Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MAKMYGKGKTAIESEEQQKRRWQIELEFVQCLSNPNYLNFLAQRGYFKDPSFINYLKYLQYWKEPDYAKYLMYPMCLYFLDLLQYEHFRREIVNNQCCKFIDDQAILQWQHYTRKRIKLINSQLTQPQQQQQQQQQQQQSNGGGNILAPSEAATVAGTEATNPQQQATLQNGSSSGSGNSSTATVPASSQSNSQQQQQQQPLASREPAQAATQVSSVIQQQQQQQQQQQQQQPQQQQQQQQQQQQQMNGLAASGTMKLDLN |
Length | 261 |
Position | Middle |
Organism | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila. |
Aromaticity | 0.08 |
Grand average of hydropathy | -1.054 |
Instability index | 85.67 |
Isoelectric point | 8.59 |
Molecular weight | 30051.93 |
Publications | PubMed=17994087 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblMetazoa |
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:EnsemblMetazoa |
GO - Biological Process | anterior/posterior axis specification, embryo GO:0008595 IEA:EnsemblMetazoa regulation of transcription by RNA polymerase II GO:0006357 IEA:EnsemblMetazoa |
Binary Interactions |
Repeats | >MDP25123 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 159.42| 25| 105| 126| 150| 2 --------------------------------------------------------------------------- 126- 150 (51.36/15.67) QPQQQQQQQQQQQQSNGGGNILA...PS 162- 184 (33.84/ 7.80) NP..QQQATLQNGSSSGSGNSST...AT 185- 208 (29.98/ 6.07) VPASSQSNSQQQQQQQP....LAsrePA 232- 253 (44.24/12.47) QPQQQQQQQQQQQQQMNG...LA...AS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 76.36| 23| 29| 30| 58| 3 --------------------------------------------------------------------------- 30- 58 (34.63/39.60) QCLSNPNYLNFLAqrgYfkdPS...FINYLKY 60- 85 (41.74/27.27) QYWKEPDYAKYLM...Y...PMclyFLDLLQY --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) APSEAATVAGTE 2) ASREPAQAATQVSSVIQQQQQQ 3) QQQQQQPQQQQQ | 148 203 227 | 159 224 238 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab