<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25149

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEEWQSQNFRQNVISKIHDVLPQNAPDQNKNASIMENHIFRKSRTKDEYLGLVAKLFMHYKDVSRKSQAQQQQQQQQQLQQQQQQQQQQQPPPNAEMGQQNIMQDPLNALQNLASQGNRNPQLMPMGGAPGPNQMAGPGGPGTASNLLQTLNQQRPGQQQMQPMPNIRGQLPMGAGAGGQQMVQVQQMAGGNGPGGAGGMQLNAMGPAVAQGQGQIVGNAGGMPNQMVGPGPNSGPTGGATGGMPNQMSPMVMGMGNPMMRLNQGMQGMPSNMQQQHNVVGGPAGQQQVGGPGGLPPNAVQQGGAMNPLNGMTVNMPPNMQQKPNMTMGQAGQMFPGNRGGVVGGQQQPQQPFMRSSPSPADAQQLQQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMLQNQQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLGKITNDGTNVEKMTKMSKLLEILCNPTQRVQLDTLLKCEKALEKMDLVSYSGQQFGKSSNPLLEVINTTLQSPLANHTLHRTFRPSLELLFGTDICAPVAPKKPHLEEKSSPFEQEVPHVLQGEIARLDTKFKVKLDTTAQNNNRAIRLICCLDDKCLPSVPPVSVSVPEEYPWQSPDCSLTEQEYSATPFLQTVQQALIARMSKLPKNYSLSHLLDTWEMAVRQACSPQAKPRAMCELTTLLGV
Length707
PositionTail
OrganismDrosophila mojavensis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.03
Grand average of hydropathy-0.681
Instability index64.89
Isoelectric point9.14
Molecular weight76915.94
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25149
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     332.51|      44|      44|     244|     287|       2
---------------------------------------------------------------------------
  118-  163 (56.51/13.62)	G.NRNpQL..MPM.GGAPGPNQMA.GPG...GP.GTAS.NLL..QTLNqqRPG..QQQMQ
  223-  240 (37.15/ 6.24)	G.MPN.QM......VGPG.P...................N......S........GPTGG
  244-  287 (90.73/26.66)	G.MPN.QM..SPMVMGMGNPMMRL.NQG...MQ.GMPS.NMQ..QQHN..VVG..GPAGQ
  291-  334 (68.19/18.07)	G.GPG.GL..PPNAVQQGGAMNPL.N.G...MTvNMPP.NMQ..QKPN..MTM..GQAGQ
  342-  381 (39.71/ 7.22)	GvVGG.QQ..QPQ.....QPFMR....S...SP.S.PA.DAQqlQQQQ..LVGnqTPTQQ
  386-  438 (40.21/ 7.41)	Q.MPTpQMipSPALVPQSSPQMMLqNQQrniRQ.QSPSaSIN..TPGQ..VTG.nSPFNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.87|      27|      69|       6|      38|       3
---------------------------------------------------------------------------
    6-   32 (46.66/14.01)	QSQNFRQNVISKIHDVLPQNAPDQNKN
   76-  102 (48.21/13.93)	QQQQLQQQQQQQQQQQPPPNAEMGQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.82|      32|      82|     569|     600|       6
---------------------------------------------------------------------------
  521-  550 (29.62/12.82)	...SNPLLEVINTTLQSPLANhtLHRTFRPS..LE.
  569-  600 (51.52/26.89)	EEKSSPFEQEVPHVLQGEIAR..LDTKFKVK..LDT
  647-  680 (45.69/23.14)	EYSATPFLQTVQQALIARMSK..LPKNYSLShlLDT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25149 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KDVSRKSQAQQQQQQQQQLQQQQQQQQQQQPPPNAEMGQQNIMQDPLNALQNLASQGNRNPQLMPMGGAPGPNQMAGPGGPGTASNLLQTLNQQRPGQQQMQPMPNIRGQLPMGAGAGGQQMVQVQQMAGGNGPGGAGGMQLNAMGPAVAQGQGQIVGNAGGMPNQMVGPGPNSGPTGGATGGMPNQMSPMVMGMGNPMMRLNQGMQGMPSNMQQQHNVVGGPAGQQQVGGPGGLPPNAVQQGGAMNPLNGMTVNMPPNMQQKPNMTMGQAGQMFPGNRGGVVGGQQQPQQPFMRSSPSPADAQQLQQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMLQNQQRNIRQQSPSASINTPGQVTGNSPFNPQEEAL
2) QNVISKIHDVLPQNAPDQNKNASIMENHIFRKSRT
62
12
443
46










Molecular Recognition Features






MoRF SequenceStartStop




NANANA