<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25094

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEDWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGVGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMPNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNSMGGMGVNMPPNLQQKPNMPMSQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIDPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALEKMDLISYSGQQFGKSSNPLLEVINTTLQSPVANHTLYRTFRPTLELLFGTDITAPVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINNKTIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAVCELSTLLGV
Length690
PositionTail
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.637
Instability index63.97
Isoelectric point9.38
Molecular weight74914.00
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25094
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     464.59|      51|      53|     158|     208|       1
---------------------------------------------------------------------------
   69-  113 (44.09/ 9.08)	............QQQ...QQ.QQQQQ....G..GPPPNA.E...M..GGGQNmmqdplnalqnlasQGN..RN.P..Q
  114-  147 (54.24/13.17)	MMPMGV.GG.GA..........PVPG....G.....PGT.AsNLLQSLNQQR......................PGQQ
  158-  208 (108.09/34.89)	QMPMGA.GGAGAQQM...MQVQQMQQ....G..GNAPGV.M.NVMGAGGGQN..............QGQIVGN.PGQQ
  209-  242 (56.19/13.96)	...MGV.GVGMPNQM...M..............GMNP...M.MRMGQGNGMG..............GPQ..GM.PG..
  266-  295 (48.88/11.02)	.......GGAG.......LPPNAVQQ....G..G......M.NSMG.GMGVN..............M.....P.PNLQ
  299-  326 (54.85/13.42)	NMPMS...QAG..QM...FP.............GNRGGV......GV.GG..................Q...Q.PGQP
  327-  373 (56.84/14.22)	FMRSSP.SPADAQQLqqqAQLQQMQQqlvvG..NQTP.........T....Q..............QPPTPQM.PTPN
  374-  418 (41.42/ 8.01)	MIPSPAlVPQSSPQM...MQMQNSQR....NirQQSPSAsI.N........T..............PGQVTGNsP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.47|      42|      78|     552|     601|       2
---------------------------------------------------------------------------
  515-  550 (26.94/ 8.03)	..............LQSPVANhtLYRTFRPT..LellfgtDITAPVPAKRPR
  552-  593 (69.22/60.24)	EEKSTSFEQEVPHVLQGEIAR..LDTKFKVK..L......DTTSQINNKTIR
  630-  663 (38.31/20.17)	EYSATPFLQTVQQALIARISK..LPKNYSLShlL......DT..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.12|      33|      44|     434|     472|       3
---------------------------------------------------------------------------
  421-  470 (36.06/38.20)	PQeealyrekykqLTKYIDPLKRM.LakISNDGtnvEKMTKMSK.LLEILcN
  471-  512 (43.06/24.54)	PT....qrvpletLLKCEKALEKMdL..ISYSG...QQFGKSSNpLLEVI.N
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25094 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNVISKIHDLLPPNAQDQTKNAGVMENHIFR
2) YKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGVGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMPNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNSMGGMGVNMPPNLQQKPNMPMSQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEAL
12
61
42
426










Molecular Recognition Features






MoRF SequenceStartStop




NANANA