<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25134

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMANRQMAQPPENHLRLSWHDTQMIATLSPQTVMDYFCRKSNPFYDHMCNNETIRMQRLGVEHLHNMLGLEYILLHVAEPILYVIRKQHRHNPAEATPIADYYIIGGTIYKAPDLANVINARVLNTVVNLQSAFEEASSYARYHPNKGYTWDFSSNKILSDKSKADKKDSSATKDDSSGTLFQKQRVDMLLAELLRKFPPPIPPMLQNLQPAGQLPNAAGADGGTATNSTENHANGPLDIATESIDMKPPPEKKSK
Length255
PositionHead
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.07
Grand average of hydropathy-0.579
Instability index46.16
Isoelectric point7.16
Molecular weight28610.16
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	PIRNR:PIRNR023869
GO - Cellular Component
cytoplasm	GO:0005737	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblMetazoa
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25134
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.71|      31|      55|     158|     188|       1
---------------------------------------------------------------------------
  158-  188 (50.30/30.87)	LSDKSKAD.KKDSSATKDDSSGTL.FQKQRVDM
  214-  246 (43.41/25.81)	LPNAAGADgGTATNSTENHANGPLdIATESIDM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25134 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PIPPMLQNLQPAGQLPNAAGADGGTATNSTENHANGPLDIATESIDMKPPPEKKSK
200
255










Molecular Recognition Features






MoRF SequenceStartStop




1) LDIATESIDMK
2) PEKKS
3) QRVDMLLAELLRKF
237
250
184
247
254
197