<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25159

Description Uncharacterized protein
SequenceMDYDFKMKTQMERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVIALIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKHVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLIKDFKRSTYSACSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDPYFQEEPLPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQMNPNEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQIIFNQQQNFQQRFN
Length458
PositionKinase
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.09
Grand average of hydropathy-0.890
Instability index56.54
Isoelectric point8.77
Molecular weight54102.75
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25159
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.42|      15|      15|     373|     387|       1
---------------------------------------------------------------------------
  373-  387 (35.61/11.24)	QQQQQQQQQQ....QQQ..QQ
  389-  403 (35.61/11.24)	QQQQQQQQQQ....QQQ..QQ
  435-  455 (25.21/ 6.21)	QQQQQQQQQQiifnQQQnfQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.82|      38|      40|     235|     273|       2
---------------------------------------------------------------------------
  235-  273 (66.34/55.74)	HCRQEDIKTSNpYHHDQLDRIFNVMGF.PQDKDWEDIKKM
  277-  315 (60.49/44.58)	HTLIKDFKRST.YSACSLAKYMERHKIkPDSKAFHLLQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.90|      25|      40|     102|     129|       3
---------------------------------------------------------------------------
  102-  129 (41.05/32.17)	HDLWhiiKFHRAAKATKKHVV...VPRGMVK
  143-  170 (40.85/24.05)	HSNW...VLHRDLKPANILVMgdgNERGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.99|      12|      18|     333|     344|       4
---------------------------------------------------------------------------
  333-  344 (24.34/14.22)	PYFQEEPLPTQD
  352-  363 (23.64/13.61)	PYPKREFLTDDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25159 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNKRITSEQAMQDPYFQEEPLPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQMNPNEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQIIFNQQQNFQQRFN
320
458










Molecular Recognition Features






MoRF SequenceStartStop




1) EPNAKRVRLS
410
419