<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25102

Description GH14662
SequenceMLSLLQEKRPLKRTRLGPPDIYPQDAKQREDELTPSNVKHGFITTPPLSDEFGTAHNSNVNASKVSAFFSGVLAKKEELMTLQDTVRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQSHEKNGMQSNGSSSSSSTTSSTSSSNSNGSANNNSSSSNNTNSGSNNNSSVGNTSTPNVIPVPSMSSPLPPIHSPANGQPGAVGSGAVGGAVAGAAAPPGTALATLSGSASGGAAGASAGAVPPGSSISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMANLVAKKLAQLLNSAVEQQQQQQQQQALIKSQAMELDAPDEQLHHHQQQHQQQQSVDPYEQALHDYMNCPHHRDIVLYLSTILQVITIECPTALVWSGIAAHRAPSSLVGSPLDHLPLAPSVLPMASRCPRTNQELRRQLRAAEADIVLRTQHAEQRWFASKWLSAGKNHYTNVLATLDHLDTHCFERMDQCNSIDTLYAHIFPPQSAQLLRRSEDDQQQQPQRAVYEPKQDADTVRILCEWAVSSQRWGEHRAIVVAILLDKRQIDVTSTPADLCGDKEDKDSLASGAGIIDGLPVFQHVLMHFLDHDAPVLDEHNSSAQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESMLVHKPAAKSSPPPPAPPPPNSSSTAHAFDDDGFGSGIGIDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGGPGDGDGGGVDTPASGVSISRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTAKCQHMAYFDQHVVTAQCAANVLEQLNGFALGSNNYLPVQEHVAFLFDLMELALNIYSLLELCDHLLKELPEVEHQLQQKKSNMVRGYTTSLALYIVSILRRYHSCLLLSPEQTVSVFEGLCRTIRHVSNPSECSSAERCILAYLSDLHESCILLQGKEQAAEYYQQLNCIKRFKDIFNTPEQLSMAPQGYNTQLLQELFVAPRRGGKLESHWLRQLHESSANVYSFVSNAVIAVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGGQVDIGQSKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSGASGGELSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAAGSDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAAQKTPLVASGLGSSSSGSAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSLGSEQESLQQTTSSSLVGNEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRSMIVRILEHLDQWTLRISWLDLQLMYRQSLSNNTSLSNNTELNVWLDTVARAAIDVFHMEEVTLPGALKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVPKSDCNSSGSGDEREKSNSCHSSNSYGGNGSLTARNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYSQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFDAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDSQSERDEHKKLYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDTKGNKICDMDKKQLRISDKQRISVWDILEGHKNPAPFSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMMKADTPSSVDQSPSAVVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQQPNAQQQQQMQQQQQHMQQQMQPNQMGQMPMNMQMNMQQFGPNAMMQQQNALMQQQQQQQQQQQQVQMQQMAPNQMQQQLSVGGNGQPNAQMNFMQGPGPGGPQGMPGQQQQQQQQWHNAPQQQQQPQQYHNQYPHQQNMQMNRIERPPLNTNSKQALSQMLRQRQPGSFQQQQQQPPGGFNPMQQQQQQAQQQQQGSQQQQMNAQQLRQQQQMNAQQNPQAAAAFNAMQQQPNVQQQQQMNPNQQMQQQQQQFMRGSLRGMAPNQLGGMNMVGQGMPQNPILQQQQMTQGMVGMVNPNANQMMQGGGAGGNGGVGVGVGVGVGAGGNNPNMGMGGMPQQGMIQQQQQVQFQNFQNQQYQQQQQQQGMQQQGGGGGGGGVGVGMAPNQQQQQQAGLMSNFNPQMQQAQRNNPDFMAAAVVAQQQQQQQQQQRGVPGGMMAGNRGQYMNQAPNVTMTNMMGPGPGGVGVGQVPPYARQQSAGGGKPGVIPTQQQFQQQQQQLRHQQMMQMQSMAGGGMGGGPQAGGGAVAGGGGGMVQQQQSMNQQQTPNLVAQLQRQMPNQPNMMGQQQQYPHQPPPY
Length2601
PositionKinase
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.570
Instability index55.56
Isoelectric point7.37
Molecular weight287302.30
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25102
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     623.25|      46|      46|    2024|    2069|       1
---------------------------------------------------------------------------
 2024- 2069 (106.87/38.13)	QP.NA..QQQQ.QMQQQQQ.H.....MQ.QQ...........MQ.....PNQM.........GQMPM.......NMQM.N.MQQF..GP......NAMM
 2070- 2125 (65.87/20.51)	QQqNAlmQQQQ.QQQQQQQ.Q.....VQmQQ...........MA.....PNQMqqqlsvggnGQ.P........NAQM.NfMQGP..GP......G..G
