<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25118

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDWQSQGFRQNVISKIHDMLPQNAEPSKNASMMENHIFRKSRTRDEYLGLVAKLFMHYKDTQRKSQAQQQQQQQLQQQQQQQPPPPNAEMGQQNLMQDPLNALQNLASQGNRNPQLMPMGGGSGAPGPNQMAGPGGPGTASNLLQSLNQQRPGQQQMQPMPSIRGQLPMGGGGAGGQQQMVQVQQQMAGGNGPGVAGGMQLNAMGPAVAQAQGQIVGNAGGISNQMVGPGPNSGPAGGAAGGMPNQMSPMVMGIGNPMMRLNQGMQGMPTNMQQQHNVVGGPSGQQQVGGPGVLPPNAVQQGGAMNPMGGMNVNMPPNMQQKANMAMGQAGQMFAGNRGGVVGGQQQPQQPFMRSSPSPADAQQLQQQQQLQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMMQNSQRSIRQQSPSASINTPGQVTGNSPFNPQDEALYREKYKQLTKYIEPLKRMLGKISNDGTNVEKMTKMSKLLEILCNPTQRVQLDTLLKCEKALEKMDLVSYSGQQFGKSSNPLLEVINTTLQSPLANHTLHRTFRPSLELLFGTDICAPVPAKKPRLGDKTSPFEQDVPHVLQGEIARLDTKFKVKLDTTAQNNNKTIKLICCLDDKRLPSVPPVSVSVPDEYPWQSPDCSLTEQEYSATPFLQTVQQALIARMSKLPKNYSLSHLLDTWEMAVRQACSPQSKPRPICELSTLLGV
Length742
PositionTail
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.03
Grand average of hydropathy-0.758
Instability index68.71
Isoelectric point9.36
Molecular weight80858.99
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25118
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.07|      17|      17|     374|     390|       1
---------------------------------------------------------------------------
  373-  389 (34.35/ 7.32)	LQQLQQQQQQQQQQQQQ
  390-  406 (34.72/ 7.49)	QQQQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     277.17|      44|      45|     158|     201|       2
---------------------------------------------------------------------------
  158-  201 (93.42/28.80)	QMQPM......PSI...RGQLP........MGG............GGAGGQQQMVQVQQQ..MAGGN.G..P..G.VAGGM
  202-  245 (45.77/ 9.39)	QLNAM.....gPAVaqaQGQI.........VGN............AG.GISNQMVG.......PGPNsG..PagG.AAGGM
  248-  305 (40.79/ 7.36)	QMSPMvmgignPMM...RLNQG........MQGmptnmqqqhnvvGGPSGQQQ..........VGGP.GvlPpnA.VQQGG
  306-  347 (50.40/11.28)	AMNPM......GGM...NVNMPpnmqqkanMAM............GQAG.........Q...MFAGN.R..G..G.VVGGQ
  426-  467 (46.79/ 9.81)	QMIPS......PAL......VP........QSS............PQMMMQNSQRSIRQQspSASIN.T..P..GqVTG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.45|      19|     295|      57|      82|       3
---------------------------------------------------------------------------
   57-   82 (29.68/22.21)	FMhykdtqrKSQAQQQQQQQLQQQQQ
  354-  372 (36.77/13.83)	FM.......RSSPSPADAQQLQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.42|      18|      45|      86|     103|       5
---------------------------------------------------------------------------
   86-  103 (36.88/11.98)	PPPNAEMGQQNLMQDPLN
  105-  122 (28.54/ 7.67)	LQNLASQGNRNPQLMPMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.69|      44|      77|     609|     656|      13
---------------------------------------------------------------------------
  609-  656 (70.48/56.70)	PFEQDVPHVLQGEIARLDTKFKVK..LDTTaqnnNKTIKLICCLDDKRLP
  687-  732 (73.22/48.93)	PFLQTVQQALIARMSKLPKNYSLShlLDTW....EMAVRQACSPQSKPRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25118 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QGFRQNVISKIHDMLPQNAEPSKNASMMENHIFRKSRT
2) YKDTQRKSQAQQQQQQQLQQQQQQQPPPPNAEMGQQNLMQDPLNALQNLASQGNRNPQLMPMGGGSGAPGPNQMAGPGGPGTASNLLQSLNQQRPGQQQMQPMPSIRGQLPMGGGGAGGQQQMVQVQQQMAGGNGPGVAGGMQLNAMGPAVAQAQGQIVGNAGGISNQMVGPGPNSGPAGGAAGGMPNQMSPMVMGIGNPMMRLNQGMQGMPTNMQQQHNVVGGPSGQQQVGGPGVLPPNAVQQGGAMNPMGGMNVNMPPNMQQKANMAMGQAGQMFAGNRGGVVGGQQQPQQPFMRSSPSPADAQQLQQQQQLQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMMQNSQRSIRQQSPSASINTPGQVTGNSPFNPQDEALYREKY
8
60
45
483










Molecular Recognition Features






MoRF SequenceStartStop




NANANA