<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25090

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGSNAKSSGTGFGSHIPSIEEKNKQIQQETMMEKLRAKYRNKPKSYEEIKKSVRMYFIEKHYPLDPLCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDAAGSLSDVKVHHECKIEQQSSELVACLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIQSLYQLHLQSHSGDSYSLMTSSSVGLVLPRRGGHPMKLTYFCPPLHLPEGDPKLASGDFTIDQVMRSSYGLSATINLEGSSANKLQTLPTVTLVRDSQTGLEVPTYAQLNQNNSLLMPATYVLRLNKPMPVCLESLKALGLPGLDSVATPPSPPTTVLNLIVQTASKQAIKNTQRGLYVNLPKETHCYFFTDNRKLQGTLVSSLPFTEPAQVPRIVAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQPTCSVYCLTNEYELLSQKLTRTVRKVVSIPMVIYKLLKCWDEEHEFKLHGAIGPGAGSGAIGGGGMSGGGPVSGVGNSFSQFAMDTTTPTDGSLPGGGFTNINNLKMDAKSRSLADAFAASTSAAAAIAGLINLKRETDPQSACSSSGTTVSGSSGSSGSAKTSDHDIADKYKNIWKDKTPNLKHCVSITPIPGDGKSGSAGGVSGVEVQRTGGIEIIPLNAQAAVAGGGVQASSSATPTTITITPITGKDPSKDSTKKSTSVSAGVGVAAKRPHESSTSSSSTSGGSGSGSSMSSSASSGSSDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAGGGDASATGGVVRKFSSPSSSPKAGGAGQGLMAGVPTARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATILSPKGDKSSSAVGSTSSGPSASSGSGGATGLVRSFASVGAPPPPPPIPPLASASGSISSSQSLKKEKTSSASGSNSTTSSATAGVSSGGGISPASVAAAVAALKSSQQQLKSVASLSHLAAGGGLGSYAAPSGAGVPGAAAVVVGAGAGAGAGASGLEMSALRKGMAGGAVSLMTSTAALAPTIPAPTTTVAAGAAGSAASLVSPVSAVVGQGQETAGAAAAATLATATILQQQQQPGAAPTSSCLTTSGGSNDSAGSSNPAGASTEYMVKPSSQEGLKLTINKTGSSKSSGSGSSSSSGLQAKAKSSSIGATSFAGSTGSTKKQHTGLKPGVNSGPASKKATAAVSSATASSSKHFFQKANSSGNLSSKLSGSGAGGGIPLTKSNSTNSFQEHNAPRRRPSMGALASGSSAGGSGQRKLGSTSAGGSGSSGSVSPALSGSMSQPPPRFDHHTDMMTILQYASPTMAASMEGFIKGLHNKFQIPKLSQRGSGCNTNSGRSTPSGSSEPASAGTSSSILGPAASSTGLTEPEAKPPVPPPPSGNEGLLNLSSTAGTPSADGIDEELLASLAGE
Length1476
PositionMiddle
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.283
Instability index52.81
Isoelectric point9.37
Molecular weight149771.04
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            13|     905.72|      90|      91|    1162|    1251|       1
---------------------------------------------------------------------------
  526-  598 (45.08/ 8.11)	...........KLHG.AIGPGAGSG..............AIGgggmsgggpvsgVGNSFS................................Q.....FAMDTTTPTDGSlpG...GG.F...TNINNLKMDAKSRSL..AD....AFA
  599-  648 (47.21/ 8.88)	A...ST.SAA.AAIA.GL...IN..............................................lKRE.TDPQ.........S.................ACSSS..GttvSG.S...SGSSG.SAKTSDHDI..........A
  649-  727 (50.86/10.19)	D...KYKNIW.KDKTpNLKHCVSITPIpgdG.K.SGSAgGVS...............................gVEVQ.........RTGGIE.....I.IPLNAQAAVA..G...GGvQ...ASSS...A..TPTTIT.IT....PIT
  728-  779 (60.91/13.83)	GkdpSKDSTK.KS.T.SVSAGV..GVA...A.K.RP................................H.ESS.TSSS.........S...........T......SGGS..G...SG.S...SMSS....SA...S...........S
  780-  837 (63.02/14.59)	G...SSDTQKeKKRK.KKRDDSPMGPP...E.K...................................................................IYSRQNSPAG..G...GD.A...SATGGVVRKFSSPS...SS....PKA
  838-  940 (81.04/21.10)	G...GAGQ........GLMAGVPTARP...S.P.KHSP.VYS..spkhntasnsPKSPFGThspkhgSS.G....KP..........SMSTLKsaataATILSPKGDKSS..S...AV.G...STSSG..PSASSGSGG.ATglvrSFA
  962- 1054 (88.19/23.69)	S...SSQSLK.KEKT.SSASGSNSTTS...S....ATA.GVS.........sggGISPASV......AA.AVA.ALKS.........SQQQLK.....SVASLSHLAAGG..G...LG.SyaaPSGAGVPG.AAAVVVG.AG....AGA
 1055- 1130 (72.35/17.96)	G...A.GASG.LEMS.ALRKGMAGGAV...SlM.TSTA.ALA............PTIPAPT......TT.............................VAAGAAGSAASL..V...SP.V...SAVVG.QGQETAGAAA.AA....TLA
 1131- 1220 (117.19/34.16)	T...ATILQQ.QQQ.....PG..AAPT...S.ScLTTS.GGS.......ndsagSSNPAGA......ST.EYM.VKPS.........SQEGLK.....LTINKTGSSKSS..G...SG.S...SSSSGLQAKAKSSSIG.AT....SFA
 1221- 1295 (105.71/30.02)	G...STGSTK.KQHT.GLKPGVNSGPA...S.K.KATA.AVS.............SATASS......SK.HFF.QKA........................NSSGNLSSK..L...SG.S...GAGGGIPL.TKSNS...TN....SF.
 1296- 1353 (65.17/15.37)	........Q...EH.........NAPR...R.R.PSMG.ALA..........sgSS..AGG......S...................GQR..K.....LGSTSAGGSGSS..G...SV.S...PALSG......SMSQP.PP....RF.
 1354- 1427 (59.79/13.42)	.........D.H.HT.DMMTILQY.................A............SPTMA.A......SM.EGF.IKGLhnkfqipklSQRGSG.....CNTN.SGRSTPS..G...SS.E...PASAG....TSSSILGpAA....S..
 1428- 1475 (49.20/ 9.59)	....STGLTE.PE....AKPPVPPPP...................................................S.........GNEGL......LNL.......SS..T...AG.T...PSADGIDEELLASLAG..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.75|      20|      92|     155|     178|       3
---------------------------------------------------------------------------
  155-  178 (26.32/27.77)	LKSGdfaDFTVQlEGLSSIYQLNA
  251-  270 (36.42/22.17)	LASG...DFTID.QVMRSSYGLSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.22|      16|     596|     343|     363|       4
---------------------------------------------------------------------------
  343-  363 (24.91/21.45)	SVATPPSPPTtvlnlIVQTAS
  941-  956 (34.31/17.78)	SVGAPPPPPP.....IPPLAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25090 with Med1 domain of Kingdom Metazoa
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