<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25101

Description GH16236
SequenceMAPTPLPLEQMPAANAGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELMVLAELLPRKTDMERKVEIYAYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDAITPAEKKQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVALTVMGDSPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNVNVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITDEMQDCLNGDRSKLPMLLSELRYWITHRRCEKTLQHLPATATETLPFLMLPEQELLQAGRHKIYVKLHRHPNIILVVQLKEKSAMPNEMEYTFHLGFVVYQKDENDVVDDSAKQLVSIVAQTPSDIPKFYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDILAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFLNLAQALSKHRIPHSGLQVEANATSLVLKILALPKPGSSQPAATAAAAATGEPGKPTPATAPNSSTALPKIESHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSTHQKEQGSRRTVYLTYEQANHDFSKTVEDLLNDWSKIVYLYTLVHDFAEQLGNKRLTLGDMLVVKSFNYVNLLLGYGPKKEVTCSIYWSVQSHGFRLTFVGGISAVNAHSMMRDQLAQHLNQQHSLTTIAHILHETYNPMSSIAKLPVIPLLGIPRTQVPVLSFCMLPQSPCLMRLAYQAVYCLELRFRANRLVSIRDGASSRFDRNVIEEFTPIQGLKAFLSKYADESAVYRGRAPHEDDNPLSPMGLEDNFGGPSSVTGVSAGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGAGGGAQSHANFNLTSPPAPHMPHPSPGGLMPSSPLNPLPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHRSTGGANAGVGGAADRSVTRGTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVADMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVMLNQMHMQSLHLKVTQLPPTPDKNTFPLILDDLLVIEQYFDTRVAAPPYRPNALHSICRLLNLPGHVLKDFVQIMRLELKPELGGDQLKWTVQMCMRVPPSAMPIVPIGNACVVLGRMKILFFLHITRIPYNGKDSLVLPIVHDIATNLTQVAEKREQVQSPIMTAASTLLRRFADFGVQQNQCSLFPAITELLTNLQPTTDLPPPPPNQSIGPPVGVGVGVGVGVGVGVGVVGASPNAMMPMQQLQPQVGGHGPQLGPNLSVPQ
Length1546
PositionTail
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.199
Instability index51.03
Isoelectric point8.46
Molecular weight171151.23
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25101
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     310.90|      47|      54|    1104|    1150|       1
---------------------------------------------------------------------------
 1003- 1050 (39.80/12.83)	.......G...RAP.HEDDNP.L....SPMGLEDnfGGPSSVTgVSAGGSSPFLSagmrgpQSP
 1055- 1099 (67.62/27.06)	LRFPAPHT.....P.PSSSNPhT..PaSPHPSAG..GGGAGGG.AQSHAN..FNL......TSP
 1104- 1150 (93.39/40.23)	MPHPSPGG...LMP.SSPLNP.L..P.SPHMVHS..PGPNTLY.MQSHQDSPFTA......MSP
 1155- 1196 (64.06/25.23)	WP.GSPS.....MPrPSP.RP.G..Q.SPEHRST..GGANA.G.VGGAADRSVT.......RGT
 1197- 1235 (46.04/16.02)	LNRPWAGAvptLLT.HEALET.LcrP.SPH........PN........KDINVAD......MSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.55|      21|     130|     127|     155|       3
---------------------------------------------------------------------------
  127-  153 (28.58/29.89)	LVRARLpnFHIPAAVevltTGTYNRLP
  260-  280 (35.98/17.70)	LIQARL..VENPNAL....SEVYNCLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.50|      87|     507|     290|     426|       5
---------------------------------------------------------------------------
  313-  426 (119.93/166.02)	YVPGVKLTVS.YWrDLKSElGYRLTVQSDPSEI.GRPLAvvhvpslgakeSAEVADRAVRSEHLSMERLIVHTVY..IRSVSRLSDLklefqaflkdvdfNLQGTPAIlTVPVLSPCL
  845-  935 (144.57/86.76)	YGPKKEVTCSiYW.SVQSH.GFRLTFVGGISAVnAHSMM...........RDQLAQHLNQQHSLTTIAHILHETYnpMSSIAKLPVI.............PLLGIPRT.QVPVLSFCM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.78|      30|     185|     468|     507|       6
---------------------------------------------------------------------------
  478-  507 (57.78/48.78)	YWITHRRCEKTLQHLPATATE.TLPFLMLPE
  637-  660 (42.29/17.99)	YFIPE......LAHVVAMCDE.KIPFLNLAQ
  664-  690 (32.71/13.82)	...KHRIPHSGLQ.VEANATSlVLKILALPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     273.43|      62|     185|    1240|    1302|       7
---------------------------------------------------------------------------
 1240- 1302 (104.85/74.15)	LGCVYMRRQLHRNIQSeETLTALNSTEPGVVL.....FKVDGLQCQVMLNQMHMQSLHLKVTQLP.PTP
 1364- 1415 (85.24/54.98)	LGG....DQLKWTVQ..MCMRVPPSAMPIVPI.........GNAC.VVLGRMKIL.FFLHITRIPyNGK
 1430- 1488 (83.34/53.57)	LTQVAEKRE...QVQS.PIMTA.....ASTLLrrfadFGVQQNQCSLFPAITELLTNLQPTTDLP.PPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.48|      14|      15|     691|     705|      14
---------------------------------------------------------------------------
  691-  705 (20.74/13.13)	PGSSQPaATAAAAAT
  708-  721 (27.74/13.98)	PGKPTP.ATAPNSST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25101 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YRGRAPHEDDNPLSPMGLEDNFGGPSSVTGVSAGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGAGGGAQSHANFNLTSPPAPHMPHPSPGGLMPSSPLNPLPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHRSTGGANAGVGGAADRSVTRGTLNRPWAGAV
1001
1205










Molecular Recognition Features






MoRF SequenceStartStop




NANANA