<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25103

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGSHAKNNSGGYGSHTVVAIPIPSIEEKNKQMQQETMMEKLRAKYRNKPKSYEDIKKSVRMYFIEKHYPLDPLCKAALQSALDKLQHYIKVSSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDASGNLNDVKVHHECKIEQQSNSSASSRELLNCLKAGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDISNLYQQQLQKQQQLRGNSDSYYIMNNSSLGLVMERRGGHPMKLTYFCPPLQLIEKKVKAEKLATATASGTASRDFSIEQVMKSPNGLSATLNLEGSSANKLQILPIVSFTSESGLPLEQPSYAPLTQNNSMLMPATYVLRLNKPMPVCIESLRALALPGLGSLGVSGEGTTVMNLIVQTASRQLIKSTQKGLYVNLPKETHCYFFTDNRRLQGTLISTLPFTEPAQVPRIIAFLKKQALFCTLLSSCVREQQKQYNDMDSTVILEVTAVSLSQITVELQHPYEESLATVDFLLEDGQATCTIYCLSNDYEALSQKLTRTVRQVLSIPMVIYKLLKCWDEEHQQKLHGAIVPGAGSGAGSGTAGGFSSTGGGGGMHGTSNFGQFAMETGGGEGSSGVGGGFNSVGNLKMDSKVRSLADAFAASTSAAAAIAGLMNLKRETDPQLGEGNIPILSSSSSSASASKASENEIADKYKNIWKDKTPNLKHCVSITPIAGDGKAPPQQQVDVQRTGGIEIIPLNAPGSVVATPSAGSPATTITITPITGVGKELSKDAKKSVSSGSATKRPHESSSSSSSSSNSNSNSSSSSSSSNSSSDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAGGGISDPVAGSGVVRKFSSPSASSSSSPKPGGMGSGAGGGAALGLMSGQPARPSPKHSPVYSSPKHNSSSNTASNSPKSPFGTLSPKHGSSGKPSMSTLKSATAATSLSLSPKAEKSLSASGGGGGSNSVHPLPLASSGSGANPSMMRPVPPLASTISGITNQLSTSFKKDKSNASSCAPGAPPGVVAVPVAALKNSQQQQQLKSSVASLSHLAAGGNLSSYVAPTVAALELNALRKGLSGAGVGPGMGAAAGAVGAVSLMTSTAASTATIQTTTTASLSSTTTAVDSSDTAATTTAAAAAAVEAGVGLGVGAAIAPVAPIATTQIATQQQQAAGPHSSDNCSPSSASNSNSIISGAASGLSTGYMVKPSSQEGLKLTINKTGSGKRESKGGTTASSSSTSSSASSSTGVKKQHTGLKPGVNSGPASKKAPSAAAGSSKHLFQKANSSGNLSSKLSGSSTSTSGGGLPLTKSNSTNSFQEQSVPRRRPSMGNSSGGGVQRKAQLTPSASASGSGAGVGIGSGMGAGRMSPAAMSGSMSQPPPRFDHRTDMMTILQYASPTMAASMEGFIKGLHNKFQIPKLSQRQSGNSSSSSTVGHSLTNTDQVQSESAAASSSMEQQQMSALASSLTGTMPSGSSGVLKLSPVASSGSAANANDLLLSLNSSGSIGDGIDEELLASLAGE
Length1515
PositionMiddle
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.04
Grand average of hydropathy-0.315
Instability index53.30
Isoelectric point9.42
Molecular weight155906.32
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25103
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.99|      25|      28|    1274|    1299|       1
---------------------------------------------------------------------------
 1259- 1283 (32.26/ 7.98)	ASKK.APSAAAGSSKHL.FQKANSSGN
 1284- 1310 (28.73/ 8.85)	LSSKlSGSSTSTSGGGLpLTKSNSTNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     739.43|     112|     113|     687|     798|       2
---------------------------------------------------------------------------
  630-  713 (88.95/24.92)	...............................................................ASTSAAAAIAGL.MNLKRETD.PQLGE...........G.NI...PILSSSSSSASAS..........KASENEI......ADKYK.......niwkD..K.T...PN...LKHCV.SITPIAGDGK.....AP..PQQQV
  714-  826 (147.21/46.54)	DVQRT...G..G....IEIIP.LNAPGSV..VATPS..AGSP.....................ATTITITPITGVGKELSKDAK.KSVSS...........G.SATKRPHESSSSSSSSSN..........SNSNSSS......SSSSS.......nsssDtqK.E...KK...RKKKR.DDSPM..........GP..PEKIY
  827-  951 (124.96/38.28)	SRQNSpagG..G....IS.DP.VAGSGVVrkFSSPS..ASSS.....................SSP...KP.GGMGSGAGGGAA.LGLMS...........GqPARPSPKHSPVYSSPKHN..........SSSNTAS......NSPKSpfgtlspkhgsS..G.K...PSmstLKSAT.AATSLSLSPK.....A....EKSL
