPSGPGANVMGPPTPHTLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRGPSASPRAQPSPHHVMSSHSPAPQGPHDGLHNHGMHHQSPLPGVPQDVGVSGVGVGVGVGVGVNAGNVGNAGGSLPDASDQLSKFVERL
Length3233
PositionTail
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.04
Grand average of hydropathy-0.612
Instability index59.05
Isoelectric point8.98
Molecular weight339313.22
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:EnsemblMetazoa
histone methyltransferase complex	GO:0035097	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa
presynapse	GO:0098793	IEA:GOC

GO - Biological Function
histone acetyltransferase activity (H3-K18 specific)	GO:0043993	IEA:EnsemblMetazoa
histone acetyltransferase activity (H3-K27 specific)	GO:0044017	IEA:EnsemblMetazoa
histone methyltransferase binding	GO:1990226	IEA:EnsemblMetazoa
RNA polymerase II transcription factor binding	GO:0001085	IEA:EnsemblMetazoa
transcription coactivator activity	GO:0003713	IEA:EnsemblMetazoa
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
circadian regulation of gene expression	GO:0032922	IEA:EnsemblMetazoa
DNA replication checkpoint	GO:0000076	IEA:EnsemblMetazoa
glial cell migration	GO:0008347	IEA:EnsemblMetazoa
histone H3-K4 methylation	GO:0051568	IEA:EnsemblMetazoa
histone H4-K12 acetylation	GO:0043983	IEA:EnsemblMetazoa
histone H4-K8 acetylation	GO:0043982	IEA:EnsemblMetazoa
locomotor rhythm	GO:0045475	IEA:EnsemblMetazoa
negative regulation of canonical Wnt signaling pathway	GO:0090090	IEA:EnsemblMetazoa
neurotransmitter secretion	GO:0007269	IEA:EnsemblMetazoa
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
positive regulation of smoothened signaling pathway	GO:0045880	IEA:EnsemblMetazoa
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa
R3/R4 cell fate commitment	GO:0007464	IEA:EnsemblMetazoa
R7 cell differentiation	GO:0045466	IEA:EnsemblMetazoa
regulation of mitotic nuclear division	GO:0007088	IEA:EnsemblMetazoa
synapse assembly	GO:0007416	IEA:EnsemblMetazoa
thermosensory behavior	GO:0040040	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25166
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|     969.35|      64|      64|    1200|    1263|       1
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  252-  298 (55.29/ 8.92)	..........................................MQ......................NGP...MM......GR......M...........VG....G............Q.QHLLRGP.........H.......LMGGG...AG..............G....GN...G...PGGVVG........A.GGG..........P.......RM.............Q
  299-  385 (52.12/ 7.82)	NP..NM..QLGQinnmpygvgnygapgsnntqllaQQ.....MAQ..................R..GAG...GV......GG......V...........VA....P............N.MSAGMAQ.........AnrpigtvVPMSN...LG..............GD...GA.........PPG...........AGG..........L.......V......GN.....TQ
  587-  671 (73.02/15.06)	QQ..QQ..QQQQ.......................QQqlpqgQQQ..................V..PQN...PSgvgvgvGG......G...........VG....V............G.VGVGVDT.........K.......QVAQS...AG..............TC...GApntA...IVLPQQ........Q.AAG..........AsnvpkgnTD....MGQ.....QQ
  672-  725 (59.08/10.23)	QQ..QQ..HQQV.......................QQ.....QEL................rrF..EGV...GS......IG.....................................Q.VGPV.PA.........G.......MLGAP...GQ..............GM...AP...G...IRMQGA........P.SVR..........V.......................
