<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25116

Description GH21297
SequenceMPICKSSPATATSKKTATDISADHVTEAAQVKRTREQAYFNSYDFDAIEVLPYDEDNDEAAVAHSRASSGRYSAANNSSSNNSSSSSHNNKDSAGLTKFGYLQRLGAFFGQKTVATDGVTAAATTAVAATANGVGDEQQQQQQHVGSASAAESNDNFLLPRAMLKYAPYQSVGGNVTTSMPFTAAPHSMNGLETSGQTGSSCVATANEIKPVVASGALVVVAPPPRHKKRSTASNANSTHTTDSGLGATIATTSKTAAAAAAAAAAQATTPTAAAAAAAATATSAAAAAVRAGSGSHYSTDKSGSSGYYSSHVCSTYSLDEHIYCEPVIDILETSDKDKSKATAARQRPQLQLPTKVAGNEAAAAAAATTVSSTISQHLDMQHVADKAGADQANAAPEIGRQPTNGSQKKLQQQQQQQQQQQQLQQQQQLQLQPHYSDKLRILETSIENLDRHLKTFPCLYAPQQTVSFMQQQEIARPAEGIQLDIGEKLRAYNQLPTIMEGFAATQRRQQQQQQQQQQQQQMEQVVDDSLLDIDLDAFLLQPKSKQQQLRTAGIDNPSFLSDEQLEENNYKCAKYINSCPEDAYRVDTDASSNMVPAGIISPNTSYAKRYEDQLHFQSTRELLEDVRDKIRLLSPTPTTDIPQELDGMIQTLKHELESYLQRMNQHSELELRQLCSGLGRQQHVVRLQNALERRRSFAGDLQLNAYESVRDGGVLISTSRRPSSLRAQIMSIRCASDPNFKMKRKSITEIFPVAECYIETTTTVSRSATPTLTITPSLTPTPSPPLELNTTTMVTQMQRNLNFHKPVLNASGSRSRLGNGVDKIDSAAEWHRKKPSIWEMYYGTNRLHQSLLGKQRHGGELVISSAHPTLSYPSSRPESDFTLDLPRAEQLRLKMEKEKKFRQRCRFITTFLSLVFFLLTVMVVSLVLTRGKRMFGSMI
Length940
PositionTail
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.546
Instability index54.96
Isoelectric point8.30
Molecular weight102648.49
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW

GO - Biological Function
GO - Biological Process
copper ion homeostasis	GO:0055070	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25116
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     391.99|      92|     376|     136|     230|       1
---------------------------------------------------------------------------
  136-  230 (148.51/71.09)	DEQQQQQQHVGSA.................SAAESN.DNFLL.PRAMLKYAPYQSVGGNvttSMPFT..AAPHSMNGLETSGQTGSSCVATANEIKPVVASGALV...VVAPPPRHKKR
  415-  516 (118.21/51.49)	QQQQQQQQQLQQQqqlqlqphysdklrileTSIENL.DRHLK.TFPCL.YAPQQTVS.....FMQQQeiARP..AEGIQL..DIGEKLRA.YNQL.PTIMEGFAA...TQRRQQQQQQQ
  517-  610 (125.26/54.91)	QQQQQQMEQVVDD.................SLLDIDlDAFLLqPKS..KQQQLRTAGID...NPSFL..SDEQLEENNYKCAKYINSCPEDAYRVDT.DASSNMVpagIISPNTSYAKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.29|      15|      15|     251|     265|       2
---------------------------------------------------------------------------
  259-  275 (22.23/10.00)	AAAAAAAaqATTPTAAA
  276-  286 (18.75/ 7.31)	AAAAATA......TSAA
  362-  374 (17.32/ 6.20)	AAAAAAA..TTVSST..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.19|      13|     136|     105|     122|       3
---------------------------------------------------------------------------
  105-  122 (17.30/20.08)	LGAffgqkTVATDGVTAA
  246-  258 (22.90/11.55)	LGA.....TIATTSKTAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.14|      51|     136|     635|     696|       4
---------------------------------------------------------------------------
  637-  696 (78.25/62.28)	TPTTDIPQELD..GMIQTLKHELesylqrmNQHSE.LELRQLCSGLGrqQHVVRLQNALERRR
  780-  833 (83.88/42.43)	TPTPSPPLELNttTMVTQMQRNL.......NFHKPvLNASGSRSRLG..NGVDKIDSAAEWHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.56|      18|      50|     338|     355|       5
---------------------------------------------------------------------------
  338-  355 (31.26/15.51)	DKSKATAARQRPQL.QLPT
  386-  404 (27.30/12.68)	DKAGADQANAAPEIgRQPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.35|      23|     223|      63|      85|       6
---------------------------------------------------------------------------
   63-   85 (41.06/25.18)	AHSRASSG.RYSAANNSSSNNSSS
  288-  311 (38.29/22.98)	AAVRAGSGsHYSTDKSGSSGYYSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.48|      32|     143|     711|     745|       7
---------------------------------------------------------------------------
  711-  745 (52.55/40.79)	RDGGVLISTSRRPSslrAQIMSIRCASDPNFKMKR
  857-  888 (57.93/37.06)	RHGGELVISSAHPT...LSYPSSRPESDFTLDLPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25116 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEDNDEAAVAHSRASSGRYSAANNSSSNNSSSSSHNNKDS
2) ISQHLDMQHVADKAGADQANAAPEIGRQPTNGSQKKLQQQQQQQQQQQQLQQQQQLQ
3) SGALVVVAPPPRHKKRSTASNANSTHTTDSGLGAT
4) TAVAATANGVGDEQQQQQQHVGSASAAESN
54
375
215
125
93
431
249
154










Molecular Recognition Features






MoRF SequenceStartStop




NANANA