<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25131

Description GH13270
SequenceMSIAAAENAGLSPGDLPDHWASGTATTHGAAAATSNKHNSNINININSYNNSNSSSNSNSNINNNHNHSACNPRSSPAAATAAVTISATGGSVVTGPGPVPAPVAQLQHGLAPSTPLQRATAASGGGAVGAGAAAAAAASNLLTLQQQQQQQQLLYQQQQQHQHQQHHPHQQQQQQQHQQQQQPLHQQLNSATARIAAALQRSPAMNAVASPIPANSATSARKIRRKTDTKINLPQSQINKCNNEKRRREMENNYIEQLSEFLQLNKRGDMTSTKPDKAAILNQVVRTYRDICDKGQSRDISSTSTNNNNNSTTTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNSHKPQATSTRCTRCATDNCSIHPVQQGEVSSTEPPLPEPSLLNGQVPEISAYFEALEHYISSVGWVLLQVNANGIIESCTQNIRELIGYEKHELFHQPLYMYLYSGDHAKLEPIINNMYSSSSNSNNSGGGGSGGGNSSATGGVWGDLDELNNGNASQQSASSNSSSSAGNGAGPGPGGGGSGIVASKSKRSISTKVRMLVKDTRPATQTSSSSSSSSSNCGDAMDQKPLRQSGHQDKYEEVVLIAAPVKDDADASSSVLCLITRPEDESPLEINIQQHVHHQPTEEMTFKLDVHGKILSLDATALRDPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDIQDSAVVHSPGSSANASNSGGNPGSGGGGGSISNVISRPFRLRLGAPDVYVHVKANSRLFLNHTPGESDFIMSVQTLLNSENDMNSNNTGAGSGGATAGLSLGLSQMCAMSPGAHLASTLVNTLSMEVLGHSSTSSSTSSAAAMLPTHLLGGLVGGGGSNTQTTNVGGPLMSSAILNGSGMQQRLGNSGASGGNASSAATLVNAFTASPAPGEHSFYGSDAFEFDIAHSSFDMDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAGAGGSSSYGFNFHSYDPADSKPDKEQQQQQQQTANNNANNSNSSSNNNSALIGVGLPNGVGGLLLTSQQQQQQQQQQQQTPPLQESSERLRHLLTKSQAGGLGDEEKYFKQECNEDEKLNVGSVVGPAGSFKLGGQMGLFGPLVGRGAANAALLQKAGNSQNPMLLKLLNEKSEEDDGSGAGGTGAGSGTGGPGMLNNVRQSELMRQLQKDDGGGHGHGHGMLGGGSGGGGGSGGAGGGANMSNEDLKRMLKIQSDPAMSRKRSLNEPDVDIAVKRSEDKPSKLCSENKMLAKLLQNPIKLPKAPNPEQPLQVKTLPDITSSSVNSVSSSLSVPGNLISAASQSGPKAATATTAAANSRARKQQQQLQQQQQQQQQQQQLQQQHQQQQQHQQQHQQQQQSTVQQNDIYLSQQQQQQLAYQQQQQQLATTATTSNQTIAASTSTSAGAPDPELSKLLDSFMDYYPDDTPIGSAAPSEASAISDIQKSLMLDVETAAFGVLHAMNPQLIMSQQQHQQLLAQQQQQQQQQQQQQQQQQQQQQQRQQHLQPPAYPGMLGLQQQHQQQQQQQQQQHQQQQQQQHLIRQQQRQQEHLMEAGRFQRPPPIYQARGRGPMNAVATPGGCVVLPNQQMRNMRQQQQQQKERLLQQQQKQQLLVPENATGINAGINNIGSLLNTTVAPNVSLSRTNLPADAQLSPNFAQTLMQQQLSPGRSAPYSPQPNQGYGPQFAQNAQRLSPQQQQQQNPQQQQLAYLQQQQQQQAGDGGRSNTPFGSGSGMQSPGMQSSPQQWTTVAGGAAGGVAGAVGGGPGGPLPAGNASRSQQQHNNPLLIAQLQNNFNARQYQQQQQQQQQQQRRGLNSPGAVGPVGNAAAVLQRQNSFQAQGGSGASTPDGSSGPVGLSFGGGPQSPYGGGAPGNAFQQQQLQRLQRQGSVPQATQHLPAGNAGGGGGGGGNANSDFVKQELRAVVSVRAQQAAAAATGGGVGVGGAGVAQRGQTPQSPLQQGPMIGGSGNSTNSMGGNATPTGTGSTGNPMLNTPPDPTLGFSFETPDFFTSSATR
Length2039
PositionTail
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.03
