<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25138

Description GH23935
SequenceMNQNQIQQLTSHLSQALDPNYDVINMEAVLAVICTLEGTTITKEQLEATRLAKYINQLRRRTKNDQLARRAKSLLKKWREMVGINQTSSDSQPAITTTATINKPINESIIIVDNVVHPQLSVSASASTSSSSFMPEASNFSLNHLDNSVDFSSFKPKSDIDKSNEPPIVIDIVSDSDENENEARIQSNINRSSFASASSQQQPQQQQAFPAFYPRPKKLKKEKKSRKEREKLATTTATNLLTYLKDDLPLQMPRSIIRNNLAQQQPQQLGRKIYPTDSEILSLSNSSMSSILSGDNTLNNNRSRSNAADLTFAGRFKSLTQFEDNNNPPPVSVNGQKKPEPEQQQQQLYEDYMLHNDSSNSVSRLSPFEEQSIPISHNEGSNKQMPAVNKPQDYQRSENILSQVPKKRGRKKGSKGVDSLIAKESSSLSQQIFFNSGVKKVKTTKELFNDIQSRKLSISYRGDSALPASASVSAAASKLNNRDARPTSSCSETSLHSPHNLETFSTNASQLGNDKFSTILEASVHTDSETLTSAEPSRRHSLEDSNSNNSQQTISATSRLINTECDHDAESRTHSPLSRMNLNHSAGGNYDVSNQLMQLIRSLNAPLSVSETERLYRSQIVPCTCLIFEDAPKLNPTNDENSNNNNNNELNSETVEDHRERGQQQQTESINRNIDNQQKKLTAAADADVTKIMPTSIAPSKPIKSIFDLDFDDDDDPMQSIMQKIPDRNAPNTNEPNELKSTTTNEVNNLHSVVDLQMESDPGNNQTELVPLSIYTVHEDPDCLARQRFEIQTNKVTTFHINALHNYYVPNINGNWNNTGNYGNWNSRINDQTYSVRDGSDVVPKYGSLTYEMIRKDLSELKFKQNLNVKRDGKKMKNYLPTFLGVAKCLPTCRRRAAREWNEMSLKRAASRQQIKSGPSPLRVHIDNANDNNVIADQADGYNLLKVAQEADTKLSYVASELSITNRTSNRCNSSSNNSDCSNFSSQQTQNSINAKVRIRRTSEQVAERHVIERNRKKRRKANRYEQEQQQQLSINEKPRIKRIKIAINGQLPHISNYSSSSCNNSSDEQDEQREEEQDQNEQQEEQNEQQQEEQGEQKRQYRNMQDQNEQQEPEEDNGHETRNKLSNDCQRMLQTVASEDEEDDDDERASLRSRSTTLDEDAVVLEHEYDNDNNDNEYAIIRRGGNNGNNHLVLTIKKTPSKINSPVNSISANISPNIVVAVVKTQNDADNSEGVQKEQQQMTQQATMAATPSCLHNVERCYRYRRRHHRHRYRRPPIDITLKHLFNNNNNNNNSVKQLHRKLFFTNELKFENASGQKERLLNYSSSSSDDSSELETELEAAAAHNYKLKNETDQSVRIAANIHTDYENDEQLCLNTDDDEEEEVDDESEDEAVAAGEEEDEGKAGADAADEGRAASEIIKVSAEIDAANDVTTLAELRLDNNNDMLPTFNSIYAKQIQQQRNNETCEEHNNNFKCGVMQQTTLATTAASNMLEASCEKRLQPALENITGMRAVLLDVDVNVQEDAEAEQLKTDKKRLQQQQFKEWHQVLQLQSYNEEPLIVLPYVVLE
Length1570
PositionUnknown
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.05
Grand average of hydropathy-0.989
Instability index56.49
Isoelectric point5.35
Molecular weight177428.66
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25138
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     256.28|      58|      58|    1026|    1083|       1
---------------------------------------------------------------------------
  641-  706 (55.24/19.29)	NSNNN........NNNELNSEtvEDHR.ERGQQQQ......T....EsinrnidNQQKKLTA.......................AADADVTKImPTSIAPskPIKSI.
  966- 1002 (37.53/10.97)	NRTSN......RCNSSSNNSD.....................csnfS.......SQQTQNSI.......................NAKVRIRRT...............
 1003- 1056 (62.36/22.64)	..S..............EQVA..ERHVIERNRKKRrkanryE....Q.......EQQQQLSI.......................NEKPRIKRI.KIAING..QLPHIS
 1057- 1100 (56.34/19.81)	NYSSS......SCNNSSDEQD..EQREEEQDQNEQ....qeE....Q.......NEQQQEEQ.......................GEQKR...................
 1214- 1287 (44.82/14.39)	NISPNivvavvKTQNDADNSE.......................gvQ.......KEQQQMTQqatmaatpsclhnvercyryrrrHHRHRYRRP.PIDIT....LKHLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.63|      26|      26|    1123|    1148|       2
---------------------------------------------------------------------------
  734-  763 (36.21/24.31)	NEPNELKSTTTnevnNL.HSVVDLQMESDPG
 1121- 1146 (39.03/26.93)	ETRNKLSNDCQ....RM.LQTVASEDEEDDD
 1147- 1173 (35.39/23.54)	DERASLRSRST....TLdEDAVVLEHEYDND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.86|      18|      18|    1367|    1384|       3