  952- 1065 (108.64/32.23)	SASGG...G..GgsnsVHPLP.LASSGS...GANPS..MMRP.....................VPPLAST.ISGITNQLSTSFK.K........................DKSNASSCAPG..........APPGVVA......VPVAA.......lknsQ..Q.Q...QQ...LKSSVaSLSHLAAGGNlssyvAPtvAALEL
 1066- 1165 (84.68/23.34)	NALRK...GlsG....AGVGPgMGAAAGA..VGAVSlmTSTA.....................ASTATIQ..TTTTASLSSTTT.AVDSS...........D.TAATTTAAAAAAVEAGVG..........LGVGAA...........................iA...P...........VAPIATTQI.....AT..QQQQ.
 1166- 1258 (93.22/26.51)	....A...A..G........P.HSSDN.....CSPS..SASN.....................SNSI....ISGAASGLSTGYM.VKPSSqeglkltinktG.SG.KRESKGGTTASSSST..........SSSASSS......TGVKK...........Q..H.T....G...LKPGV.NSGP....................
 1342- 1484 (91.77/25.97)	SASGS...G.aG....VGIG...SGMGAG..RMSPA..AMSGsmsqppprfdhrtdmmtilqyASPTMAASMEGFIKGLHNKFQiPKLSQ................RQSGNSSSSSTVGHSltntdqvqseSAAASSSmeqqqmSALAS...........S..L.TgtmPS...GSSGVlKLSPVASSGS.....A........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.37|      17|      17|     563|     579|       3
---------------------------------------------------------------------------
  562-  578 (32.28/16.40)	AGSG.AGSGTAGGFS.STG
  579-  597 (24.15/ 9.84)	GGGGmHGTSNFGQFAmETG
  598-  613 (30.94/15.32)	GGEG.S.SGVGGGFN.SVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      19|      26|     453|     471|       4
---------------------------------------------------------------------------
  453-  471 (33.95/23.94)	LSSCVREQQKQYNDMDSTV
  480-  498 (31.90/22.04)	LSQITVELQHPYEESLATV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.93|      16|      17|      54|      69|       6
---------------------------------------------------------------------------
   54-   69 (27.97/22.47)	EDIKKSVRMYFIEK..HY
   72-   89 (22.96/16.94)	DPLCKAALQSALDKlqHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.18|      18|      71|     293|     310|       7
---------------------------------------------------------------------------
  293-  310 (28.93/11.80)	PNGLSATLNLEGSSANKL
  317-  334 (31.25/13.29)	SFTSESGLPLEQPSYAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25103 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CVSITPIAGDGKAPPQQQVDVQRTGGIEIIPLNAPGSVVATPSAGSPATTITITPITGVGKELSKDAKKSVSSGSATKRPHESSSSSSSSSNSNSNSSSSSSSSNSSSDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAGGGISDPVAGSGVVRKFSSPSASSSSSPKPGGMGSGAGGGAALGLMSGQPARPSPKHSPVYSSPKHNSSSNTASNSPKSPFGTLSPKHGSSGKPSMSTLKSATAATSLSLSPKAEKSLSASGGGGGSNSVHPLPLASSGSGANPSMMRPVPPLASTISG
2) NKFQIPKLSQRQSGNSSSSSTVGHSLTNTDQVQSESAAASSSMEQQQMSALASSLTG
3) NLKRETDPQLGEGNIPILSSSSSSASASKAS
4) PSSQEGLKLTINKTGSGKRESKGGTTASSSSTSSSASSSTGVKKQHTGLKPGVNSGPASKKAPSAAAGSSKHLFQKANSSGNLSSKLSGSSTSTSGGGLPLTKSNSTNSFQEQSVPRRRPSMGNSSGGGVQRKAQLTPSASASGSGAGVGIGSGMGAGRMSPAAMSGSMSQPPPRFDHRTDMMTILQYA
695
1407
643
1202
992
1463
673
1390










Molecular Recognition Features






MoRF SequenceStartStop




1) EKIYSRQ
2) TAATSL
823
936
829
941