<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25136

Description GH17865 (Fragment)
SequenceGARSPRYSLQLDYSIDFFKTYIDTQRFYAGHKLDFKHQSCAGGPGSGGGGAAGVVGVVGNTNNNNSNNNNNSSSNNSNNSNNNNNSGNTNSQQQHLQQQQQQQQQQQQHTQQQQHTQQQQQQQQQQQALPANGSNNNSHAHSHAHALAHAHQLHTVLPLQQQQQQQQQQQQQLPAGAASLQQQQLPQQQQQQQQQQLLNSNNNSNSNIVGVVTPTLIIGNGPGSEGHTVSGATTVAASAATAAAAAAAAAAAASASASSVSVATSASLPHVASHSLGLSPQSSADSQQFNIFPAIFSRQLNFSAAGACGQAGKLSMDELRPNLVGGLLGLQQAGLLEDHANSMQHGGVAQDTKFMSFQDNRLMGISGSHENRLLSLASSVQDTRSPITTLDKSSSSSLNHQRKCSSTPEDFSALYSGLPTPGMDSSSHHHTPAHTPPSRLSDHTISAEGAFKKLKPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVIPSCNGMMRNIQGYSVSRGYQPYPHHNTMNRYPQDLFQMGASSYPGMTQPFSMAHSTNMGSVGVRQDSMEYQKKKMFIQSTLELISLSLSVSLSPSLSLSLSGIPYIFPGMSPEDEWYNKSLSALRMNSSHHPNLSAPMLQYQT
Length711
PositionKinase
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.05
Grand average of hydropathy-0.701
Instability index56.34
Isoelectric point9.14
Molecular weight76620.36
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25136
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     127.32|      15|      18|      92|     106|       1
---------------------------------------------------------------------------
   92-  106 (34.45/13.38)	QQQH....LQQQQQQQQQQ
  112-  126 (33.87/13.03)	QQQH....TQQQQQQQQQQ
  151-  169 (26.83/ 8.80)	HQLHtvlpLQQQQQQQQQQ
  181-  195 (32.17/12.01)	QQQQ....LPQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.22|      18|      19|     309|     326|       2
---------------------------------------------------------------------------
  309-  326 (31.76/22.20)	G..QAGK.LSMDELRPNLVGG
  329-  347 (25.42/16.10)	GlqQAGL.LE.DHANSMQHGG
  349-  367 (25.04/15.73)	A..QDTKfMSFQDNRLMGISG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.78|      13|      18|      60|      72|       3
---------------------------------------------------------------------------
   60-   72 (25.95/12.60)	NTNNNNSNNNNNS
   79-   91 (26.83/13.26)	NSNNNNNSGNTNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.40|      19|      22|     261|     279|       4
---------------------------------------------------------------------------
  261-  279 (31.23/18.60)	SVATSAS...LPHVASHSLGLS
  282-  303 (26.17/14.23)	SSADSQQfniFPAIFSRQLNFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.27|      17|      19|     574|     591|       5
---------------------------------------------------------------------------
  574-  590 (34.68/24.34)	MMRNIQ.....GYSVSRGY.QPY
  596-  618 (25.60/10.13)	MNRYPQdlfqmGASSYPGMtQPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     171.64|      47|      52|     386|     432|       6
---------------------------------------------------------------------------
  386-  421 (51.95/25.46)	................PITTLDKSSSSSLNHQRKCSSTPE.DFSALYSGLPTP
  422-  472 (70.52/37.22)	GMDSSSHH..HTPahtPPSRLSDHTISAEGAFKKLKPEPNsGLSTVSAGITSP
  475-  512 (49.16/23.70)	GLSSLSQHagHTP.....TT..ASCPTPARRRHRTTFTQE.QLAEL.......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25136 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PEDFSALYSGLPTPGMDSSSHHHTPAHTPPSRLSDHTISAEGAFKKLKPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASCPTPARRRHRTTFTQEQL
2) RFYAGHKLDFKHQSCAGGPGSGGGGAAGVVGVVGNTNNNNSNNNNNSSSNNSNNSNNNNNSGNTNSQQQHLQQQQQQQQQQQQHTQQQQHTQQQQQQQQQQQALPANGSNNNSHAHSHAHALAHAHQLHTVLPLQQQQQQQQQQQQQLPAGAASLQQQQLPQQQQQQQQQQLLNSNNNSN
408
26
509
205










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAAA
243
249