<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25157

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGNHPKNSGGAGYSSQAPITISIPSIEQKNKQMQQETLMERLRAKYRNKPKSYEEIKKSVRMYFIEKHYPLDPLCKAALQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQTLFISTDMFYVEILLDASGNLSDVKVHHECKIEQQSSSSASSTELLNCLRAGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIFSLYQHQLQLQQQLSSSTDSYHIMNNSSVGLVLQRRGGHPVKLTYFCPPLHLIEKKVKGEKVATSSGTASRDLSIEQVIKSPNGLSVTLNLEASSANKLQILPIVSITNEAGLPLEQPVYAPLTQNNSMLMPATYVLRLSKPMPVCIESLRALGLPGLTSNANEETPTVMNLIVQTASRQLIRNTQKGLYVNLPKETHCYFFTDNHRLKGTMISSLPFTEPAQVPKIIAFLKKQALFYTLLSSCIREQQKQYNDMDSTVILEVTAVSLSLITVELQHPYEESLATVDFLLEDGQVTCTIYSVNDEYEALSEKLTRTVRQVLSIPMVIYKLLKCWDEEHQKKMHGNLAPGAGTGSGASGGFSGTGGGVGGGSGGMHGASNFGQFAIDAAGEGGSGTGGGFSSLANLKMDSKVRSLADAFAASTSAAAAIAGLISLKRETDPQSSGGSSPVPPSSSGLDSKATEHEIADKYKNIWKDKTPNLKHCVSITPIAGDGKSPLQQQQQQQQQQVDVQRTGGIEIIPLNAAASVGATPSTGSAATTITITPITGGAKEAGKEAKKPIPTGGATKRPHEGTSSSSSSSGTGSSASSDAQKEKKRKKKRDDSPMGPPEKVYSRQNSPASGGMTEASAGGGVARKFSSPSTSSSSSPKGGSASAAAALGLMAGQPSARPSPKHSPVYSSPKHNSSSNTASNSPKSPFGTLSPKHGSSGKPSMSTLKSATAATGLSLSPKGEKSITGAGGGSSIPLSTAGSGSGSGLGSSGNPSMLRPVPPLASSSQLPAAIKKDKSIASSSASTAPSGVAAAVAALKSSQQQQQQQQQQQQQQLKSPVASLSHLAAGGNLSSYGAPAVAALELNALRKGMAGAGVGSGLGAAAGAVGAVSPFSIYE
Length1096
PositionMiddle
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.05
Grand average of hydropathy-0.337
Instability index56.70
Isoelectric point9.28
Molecular weight114868.40
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25157
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     644.99|     186|     311|     552|     763|       1
---------------------------------------------------------------------------
  560-  617 (22.05/23.60)	.................................................................................................................................................................................AGTGSGaSGGFSGTGGGV.........GGGSGGMH.GASnfgqfaidaAGEGGSGTGGGFSSLANLKM
  618-  803 (259.93/131.14)	DS......KVRSLADAFAASTSAAAAIAGLISlKRETDPQSSGGSSP..VPPSSS.....GLDSKATEHEIADKYKNIWkdKTPnlKHCVSITPIAGDGKSPLQQQQQQQQQQvdvQRTGGIEIIPLNAAASVGATPSTGS.............AATTITITP.....ITGGAKEAG..................keakkpiptGGATKRPHeGTS.........SSSSSSGTGSSASSDAQ.KE
  812-  974 (207.01/90.69)	DSpmgppeKVYSRQNSPASGGMTEASAGGGVA.RKFSSPSTSSSSSP..KGGSASaaaalGLMAGQPSARPSPKHSPVY..SSP..KHNSSSNTASNSPKSPF................GTL.............SPKHGSsgkpsmstlksatAATGLSLSPkgeksITG......AGGGS..SIPLSTAGSG.............SG................SGLGSSG.........NPSM
  975- 1090 (156.00/64.62)	LR......PVPPL....ASSSQLPAAIK.....KDKSIASSSASTAPsgVAAAVA.....ALKS....................................SQ.QQQQQQQQQQ...QQQLKSPVASLSHLAAGGNLSSYGA............pAVAALELNA.....LRKGMAGAG..VGSG....LGAAAGAV.........GAVS.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.32|      50|      70|     146|     196|       2
---------------------------------------------------------------------------
  146-  196 (80.91/64.88)	HHECKIEQQSSSSASSTELLNCLRAG....DFADFTVQLEGLSSIYQLnAEPKVK
  215-  268 (84.41/62.48)	QHQLQLQQQLSSSTDSYHIMNNSSVGlvlqRRGGHPVKLTYFCPPLHL.IEKKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.56|      17|      37|     276|     292|       3
---------------------------------------------------------------------------
  276-  292 (28.24/16.82)	SGTASRDLSIEQVIKSP
  316-  332 (30.32/18.61)	SITNEAGLPLEQPVYAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25157 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVAALKSSQQQQQQQQQQQQQQLKSPVAS
2) CVSITPIAGDGKSPLQQQQQQQQQQVDVQRTGGIEIIPLNAAASVGATPSTGSAATTITITPITGGAKEAGKEAKKPIPTGGATKRPHEGTSSSSSSSGTGSSASSDAQKEKKRKKKRDDSPMGPPEKVYSRQNSPASGGMTEASAGGGVARKFSSPSTSSSSSPKGGSASAAAALGLMAGQPSARPSPKHSPVYSSPKHNSSSNTASNSPKSPFGTLSPKHGSSGKPSMSTLKSATAATGLSLSPKGEKSITGAGGGSSIPLSTAGSGSGSGLGSSGNPSMLRPVPPLASSSQLPAA
3) GLISLKRETDPQSSGGSSPVPPSSSGLDSKATEHEIADKYKNI
1011
693
640
1040
990
682










Molecular Recognition Features






MoRF SequenceStartStop




1) GKEAKKPIP
2) KEKKRKKKR
3) KSATAAT
4) LPAAIKKDKSIA
763
802
926
987
771
810
932
998