<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25096

Description GM19665
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHNSNVNASKVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQSHDKSSSNGTTSGSLTAAGNGPASNGTTGTTSINSVTGSNAPTNVIPVPSMASPLPPIHSPANGQQGAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAPGAGAAVPPGSTISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVSKKLAQLLNTVVEQQTIKELDEPKLQQDPYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGISAHRAPSSLLGSPLDHLPLAPSVLPMPTRCPRTNQEIRRQLRAAESDIVLRTQHAEQRWFAAKWLSAGKNQYTSVLATLDHLDTHCFDRMEHNNSIDTLYAQIFPSPTASRRREEDQVEPRPPYEPKQDKDTVRILCEWAVSGQRWGEHRAMVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVSSPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESMLVIKSGTTATKTSPPPPAPPPTTTHGFDDDGFGGGLDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGETNPGGSISRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAAAGHVKKHSRNEFNFEATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDSLLKELLEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHVSNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQLQCIKRFKDIFNTPEQLDLPPQGYNPLLLQELFIAPRRGGKLDPHWLGTLHESPANVYSFVSNALIAVCRETDNERLNDVALACAELTASCNVLSEEWIYALQSLCSGSKSPRYPHLGGQVDIGQVKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGNDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLVSGSGSCSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQISLLEFAQEPLLGTCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNNAELNVWLDTVARAAIDVFHMEEVVLPGAVKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVPKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDDERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSGMDTKGNKMCDIDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQSPSAVVGGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQPQNVQQQQLQQQQQQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNPNNMMQQNAMLQQQQQMQQMGNNPLQQQLNVGGGNGQQNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAPQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNANSKQALSQMLRQRQPFQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQINPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAVAQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVVGQVPPYARQQSAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGAGPQQAGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQYQPPPY
Length2518
PositionKinase
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.539
Instability index56.05
Isoelectric point7.43
Molecular weight278020.28
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25096
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     825.32|      67|      67|    2253|    2319|       1
---------------------------------------------------------------------------
 1904- 1973 (87.83/27.25)	.VG.G...TG..RGrGKGtttrkrkpK.....NPK.TPPVV..N..T.Q....QQQPQLA.....P.Q..P.....Q.QPQNV..QQQqLQQQQQQQQ...H......MQQQ.....Q..MQPN
 1979- 2043 (96.67/30.80)	PMNMP...MN..MQ.QFA........P.....NPN..NM....M..Q.QNAMLQQQQQMQqmgnnP.L..Q.....Q.QL.NV..GGG.NGQQNPQMN...F......MQQ......G..PG.G
 2044- 2085 (73.80/21.60)	G..............GAG...............P.....QG..M..P.GQ...QQQWHNA.....P.Q..Q.....QQPPQPY..HNQ.YAPHQQN............MQSN............
 2088- 2140 (66.92/18.84)	..........................E.....RPP.LNANS.......KQALSQMLRQRQ.....PfQ..Q.....QAQ.QGP..GGG.FNPMQQQPQ...P......SQQQ.....P..GPQQ
 2141- 2194 (65.30/18.18)	QI..............................NPN.....Q..M..R.QQQM...NPQQN.....P.Q..S.....VAAFNAM..QQQ.QQQNAQQQQmnpN......QQQQqqfmrG..G...
 2195- 2251 (80.13/24.15)	....N...MR..PG.MAP........N.....QMNqMNMGGqgM..P.QNPMMQQQI........P.Q..N.....MVGM..V...NP..NANQMMQS...G......GAQ.........GGNG
 2253- 2319 (147.60/51.28)	GVGVG...VG..VG.GAG........N.....NPN.MGMGG..M..P.QQGMMQQQPQQQ.....P.Q..Q.....QVQFQNF..QNQ.YQQQQQQQQ...G......MQQQ.....G..GGAG
 2320- 2378 (76.81/22.81)	...VG...VG..VG.MAP........NqqqqqQAN.M.MGN..F..N.PQ..MQQANRNN.....P............DFMAA..AAV.AQQQQQQQQ............QQ.....R..VVPG
 2379- 2461 (84.13/25.76)	GMMAG...NR..NQ.YMN........Q.....APN.VTMST..MmgPgPGGVVGQVPPYA.....R.Q..QsagggKPGVLNT..QQQ.FQQQQQQQQ...QlrhqqmMQMQ.....GmgGGAG
 2463- 2514 (46.14/10.48)	GMGAGpqqAGgaVG.GGG........G.....G....GM....V..P.QQQSMNQQ..QT.....P.NlvA.....QLQRQNMmgQQQ.YQ.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     309.98|     110|     154|    1513|    1666|       2
---------------------------------------------------------------------------
 1513- 1661 (152.65/164.91)	ARAAI.DVFHMEEVVLPGAVKATHK.PKPST.WlvAPLIAKLtpAVQGRI.LRVAGQVLES.MNYFSKVPKSdcnSSGSGDEREKSNschssnsyglggvparnkkmplnyqpflglILTCLKGQDEYKENL.......LVSLYAQLSQ...CLQSfaELDTIG
 1668- 1792 (157.33/86.43)	AREEIlDALQLRFSLVGGMFEAIQKnSTPTTdW..AILLAQL..VCQGVVdLSCNRELFTTvVDMLATLVHS...TLVSDDERHYMN..............................LMKKLKKEIGEKNNAsirvirqLLPLYKQPTEviaCEHS..GMDTKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.79|      15|      15|    1098|    1112|       6
---------------------------------------------------------------------------
 1098- 1112 (27.35/13.75)	QG..YNPLLLQELFIAP
 1114- 1130 (25.44/12.27)	RGgkLDPHWLGTLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      14|      15|    1276|    1289|       7
---------------------------------------------------------------------------
 1276- 1289 (25.24/15.22)	YSVSTSPNPLHAVG
 1292- 1305 (24.99/14.99)	FSIRLSCDRHLLVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25096 with Med12 domain of Kingdom Metazoa
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