---------------------------------------------------------------------------
 1367- 1384 (31.36/16.91)	DYENDEQLCLNTDDDEEE
 1388- 1405 (26.49/13.07)	DESEDEAVAAGEEEDEGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.46|      24|      61|     106|     165|       4
---------------------------------------------------------------------------
  131-  157 (37.72/79.14)	SSFmpeASNFSLNHLDNSVDFSSFKPK
  192-  215 (44.75/10.09)	SSF...ASASSQQQPQQQQAFPAFYPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     263.92|      78|      83|     441|     523|       5
---------------------------------------------------------------------------
  441-  488 (61.02/23.45)	................................VKTTKELFNDIQ.SRKLSIS.....YRGDSALPASASVSAAASKLNNRDARPTS
  492-  569 (111.62/57.82)	ETSLHSPhnLETFSTNASQLGNDKFSTILEASVHTDSETLTSAEpSRRHSLE........DSNSNNSQQTISATSRLINTECDHDA
  570-  635 (91.29/37.08)	ESRTHSP..LSRMNLNHSAGGNYDVSNQLMQLIRS...LNAP......LSVSeterlYRSQ.IVPCTCLIFEDAPKLN........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      13|      16|     244|     256|       6
---------------------------------------------------------------------------
  244-  256 (23.33/13.31)	LKDDLPLQMPRSI
  261-  273 (21.11/11.23)	LAQQQPQQLGRKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.25|      10|      16|     158|     168|       7
---------------------------------------------------------------------------
  158-  168 (14.72/13.48)	SDiDKSNEPPI
  176-  185 (17.53/ 9.90)	SD.ENENEARI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.10|      16|      26|     327|     343|      10
---------------------------------------------------------------------------
  327-  343 (26.63/19.11)	NPPPVSVNgQKKPEPEQ
  356-  371 (25.47/12.58)	NDSSNSVS.RLSPFEEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.02|      18|     242|      55|      74|      19
---------------------------------------------------------------------------
   42-   59 (28.34/23.22)	TKEQLEATRLAKYINQLR
   62-   79 (29.68/16.16)	TKNDQLARRAKSLLKKWR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25138 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APKLNPTNDENSNNNNNNELNSETVEDHRERGQQQQTESINRNIDNQQKKLTAAADADVTKIMPTSI
2) ENDEQLCLNTDDDEEEEVDDESEDEAVAAGEEEDEGKAGADAADEGRAASEIIKVS
3) GQKERLLNYSSSSSDDSSELETELEAAAAHNYKLKN
4) HTDSETLTSAEPSRRHSLEDSNSNNSQQTISATSRLINTECDHDAESRTHSPLSRMNLNHSAGGNYDVSNQLM
5) IKSIFDLDFDDDDDPMQSIMQKIPDRNAPNTNEPNELKSTTTNEVNNLHSVVDLQMESDPGNNQTELVPL
6) IVVAVVKTQNDADNSEGVQKEQQQMTQQATMAA
7) NENEARIQSNINRSSFASASSQQQPQQQQAFPAFYPRPKKLKKEKKSRKEREKLATTTAT
8) RTSNRCNSSSNNSDCSNFSSQQTQNSINAKVRIRRTSEQVAERHVIERNRKKRRKANRYEQEQQQQLSINEKPRIKRIKIAINGQLPHISNYSSSSCNNSSDEQDEQREEEQDQNEQQEEQNEQQQEEQGEQKRQYRNMQDQNEQQEPEEDNGHETRNKLSNDCQRMLQTVASEDEEDDDDERASLRSRSTTLDEDAVVLEHEYDNDNNDNEYAIIRRGGNNGNNHLVLTIKKTPSKINSPVNSI
9) SASVSAAASKLNNRDARPTSSCSETSLHSPHNLETFSTNA
10) SNSSMSSILSGDNTLNNNRSRSNAADLTFAGRFKSLTQFEDNNNPPPVSVNGQKKPEPEQQQQQLYEDYMLHN
11) SNSVSRLSPFEEQSIPISHNEGSNKQMPAVNKPQDYQRSENILSQVPKKRGRKKGSKGVDSLI
631
1369
1317
525
703
1219
179
967
469
284
359
697
1424
1352
597
772
1251
238
1211
508
356
421










Molecular Recognition Features






MoRF SequenceStartStop




1) EYAIIRRG
2) KERLL
3) PAFYPRPKKLKKEK
4) SIMQK
1178
1319
210
720
1185
1323
223
724