<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25156

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSKSHSKSGAGYSGKPPKTISIPSIEQKNKQMQQETLMERLRAKYRNKPKSYEEIKKSVRMYFIEKHYPLDPLCKAALQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQTLFISTDMFYVEILLDASGNLSDVKVHHECKIEQQSNSSASSTELLNCLKAGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIFSLYQHQLQLQQQLSSSTDSYHIMNNSSVGLVLQRRGGHPVKLTYFCPPLHLIEKKVKGEKVATSSGTASRDLSIEQVIKSPNGLSVTLNLEASSANKLQILPIVSITNEAGLPLEQPVYAPLTQNNSMLMPATYVLRLSKPMPVCIESLRALGLPGLTSNANEETPTVMNLIVQTASRQLIKNTQKGLYVNLPKETHCYFFTDNHRLKGTMISSLPFTEPAQVPKIIAFLKKQALFYTLLSSCIREQQKQYNDMDSTVILEVTAVSLSLITVELQHPYEESLATVDFLLEDGQVTCTIYSVNDEYEALSEKLTRTVRQVLSIPMVIYKLLKCWDEEHQKKMHGNLAPGAGTGSGASGGFSGTGGGVGGGSGGMHGASNFGQFAIDAAGEGGSGTGGGFSSLANLKMDSKVRSLADAFAASTSAAAAIAGLISLKRETDPQSSGGSSPVPPSSSGLDSKATELEIADKYKNIWKDKTPNLKHCVSITPIAGDGKSPLQQQQQQQQQQQVDVQRTGGIEIIPLNAAASVGATPSTGSAATTITITPITGGAKEAGKEAKKPIPTGGATKRPHEGTSSSSSSSGTGSSASSDAQKEKKRKKKRDDSPMGPPEKVYSRQNSPASGGMTEASAGGGVARKFSSPSTSSSSSPKGGSASAAAALGLMAGQPSARPSPKHSPVYSSPKHNSSSNTASNSPKSPFGTLSPKHGSSGKPSMSTLKSATAATGLSLSPKGEKSITGAGGGSSIPLSTAGSGSGLGSSGNPSMLRPVPPLASSSQLPAAIKKDKSIASSSASAAPSGVAAAVAALKSSQQQQQQQQQQQQQQLKSPVASLSHLAAGGNLSSYGAPAVAALELNALRKGMAGAGVGSGLGAAAGAVGAVSPFSIYE
Length1093
PositionMiddle
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.05
Grand average of hydropathy-0.340
Instability index55.77
Isoelectric point9.33
Molecular weight114643.37
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25156
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.71|      30|      30|     567|     596|       1
---------------------------------------------------------------------------
  568-  599 (48.50/18.43)	FSGTGGGVG...GGSGGMHGASNFGQFAIDAA.geG
  837-  868 (26.48/ 6.54)	...AGGGVArkfSSPSTSSSSSPKGGSASAAA.alG
  886-  914 (29.73/ 8.29)	YSSPKHNSS...SNTASNSPKSPFGTLS....pkhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.23|      44|      46|     653|     696|       2
---------------------------------------------------------------------------
  615-  663 (48.22/21.15)	MDSKVR.SL..ADAFAASTSAAAAiagliSLKR..ETDP..qssgGSSPV.....PPSSSG
  664-  716 (61.90/29.20)	LDSKAT.ELEIADKYKNIWKDKTP.....NLKHCVSITP..iagdGKSPLqqqqqQQQQQQ
  717-  757 (33.45/12.45)	VDVQRTgGIEI......I.....P....lNAAASVGATPstgsaaTTITI.....TPITGG
  758-  790 (34.67/13.17)	..AKEA.GKEAKKPIPTGGATKRP........H.........egtSSS........SSSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.78|      20|      25|     917|     940|       3
---------------------------------------------------------------------------
  918-  939 (25.47/15.10)	KPSMSTLkSATAATGlSLSPKG
 1032- 1051 (28.31/ 7.39)	KSPVASL.SHLAAGG.NLSSYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.21|      13|      26|     455|     467|       7
---------------------------------------------------------------------------
  455-  467 (23.52/16.65)	EQQKQYNDMDSTV
  482-  494 (22.69/15.78)	ELQHPYEESLATV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.34|      26|      48|     940|     966|       8
---------------------------------------------------------------------------
  940-  966 (41.43/24.21)	EKSITGAgGGSSIPLSTAGSGSGLGSS
  991- 1016 (38.91/17.99)	DKSIASS.SASAAPSGVAAAVAALKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.48|      14|      26|     410|     423|      10
---------------------------------------------------------------------------
  410-  423 (25.22/18.50)	FTDNHRLKGTMISS
  438-  451 (23.26/16.45)	FLKKQALFYTLLSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25156 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CVSITPIAGDGKSPLQQQQQQQQQQQVDVQRTGGIEIIPLNAAASVGATPSTGSAATTITITPITGGAKEAGKEAKKPIPTGGATKRPHEGTSSSSSSSGTGSSASSDAQKEKKRKKKRDDSPMGPPEKVYSRQNSPASGGMTEASAGGGVARKFSSPSTSSSSSPKGGSASAAAALGLMAGQPSARPSPKHSPVYSSPKHNSSSNTASNSPKSPFGTLSPKHGSSGKPSMSTLKSATAATGLSLSPKGEKSITGAGGGSSIPLSTAGSGSGLGSSGNPSMLRPVPPLASSSQLPAA
2) GLISLKRETDPQSSGGSSPVPPSSSGLDSKAT
691
638
987
669










Molecular Recognition Features






MoRF SequenceStartStop




1) AGKEAKKPIP
2) EKVYSRQ
3) KSATAAT
4) MSKSHSKSGAGYSGKPPKTISIPS
5) QKEKKRKKKRDD
6) SQLPAAIKKDKSIASS
761
818
925
1
800
982
770
824
931
24
811
997