<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25122

Description GH18137
SequenceMYADKRGLEKPGSALSAAAAAAAAAAAAAAAAVAVTHLATPTHAHALQQQQQQQQQQQQQHHHVLQLQHQQQQQQQQQQQQQQQQQQHLQHQQLHMQQHMHTHHNFQQQQQQQQQHEPATLSQQQHLQQQQQQQQQQQQQAAQQQQQASQQQQQQAAGMFTRFDANKSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNALHQHHQTATPNIGFSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYDIIDKQDHATIQAELNRNVPPQPGGSSSSSVGVGIGVGDSTSSNGTGGASSLEGEHRMFLCRMNVSRNARRQMRFGDQKVVLVQGHYLSFLPLCSRNEPVFLATCTPIAMPETRECVVQGATNVFTTIHSMDMKIAHIDKNGEFHLGYEKASLQGTSWYNLIHSENLREAQSKHRLITQSEQDRSCILLVRMQCSSGDYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREASIMLANSWLYHYYTVQSKIQFGMPLDSAMRVPPGSSSSSSSYFGTHQQSHGGAGVASLGMSSGAVGMSGVFAHHHHHHHTTAAATYHHHHSHMGAAYGGVYHAEGALELKEDQPLYVGGFQSGGGLEPVDYSQVNGTPTGTGSQKATQSATSPPPKKRARNKLEPLYLHAERSPAATTITPEPDCYALHPGGAYATAAPGSSDASASVIYATIVPTRPRLLNKTLPPDPADFIEQWNPSPPWSESAQKASLDSFGSSHELSPCITTTPPTPTSATPHHGGVSAQAIGPAFSFEWMSDPLVPVAYQQWPPATGDHHQHLSQHLAAAQQQQHQQHQLQHQQHPQHQQQHHHQQHPQLTLHGVHVARVELAAESMAGTGRADATEPVEDRG
Length906
PositionTail
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.662
Instability index61.82
Isoelectric point6.89
Molecular weight99752.55
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:EnsemblMetazoa
protein-containing complex	GO:0032991	IEA:EnsemblMetazoa

GO - Biological Function
DNA-binding transcription factor activity	GO:0003700	IEA:EnsemblMetazoa
protein heterodimerization activity	GO:0046982	IEA:EnsemblMetazoa
sequence-specific DNA binding	GO:0043565	IEA:EnsemblMetazoa

GO - Biological Process
branch fusion, open tracheal system	GO:0035147	IEA:EnsemblMetazoa
epithelial cell migration, open tracheal system	GO:0007427	IEA:EnsemblMetazoa
imaginal disc-derived leg joint morphogenesis	GO:0016348	IEA:EnsemblMetazoa
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25122
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     260.09|      25|      26|      48|      72|       1
---------------------------------------------------------------------------
   37-   59 (33.53/ 6.91)	...HLATPTHAH.......AlQQQQQQQQQQQQ
   60-   85 (50.06/13.72)	QHHHVLQLQHQQ.......QqQQQQQQQQQQQQ
   86-  113 (40.20/ 9.66)	QQH....LQHQQlhmqqhmH.THHNFQQQQQQQ
  114-  139 (49.81/13.62)	QQHEPATLSQQQ.......HlQQQQQQQQQQQQ
  823-  848 (42.38/10.55)	QQWPPATGDHHQ.......HlSQHLAAAQQQQH
  849-  868 (44.11/11.27)	QQHQL...QHQQ.......H.PQH..QQQHHHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.32|      19|      27|     552|     574|       2
---------------------------------------------------------------------------
  552-  570 (37.85/11.24)	GSSSSS...SSYFGTHQQSHGG
  577-  598 (32.47/12.42)	GMSSGAvgmSGVFAHHHHHHHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.42|      17|      98|     645|     661|       3
---------------------------------------------------------------------------
  635-  651 (29.75/14.88)	VGGFQSGGGLEPVDYSQ
  652-  668 (28.67/14.07)	VNGTPTGTGSQKATQSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.29|      37|      98|     692|     728|       4
---------------------------------------------------------------------------
  692-  728 (69.19/41.06)	PAATTITPEPDCYALHPGGAYATA.APG.....SSDASASVIY
  780-  822 (62.11/36.01)	PCITTTPPTPTSATPHHGGVSAQAiGPAfsfewMSDPLVPVAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25122 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPVDYSQVNGTPTGTGSQKATQSATSPPPKKRARNKLEPLYLHAERSPA
2) IQAELNRNVPPQPGGSSSSSVGVGIGVGDS
3) MYADKRGLEKPGSALSAAAAAAAAAAAAAAAAVAVTHLATPTHAHALQQQQQQQQQQQQQHHHVLQLQHQQQQQQQQQQQQQQQQQQHLQHQQLHMQQHMHTHHNFQQQQQQQQQHEPATLSQQQHLQQQQQQQQQQQQQAAQQQQQASQQQQQQAAGMFTRFDANKSTKGASKMRRDL
4) PRLLNKTLPPDPADFIEQWNPSPPWSESAQKASLDSFGSSHELSPCITTTPPTPTSATPHHGGVSAQAIG
5) VAYQQWPPATGDHHQHLSQHLAAAQQQQHQQHQLQHQQHPQHQQQHHHQQHPQLTLHGVHVARVELAAESMAGTGRADATEPVEDRG
645
297
1
736
820
693
326
179
805
906










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAAAAAAAAAV
2) EPLYL
3) MYADKRGLEK
20
682
1
33
686
10