Grand average of hydropathy-0.773
Instability index63.72
Isoelectric point8.07
Molecular weight214415.68
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:InterPro

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	IEA:InterPro
protein dimerization activity	GO:0046983	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25131
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     192.71|      15|      15|    1497|    1511|       1
---------------------------------------------------------------------------
  157-  171 (29.30/ 7.13)	QQQQQHQHQQ.HHPHQ
  172-  186 (33.76/ 9.32)	QQQQQQHQQQ.QQPLH
 1051- 1065 (34.42/ 9.65)	QQQQQQQQQQ.QQTPP
 1351- 1364 (34.64/ 9.76)	QQQQQQQQQQ.QQ.LQ
 1365- 1378 (31.51/ 8.22)	QQHQQQQQHQ.QQ.HQ
 1502- 1517 (29.08/ 7.03)	QQQQQQQQQQqQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.51|      12|      15|     317|     328|       2
---------------------------------------------------------------------------
  317-  328 (27.25/10.81)	NNNNNNNNNNNN
  333-  344 (27.25/10.81)	NNNNNNNNNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     149.86|      22|      24|     840|     861|       3
---------------------------------------------------------------------------
  688-  709 (34.59/12.75)	SAVVHSPGSSANASNSG..GNPGS
  837-  856 (29.83/ 9.69)	..LVGGGGSNTQTTNVG..GPLMS
  857-  880 (29.90/ 9.74)	SAILNGSGMQQRLGNSGasGGNAS
 1185- 1202 (27.13/ 7.95)	SELMR....QLQKDDGG..GHGHG
 1203- 1216 (28.40/ 8.77)	HGML.GGGS.......G..GGGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.76|      21|      26|    1518|    1543|       4
---------------------------------------------------------------------------
 1518- 1536 (32.19/ 9.09)	...QQQQQQRQQ.HLQPPaYPGM
 1541- 1558 (25.84/ 7.47)	QQHQQQQQQQQQqHQQQQ.....
 1825- 1843 (37.73/ 7.16)	QQQQQQQQQQRR.GLN...SPGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     583.36|     157|     169|    1628|    1796|       5
---------------------------------------------------------------------------
 1424- 1599 (142.18/35.47)	TSTSAGAPDP..........ELSKLLdsfmdyYPDD........TP.......................IGS.....AAP..........SEASAISDIQKSLMLD....VETA............AFGVL..HAMNPQLIMSQQQHQQllaqqqqqqqqqqqqqqqqqqqqqqrqqhlqppaypgmLGlqqqhqqqqqqqqqqhqqqqQQQHLIRQQQRQQEHLMEAGR..........FQRP.............PPIYQARGRGPMNAVA..
