<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25091
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSNSVNISVETTCENQIREIGYDGTELYQPPPTLSESLAKCAARIDFSKTSLDDLKKEEKSAAAAADEDKDATQFQESLWPWDAVRNKLKDALTEICVLSDVISIAKDKRYLVLDPLLEEADDTKPIVQVYSRKKAISQAAQVLLSGAERLRNAHSEQRNRNVSDFHIELLRLRQNWRLKKVSNAIIGDLSYRTAGSKFGMSGTFEVTKAEETGDEDTPSSSNSSSSTSGNNGMQLKASSALRVIVPAELQGVAYIKVITQKDQEDLCTAQLNLMGHGPNITAQVGVWQKTLEFAQNVLFCKELFAQLAREAIQLQAPIPHVVIGNQIRATLLPNIQLIISLCHSTTFDSSQPAPINDHDHVLEHSLHQLLREVHYKNSHHPFPHPASAPLGPTKKRMLAGPMAADRETLLDMTKSQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMNSPTMSCVKINIVTHGYDAIGRTSLVIHVKERSLKCICRDGRVMRLSYEPQELRDLILCQINSHQISCLISLARCMSWTVLSNSNHLGVGKVEPLGNASSCLLASPNSDRMIAVQIRCDPQIDVKVYIARSPRQDFFPSPLVPEKLWENLGGTFKEVRFDKIEGKSFLNKMEFLMASLTSNTA |
Length | 642 |
Position | Head |
Organism | Drosophila sechellia (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila> Sophophora.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.292 |
Instability index | 44.02 |
Isoelectric point | 7.02 |
Molecular weight | 71570.03 |
Publications | PubMed=17994087
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblMetazoa
pericentric heterochromatin GO:0005721 IEA:EnsemblMetazoa
|
GO - Biological Function | activating transcription factor binding GO:0033613 IEA:EnsemblMetazoa
transcription coactivator activity GO:0003713 IEA:EnsemblMetazoa
|
GO - Biological Process | cellular process GO:0009987 IEA:EnsemblMetazoa
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblMetazoa
sex comb development GO:0045498 IEA:EnsemblMetazoa
|
Interaction
Repeat regions
Repeats |
>MDP25091
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 172.95| 50| 161| 356| 407| 2
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356- 407 (83.49/62.06) INDHDHVLEHSLHQLLREVHYKNSHHpFPHPASAPLGPTKKRMLAGPmAADR
520- 569 (89.45/56.57) INSHQISCLISLARCMSWTVLSNSNH.LGVGKVEPLGNASSCLLASP.NSDR
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