  766-  846 (49.00/ 6.74)	QQ..QQaaQAAQ.......................QS.....GQL..................MlqGCN...TG......TG......G......rrralQNmvdqQ............Q.QPNAQQQ.........S.......VQQQQ...QQ............qlGN...IP...A...PLSVNV........G.FNN..........A.......NF..vgVGD.....KQ
  847-  898 (51.69/ 7.67)	QQ..QQ..QQQQ.......................QQ.....QQL..........................vG...........................QS....D............Q.MTKLKLQ.........A.......QAQAQ...VQ..............AHvnvVS...A...GGAPGS........G..NS..........A.......................
 1060- 1140 (67.63/13.19)	QQ..QQ..PGQG.......................VR.....PNI..................S..PMG...GG......GG......G............G....G............G..PSGMMQ.........Q.......QMRPQ...AP..............GM...GV...G..vGVGQQQ........QtAAG..qanmvavaA.......SMrshsPGGnmlaiQQ
 1141- 1206 (67.74/13.24)	QQrmQF..PQQQ.......................QP.....GQ.......................GNmlvGP......PG......P...........SP....G............G.M..VANP.................VL.SPfntQQ..............TM...QS...AtavGGGPG............................iltsPV....PGQ.....QQ
 1207- 1273 (86.50/19.73)	QQ..QQ..QQQQ.......................QQ.....QQF..................I..NAN...GS......SG......A...........QN....S............Q.ISEIMKQ.........R.......LLQHQ...QQ..............TN...AA...A...MLLPQS........P.FNN..........A......tPI..qqPQQ.....QQ
 2455- 2576 (48.35/ 6.52)	QQ..QL..QQKL.......................QQ.....QQLlrrrvalmsrtaapaalpG..PAV...SG......PVvasgavG...........VG....GpvvgmsgvavsqQ.VMSGQAA.........I.......MPAGG...GGmspstvavpspvsgAV...MA...G...MTSPHPhqpgigmkP.GGH..........S.......PS....PNV.....LQ
 2696- 2746 (68.12/13.37)	QQ..NI..QQQQ.......................QQ.....MMG..................M..PPN...QL......GV......G...........VG....V............G.VGAGQMP.........V.......V...G...SG..............VN...MG...G...GGAPHS........I.G....................................
 2861- 2895 (68.35/13.44)	QQ..QQ..VMQQ.......................QQ.....MQH..................M.................M......N...........Q........................QQQ...................................................G...P.GPGP........Q.QMG........................PGQ.....QQ
 2896- 2961 (63.65/11.82)	QV..SL..MQAA.......................QQ.....QQ......................QGP...PH......QR......M...........AN....M............Q.NTAMMLP.........N.......LPPGS...QG..............GM...V...........PNQ........N.LNKmrympmnqypP.......PY....P.Q.....RQ
 2971- 3042 (63.07/11.62)	QP..PF..PGGT.......................AG.............................NFN...AG......GG......GnvsgipvagaaVG....S............GaSGPGSDQysmanaaasN.......MLQQQ...QG..............G....GG...A...GVKPG......................................PQQ.....QQ
 3059- 3115 (95.74/22.94)	QQ..PM..QQQQ.......................QQ.....QQM..................M..QVV...AA......GG......G..............................G.MSSTNPQ.........N.......TL..P...GG..............G.....G...G...PSGPGA........N.VMG..........P.......PT....PHT.....LQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.03|      63|      72|    1319|    1389|       2
---------------------------------------------------------------------------
 1337- 1410 (89.10/47.88)	GSiGGGTvaapSpSPSFMSNGPIGTPSNNPPSvsSLMQPL.S.......NRAATPPYIPT.S..............P.........VPaTSASGLTASS......tpASAAA
 1416- 1513 (64.23/21.72)	GS.GSST....S.SSAVVTTTTVTTPLSCASS..SGTTPT.StttstsgNGSATP...AS.StllqmarsnsensaPgrvmsssssLS.SQMAALEAAArdnddetpSPAGA
 3124- 3168 (54.70/16.21)	..................SSPPIRSP...........QPTpS.......PRSAPSPRGPSaS..............P........rAQ.PSPHHVMSSH........SPAPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     256.36|      40|      66|    2750|    2789|       3
---------------------------------------------------------------------------
  111-  154 (50.81/14.17)	QLQHHQHLQQLLQHQQQGNKGAGGGmvvPGMN.QLGSKS..P......nLQSP
  397-  434 (52.43/14.99)	QMNSQQQQQQ.QPPGV...QQGAMG...PRAP.Q.......PnqllghsQQQQ
 2580- 2608 (38.04/ 7.79)	QVQEEAARQQV.PH......GGSFG...KGVP.MA...P..P......vMQ..