 2129- 2174 (66.88/20.95)	MP.GQ..QQQQ.Q.QQWHN.A.....PQ.QQ...........QQ.....PQQY........hNQYPH.....qqNMQM.N.RIER..PP........LN
 2177- 2208 (43.96/11.10)	SK.QA..LSQM.LRQRQPG.S.....FQ.QQ...........QQ.....QPPG.........G.....................F..NP........MQ
 2209- 2253 (59.80/17.91)	Q.......QQQ.QAQQQQQgS.....QQ.QQ...........MN.....AQQL.........RQ..........QQQM.N.AQQ...NPqaaaafNAMQ
 2255- 2319 (58.51/17.35)	QP.NV..QQQQ.QMNPNQQ.......MQ.QQqqqfmrgslrgMA.....PNQL.........GGMNMvgqgmpqNPIL.Q.QQQMtqGM......VGMV
 2320- 2355 (48.07/12.87)	NP.NA..NQ.................MM.QG...........GG.....AGGN.........GGVGV.......GVGV.G.VGAG..GN......NPNM
 2376- 2413 (54.75/15.74)	...NF..QNQQyQQQQQQQ.G.....MQ.QQ...........GG.....GGGG.........GGVGV.......GMAP.N.QQQ...............
 2445- 2490 (60.97/18.41)	Q........QQ.QQQQQQQ.RgvpggMM.AG...........NR.....GQYM.........NQAP........NVTMtN.MMGP..GP......GGVG
 2511- 2552 (57.56/16.94)	IP.TQ..QQFQ.QQQQQLR.H......Q.QM...........MQmqsmaGGGM.........GGGP.................QA..GG......GAVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.27|      20|      22|     205|     224|       3
---------------------------------------------------------------------------
  205-  224 (36.44/20.58)	SHEKNGMQSNGSSSSSSTTS
  228-  247 (35.83/20.10)	SSNSNGSANNNSSSSNNTNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.65|      20|      22|     291|     310|       4
---------------------------------------------------------------------------
  291-  310 (34.40/18.52)	AVGGAVAGAAA..PPGTALATL
  314-  335 (31.25/16.05)	ASGGAAGASAGavPPGSSISGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.12|      21|      21|     422|     442|       5
---------------------------------------------------------------------------
  422-  442 (34.48/15.27)	KKLAQLLNSAVEQQQQQQQQQ
  446-  466 (38.64/18.07)	KSQAMELDAPDEQLHHHQQQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.03|      20|      20|     984|    1003|       6
---------------------------------------------------------------------------
  984- 1003 (34.86/23.85)	LEQLNGFALGSNNYLPVQEH
 1007- 1026 (34.17/23.20)	LFDLMELALNIYSLLELCDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      21|      27|    1727|    1748|       7
---------------------------------------------------------------------------
 1727- 1748 (30.93/25.28)	LDTIGGIDEPQAREEILDAlQL
 1757- 1777 (36.04/24.35)	FDAIQKNSTPTTDWAILLA.QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.84|      12|      15|    1994|    2005|       9
---------------------------------------------------------------------------
 1994- 2005 (21.68/ 9.11)	TRKRKPKNPKTP
 2010- 2021 (22.16/ 9.49)	TQQQQPQLAPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.34|      22|      23|    1431|    1453|      10
---------------------------------------------------------------------------
 1431- 1453 (30.73/19.40)	SQILGTSDlQLGSLGSEQESLQQ
 1456- 1477 (31.61/15.63)	SSSLVGNE.QISLLEFAQAVLKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.38|      11|      21|    1359|    1369|      12
---------------------------------------------------------------------------
 1359- 1369 (18.76/10.93)	AHKTIPIAAVL
 1383- 1393 (18.62/10.79)	AQKTPLVASGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25102 with Med12 domain of Kingdom Metazoa
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