 1628- 1784 (236.88/77.17)	.................QQQQKQQLL......VPENATGINAgiNN.......................IGSLLNttVAPNVsLSRTNlpADAQLSPNFAQTLMQQQLSPGRSAP.YSPQP...NQGYGPQ..FAQNAQRLSPQQQQQQ......................................NP....................QQQQLAYLQQQQQQQAGDGGRSNtpfGSGSGMQSPGMQS........SPQQWTTVAGGAAGGVAGA
 1785- 1969 (204.30/55.50)	VGGGPGGPLPagnasrsQQQHNNPLL......IAQLQNNFNA....rqyqqqqqqqqqqqrrglnspgaVGPVGN...AAAV.LQRQN.....S....F.....QAQGGSGASTPdGSSGPvglSFGGGPQspYGGGAPGNAFQQQQLQ......................................R.....................LQRQGSVPQATQHLPAGNAGGGG...GGGGNANSDFVKQelravvsvRAQQAAAAATGGGVGVGGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.77|      39|      41|     450|     488|       6
---------------------------------------------------------------------------
  450-  488 (70.88/24.22)	GDHAKLEPIINNMYSSSSNSNNSGGGGSGGGNSSATGGV
  490-  528 (71.90/24.68)	GDLDELNNGNASQQSASSNSSSSAGNGAGPGPGGGGSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.22|      15|      41|     560|     574|       7
---------------------------------------------------------------------------
  560-  574 (28.43/15.96)	SSSSNC..GDAMDQKPL
  600-  616 (22.79/11.23)	SSSVLCliTRPEDESPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.99|      25|      43|     931|     972|       8
---------------------------------------------------------------------------
  931-  955 (47.18/38.38)	PNSRASVATPVSTPRPPSGHGFSPA
  977- 1001 (46.81/13.02)	PQSNASAGAGGSSSYGFNFHSYDPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.38|      12|      19|      35|      47|       9
---------------------------------------------------------------------------
   35-   47 (18.88/13.86)	SNKhNSNINININ
   56-   67 (24.49/12.80)	SNS.NSNINNNHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.86|      20|      41|    1117|    1138|      10
---------------------------------------------------------------------------
 1117- 1138 (30.64/16.74)	GGQMGlfGPLVGRGAANAALLQ
 1161- 1180 (37.22/15.43)	GSGAG..GTGAGSGTGGPGMLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.66|      19|      19|     356|     374|      14
---------------------------------------------------------------------------
  356-  374 (34.90/20.32)	TRCATDNCSIHPVQQGEVS
  376-  394 (33.76/19.36)	TEPPLPEPSLLNGQVPEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.38|      18|      19|     728|     746|      15
---------------------------------------------------------------------------
  729-  746 (32.12/27.15)	GAPDVYVHVKA..NSRLFLN
  750-  769 (27.26/15.69)	GESDFIMSVQTllNSENDMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      13|      19|     651|     668|      16
---------------------------------------------------------------------------
  651-  668 (21.29/29.21)	RD..PFKQHLqtwvgRLWQD
  673-  687 (19.75/11.05)	HDlsTLKSHL.....RDIQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.71|      20|      20|    1225|    1244|      17
---------------------------------------------------------------------------
 1225- 1244 (32.48/21.58)	MSNEDLKRMLKIQSDPAMSR
 1248- 1266 (28.34/17.78)	LNEPDVDIAVK.RSEDKPSK