 2750- 2789 (72.58/25.06)	QIGAAASGGGVRPPGAQGVGGGGAG...GAGP.NMGNGP..P.......LNTQ
 2832- 2860 (42.49/10.01)	QINAAAGGAG.GPPGA................iQAGNGPqtP.......QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     151.00|      46|      66|    1548|    1597|       4
---------------------------------------------------------------------------
  901-  930 (29.14/ 6.97)	...........................G.ASVL.MPADTTGGANSASAGSNavG.T....G...AGG
  931-  959 (35.58/11.38)	AAGGG.....APGNG....SDSEK..DW.RESVTADLRNHL..........................
 1554- 1613 (52.52/28.81)	NGDSSqmdcSTGGKG....KNVNN..DG.TSMLKMEIKTEVGADVKPIKSDpmDvDesavSsgiAGG
 1615- 1654 (33.77/10.39)	NGDG.....TIGGSGvdskDDINGaiDGvSSGLAADIK..LKSETKP....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.10|      27|      83|    2311|    2338|       5
---------------------------------------------------------------------------
  526-  552 (38.51/20.24)	CpmQHCTSSRQILLHYKTC..QRSD.CIIC.
 2311- 2337 (50.33/30.20)	C..NNCKTAVETRYHCTVC..DDFDLCTVCK
 2398- 2423 (41.27/22.57)	C..QKMKRVVQ...HTKNCkrKTNGGCPICK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.13|      13|      70|    1755|    1768|       7
---------------------------------------------------------------------------
 1732- 1744 (23.91/11.18)	NGKYSDPWEYVDD
 1756- 1768 (23.21/17.39)	NRKTSRVYRYCTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.10|      11|     214|      98|     108|      10
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   98-  108 (21.39/ 8.82)	GNGGSGAAGSQ
  313-  323 (22.71/ 9.99)	GVGNYGAPGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.81|      14|    1766|    1290|    1304|      11
---------------------------------------------------------------------------
 1291- 1304 (28.64/ 7.79)	QQQQQTNAFSSPMQ
 3044- 3057 (30.18/14.12)	QQQQQMGVMPPGMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.69|      53|      62|    2050|    2102|      12
---------------------------------------------------------------------------
 1980- 2029 (65.46/38.89)	...GEM..MQE.FPYRAKALFAFEEVDGIDVCFfgmHVQEYGSECPAPNT.RRVYIA
 2050- 2102 (98.54/62.65)	ILLGYMDYVKQ.LGYTMAHIWACPPSEGDDYIF...HCHPTDQKIPKPKRLQEWYKK
 2112- 2162 (71.68/43.36)	IIQDYKDILKQaMEDKLGSAAELPYFEGD...F...WPNVLEESIKELDQEEEEKRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.95|      16|      17|     177|     192|      14
---------------------------------------------------------------------------
  177-  192 (30.84/15.73)	NNGNNGMNSIPGMNSI
  196-  211 (29.11/14.33)	NLGNMVLTNSGGMGTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.83|      11|     469|    1475|    1486|      15
---------------------------------------------------------------------------
 1475- 1486 (17.16/ 9.42)	ENSApG....RVMSSS
 1948- 1962 (14.67/ 6.70)	EASA.GevhiRVVSSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25166 with Med15 domain of Kingdom Metazoa
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