<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25097

Description GM26770
SequenceMNQIEIQELTTHLSQALDQNYDVVNMDAVLYVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRAKSLLKKWREMVGIQQTATEYLAHPSQISPSQPALNLVKSPINSFITEPIAPSQQIVSDMHSNIDSAEPPLLGEHTLLHPNFSNLVNSIKDSDRHENIAITTFHTHKDRRHSHAIRSCHVASPQPIVIDHSINSVINLTEDSTVKINETSVVIDIASDSDENDNNSSLNPKKLNSIVPAPLPTPSTPSSRQRKLKKEKRSKEREGQVATNTRFGAKVSDTCQQAALTTDSEIFSLSNSSMSSIVSGDATLSYSQNKSRLNSNELTFTGRFKAVDHLFRSTESGKRKIDEYSAYDSNASCSRLSPSTVDEVKKAEHLFDAQLTNATANQMPMSAVGYESNTRHEYLESESPSQIPKRRGRKKGSKGVDALIAKESSSLSQQIFFGGSVKKVKTTKELFNEIQSRKLSVSMQSSASNLSNSSTNRDLTSHTTFPRQTSSCSDTSMHSPHILETLSGSAIFASKIDDLANTDSDTVTSDPSHDSNKSQEIKECTSLDSNSNSVQSLPLANNRENLIPKNVNDITTQLMHLIHSLNSPLSIIEIERVYQEKIIPCTCIVIEEVEGTLGESNNCTLDDQSKNAKISLNSKDNLSCHNRDNFPTSQRSINGEVIDTQPKLVKSIFDLDFDDNDDPLNLIMDEIQKPIARAEELKNNKSDTKNIHFGASAQNVSFNINFSDDAQQDNSNQEREKSETQNAIPAFTVHEDPDCLARQRFYIQTNKVTSFHINALHNYYIPNINGNWDSVESFTSFQPKHTIIDTMESYTVTNGADVVPKYGLLTSDRIRKDLSSLKSIKPYRVKKFTSFFSPFLGVAKCLPTCRRARRRLKNFVTLSTANDNTAKNFESLENMKASFKNCNPLNVKIDGTTSAIYSHNENHVPMQVNTNVEQLPPSQSFSGNAISYNLLKLADDKVRDDEISDKSSNHGCQENSPFSSSSSSGYSDSKEDQHNIIKNQQNKSIQLNSRNSDMNRRKRRIYLEDDSKKKKHYRKRIKAAVNGTCSNLHRNLNSSDSENGMENDYKNEYGNSNNEEYAIVQRPAGDGENCRNHIVLTIKKTPSKINSPANSMNAFSPSTTSDAANLKKSILDFCLEDTNISQSITEIPQKEKEDLSKSNRIVHQSRCSAYRRIFRKSDKSQTNFIDLELKHLFHLKSNPPCILANSKLHNKLFFPHELSRDNTSGIRERIINYSSSSSSSYDDDSEVENTSFVKKANVKKFSAYNNHNLKIETETCAATAISEFKFESDEDSMLTSLGDSDIDIQDGIHATNDSVDYCNDFQNNKMLESFNSIFVDSLRTNRKNASGNMESSPHITSLESLKPEDVDAITRYCNNNNLGVNLSNELSNISAKSIKSLDSTEKLPSLGIEHCTGIKTSSDLASTSIADKKLTRIQQFKEWHQVLQLKSYNNEPLIVLPYVLLE
Length1482
PositionUnknown
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.716
Instability index48.58
Isoelectric point6.51
Molecular weight165902.39
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:InterPro
nucleolus	GO:0005730	IEA:EnsemblMetazoa
pericentric heterochromatin	GO:0005721	IEA:EnsemblMetazoa
polytene chromosome chromocenter	GO:0005701	IEA:EnsemblMetazoa