 1267- 1281 (17.89/ 8.19)	LCSEN.KMLAKLLQNP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.79|      16|     212|    1392|    1407|      18
---------------------------------------------------------------------------
 1392- 1407 (31.65/14.56)	LSQQQQQQLAYQQQQQ
 1607- 1622 (30.14/13.39)	LPNQQMRNMRQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.83|      64|    1193|      70|     154|      19
---------------------------------------------------------------------------
   70-  154 (85.41/56.23)	ACNPRsSPAaataavtisatggSVVTGPGPVPAPVAQLQHGLapSTPLQRATAASGGGAVGAGAAAAAAASNllTlqqQQQQQQL
 1287- 1350 (109.42/39.31)	APNPE.QPL.............QVKTLPDITSSSVNSVSSSL..SVPGNLISAASQSGPKAATATTAAANSR..A...RKQQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      15|      26|     889|     903|      20
---------------------------------------------------------------------------
  889-  903 (28.50/16.32)	FTASPAPGEHSFYGS
  915-  929 (29.35/17.06)	FDMDPSGGVGAWTDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.70|      19|      26|    1067|    1086|      21
---------------------------------------------------------------------------
 1067- 1086 (27.86/21.90)	QESSERlRHLLTKSQAGGLG
 1094- 1112 (33.84/21.95)	QECNED.EKLNVGSVVGPAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25131 with Med29 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLLLTSQQQQQQQQQQQQTPPLQESSERLRHLLTKSQAGGLGDEEKYFKQECNEDEKLNVGSVVGP
2) IMSQQQHQQLLAQQQQQQQQQQQQQQQQQQQQQQRQQHLQPPAYPGMLGLQQQHQQQQQQQQQQHQQQQQQQHLIRQQQRQQEHLMEAGRFQRPPPIYQARGRGPMNAVATPGGCVVLPNQQMRNMRQQQQQQKERLLQQQQKQQLLVPENATG
3) INNMYSSSSNSNNSGGGGSGGGNSSATGGVWGDLDELNNGNASQQSASSNSSSSAGNGAGPGPGGGGSGIVASKS
4) LNTTVAPNVSLSRTNLPADAQLSPNFAQTLMQQQLSPGRSAPYSPQPNQGYGPQFAQNAQRLSPQQQQQQNPQQQQLAYLQQQQQQQAGDGGRSNTPFGSGSGMQSPGMQSSPQQWTTVAGGAAGGVAGAVGGGPGGPLPAGNASRSQQQHNNPLLIAQLQNNFNARQYQQQQQQQQQQQRRGLNSPGAVGPVGNAAAVLQRQNSFQAQGGSGASTPDGSSGPVGLSFGGGPQSPYGGGAPGNAFQQQQLQRLQRQGSVPQATQHLPAGNAGGGGGGGGNANSDFVKQELRAV
5) NSQNPMLLKLLNEKSEEDDGSGAGGTGAGSGTGGPGMLNNVRQSELMRQLQKDDGGGHGHGHGMLGGGSGGGGGSGGAGGGANMSNEDLKRMLKIQSDPAMSRKRSLNEPDVDIAVKRSEDKPSKLCSENKMLAKLLQNPIKLPKAPNPEQPLQVKTLPDITSSSVNSVSSSLSVPGNLISAASQSGPKAATATTAAANSRARKQQQQLQQQQQQQQQQQQLQQQHQQQQQHQQQHQQQQQSTVQQNDI
6) PSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAGAGGSSSYGFNFHSYDPADSKPDKEQQQQQQQTANNNANNSNSSSNNNSALIG
7) QDSAVVHSPGSSANASNSGGNPGSGGGGGSI
8) QQQQQQQQLLYQQQQQHQHQQHHPHQQQQQQQHQQQQQPLHQQLNSATARIAAALQRSPAMNAVASPIPANSATSARKIRRKTDTKINLPQSQINKCNNEKRRREMENNYIEQLSEFLQLNKRGDMTSTKPDKAAILNQVVRTYRDICDKGQSRDISSTSTNNNNNSTTTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNSHKPQATST
9) SIAAAENAGLSPGDLPDHWASGTATTHGAAAATSNKHNSNINININSYNNSNSSSNSNSNINNNHNHSACNPRSSPAAATAAVTISATGGSVVTGPGPVPAPVAQLQHGLAPSTPLQRATAASGGGAVGAGA
10) TKVRMLVKDTRPATQTSSSSSSSSSNCGDAMDQKPLRQSGHQDKYEEVVLIAA
11) TTATTSNQTIAASTSTSAGAPDPELSKLLDSFMDYYPDDTPIGSAAPSEASAISDIQKS
12) VRAQQAAAAATGGGVGVGGAGVAQRGQTPQSPLQQGPMIGGSGNSTNSMGGNATPTGTGSTGNPMLNTPPDPTLGFSFETPDFFTSSATR
1045
1490
459
1655
1142
919
686
146
2
539
1411
1950
1110
1643
533
1947
1390
1036
716
353
133
591
1469
2039










Molecular Recognition Features






MoRF SequenceStartStop




1) DLKRMLKIQ
1229
1237