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25097
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     757.04|     163|     164|    1062|    1224|       1
---------------------------------------------------------------------------
  530-  702 (104.78/55.72)	.........................S......KIDDLANTDSDTVT.SDPSHDSNKSQEIKECTSLDSN.SNSV..QSLPlANNRENLIPKN........................VN.............DITTQLM.HLIHSLN.SPLSIIEiervyqekiipctcivieevegtlgesnnctlddqsknakislnskdNLSC.............HN.RDNF.....PTSQrSINGEVIDtqpklVKSIFDldfDDNDDPLNL
  819-  929 (103.34/54.83)	.......................................................PKHTIID.TMESYTVTNGA..DVVP....KYGLLTSDRI...RKDLSSLKSIKPYRVKK.FTS.............FFS...P.FLGVAKC.LPTC......................................................rrarrrlknfvtlST..AND.....NTAK.NFESLEN......MKASFK...NCNPLNVKI
  930- 1099 (199.63/114.48)	DGTTSAIYSHNENHVP..MQVNTNVE......QL.PPSQS...FSG.NAIS..YNLLK.LADDKVRDDEISDKS..SNHG.CQENSPFSSSSSSgYSDSKEDQHNIIKNQQNKSiQLNsrnsdmnrrkrriYLEDDSK.KKKHYRK.RIKA................................................avNGTC.............SNLHRNL.....NSSD.SENGMEND.....YKNEYG...NSNNEEYAI
 1100- 1261 (228.80/132.56)	VQRPAGDGENCRNHIV..LTIKKTPS......KINSPANSMNAFSP.STTSDAANLKKSILDFCLEDTNISQSI..TEIP.QKEKEDLSKSNRI.VHQSRCSAYRRIFRKSDKS.QTN.............FIDLELK.HLFHLKS.NPPCILA...............................................NS................KLHNKLffpheLSRD.NTSGIRER.....IIN.YS...SSSSSSY..
 1262- 1404 (120.49/65.45)	....DDDSEVENTSFVkkANVKKFSAynnhnlKIETETCAATAISEfKFESDEDSMLTSLGD...SDIDIQDGIhaTNDS.VDYCNDF.QNNKM.L.ESFNSIFVDSLRTNRKN.ASG...............NMESSpHITSLESlKPEDVDA..............................................iTRYC.............NNNNLGV.....NLSN................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.90|      23|      26|      89|     112|       2
---------------------------------------------------------------------------
   89-  112 (35.89/25.69)	TEYLAhPSQ..ISPSQPALNLVKSPI
  117-  141 (37.01/21.13)	TEPIA.PSQqiVSDMHSNIDSAEPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     322.92|      82|     164|     254|     336|       3
---------------------------------------------------------------------------
  208-  255 (27.90/11.73)	...............................................LTEDSTVKI...NETSVVI.DIASdSDENDNNSSlNPKKLNSivpAPLPTPS
  257-  338 (129.26/78.14)	PSSRQRKLKKEKRSKEREGQVA.......TNTRFGAKVSD.TCQQAALTTDSEIFS...LSNSSMS.SIVS.GDATLSYSQ.NKSRLNS...NELTFTG
  339-  415 (83.76/49.21)	...RFKAVDHLFRSTE.SGKRK.......ID.EYSAYDSNaSCSRLSPSTVDEVKKaehLFDAQLT.NATA.NQMPMSAVG.YESNTRH...EYL....
  424-  501 (81.99/47.97)	PKRRGRK....KGSKGVDALIAkessslsQQIFFGGSVKK.......VKTTKELFN..eIQSRKLSvSMQS.SASNLSNSS.TNRDLTS...H.TTF..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25097 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QMPMSAVGYESNTRHEYLESESPSQIPKRRGRKKGSKGVDAL
2) RDDEISDKSSNHGCQENSPFSSSSSSGYSDSKEDQHNIIKNQQNKSIQLNSRNSDMNRRKRRIYLEDDSKKKKHYRKRIKAA
3) TCSNLHRNLNSSDSENGMENDYKNEYGNSNNEEYAIVQRPA
4) TSVVIDIASDSDENDNNSSLNPKKLNSIVPAPLPTPSTPSSRQRKLKKEKRSKEREGQVATNTRFG
5) VSMQSSASNLSNSSTNRDLTSHTTFPRQTSSCSDTSMHS
398
979
1064
219
477
439
1060
1104
284
515










Molecular Recognition Features






MoRF SequenceStartStop




1) YRRIFR
1190
1195