<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25089

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSTKTDNADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAATAGGAVPNPQDPNGASMDGLDSGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFRCAIRTTRMSHPWWKWCRVSGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAAESAVLASLSCPPGAAAAPSSMGAAPSATAVPLGPASLNAPALAGAGVGATASSAAKEISRKAAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAAASSTPALGTGSSSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTNAQCSSSSNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSYQQQHYHQQHLQQQQQQQRPGTPVLPATAATSSHHSSSLGNTSASNSSAATPRRHNVPFHKRLLHSLASTASSTASTFRAKNHSNTTTDTNIPKQRHLGNTPHETPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQSLGTGPGSVPTQQPATPTAATSAGGAGSCGPSNAIGGNAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGRGVGGVTSTTEALNNFKRLYNPPKLTLKDPDSFYDGEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRKPRYAKNLYEGQNHVKPDMPSPGSVYGSQLLSLDESASAAGGGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAVASGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIMLATAQAPVTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQTQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQQAAAAAAAAAAGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASPATSTSSYLNRPLHSQEHPHMHGMGGGATGGVGHGTGGGGHMGMVPYTGDAGIASGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPSGAGGAAAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGCSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLSIIQSLSRKNQIKQGPGETSSALDKIGAGGLPGGQLEQLAHAVFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRIFGTNGAPTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWSYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVSCTRSYFRELSSTYEMCKLGKHTPIRGWDGFLQVGAARNNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGTGNSHSKGGSSSSSNSSSGSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGAAAGETKPALILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGDLFWGTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTTPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSANDHPLDSILTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2761
PositionMiddle
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.412
Instability index52.44
Isoelectric point6.48
Molecular weight295336.94
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25089
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     207.89|      29|      32|     703|     731|       1
---------------------------------------------------------------------------
  670-  689 (25.29/ 6.61)	..NVP.FHKRL.......LHSLASTASST..A
  703-  731 (51.93/22.27)	DTNIP.KQRHLGNTPHETPHGGASTYSRN..S
  735-  757 (28.95/ 8.76)	DSSMPvASVESPATPAPSPHP.......N..S
  762-  784 (36.49/13.19)	PTSVP.PAEQLLNM...SPH..APT.SVS..N
  850-  878 (38.77/14.53)	PGSVP.TQQPATPTAATSAGGAGSCGPSN..A
 1391- 1416 (26.46/ 7.29)	.GGVG.HQKH....QHQHLHDLLSAAPRTplT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     145.90|      22|      22|    1442|    1463|       2
---------------------------------------------------------------------------
  258-  279 (36.77/13.25)	PNGASMDGLDSGEGAAKAAPPP
 1442- 1463 (43.04/16.76)	PPGASMQQLMHRAGMSPISPGP
 1466- 1485 (38.56/14.26)	GPYAARSSPMSRA..TPTHPPP
 1495- 1514 (27.54/ 8.10)	SPATSTSSYLNRPLHSQEHP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     134.58|      21|      21|    1645|    1665|       3
---------------------------------------------------------------------------
  999- 1018 (26.61/11.07)	PSPGSVY...GSQLLS.LD.ESAS....A
 1030- 1049 (26.73/11.16)	SSGGGLV...GIANSTA.S.GSDV....E
 1051- 1076 (23.67/ 8.84)	DGSSFFQ...GLNIKTEPGlHSPScketS
 1081- 1102 (20.91/ 6.75)	GNSSGGGsgsGGNLFTAEG.LNP......
 1645- 1665 (36.66/18.68)	PSSAGFG...GMRMISAFG.GSPA....S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.84|      40|      82|     510|     556|       4
---------------------------------------------------------------------------
  510-  542 (46.95/18.34)	.............................................PAL......GTGSSSADGDENEQN.KPPQDSKQLVQQQIQ
  543-  626 (49.09/32.02)	QQQQRQKlwnfvdpmqkapcictnaqcssssnisnnkrpqqplgsPALraavtgGSGNKSSSSSSSSSS.SSSYQQQHYHQQHLQ
 1347- 1369 (35.80/13.23)	QQQQHQK..............................................................hQALQQRIQLHQQKLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.41|      16|      33|      31|      48|       5
---------------------------------------------------------------------------
   31-   48 (26.79/22.17)	WRKFVNGERPNAssDPLA
   67-   82 (30.61/18.39)	WRRVQSTKTDNA..DPNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     243.90|      51|     145|     187|     253|       6
---------------------------------------------------------------------------
  187-  237 (84.27/36.45)	RSSQHLSFSFTFFVHGDTVCASIDLREHPAVRP.....LTKEHLTEAAAA.....FAAASS
  336-  387 (68.89/27.15)	RVSGHKMYHPTNYV....LVTDLDDMEHMEFVE.....MQKMQSSVAGAAaesavLASLSC
  455-  508 (75.25/31.00)	YYDQRPTSGFTFNTNNTHIPASAAV.EMPE.RTwqdcvMNTLHVDAAAAA.....AAAASS
 1143- 1165 (15.48/22.91)	....................NTIEDLKRSTAVA...........SAAVAA.....AAAA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.30|      19|      25|    1523|    1541|       7
---------------------------------------------------------------------------
 1523- 1541 (38.02/22.08)	ATGGVGHGTGGGGHMGMVP
 1549- 1567 (31.29/16.50)	ASGGTAMAAGSSSLLQELP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.88|      15|     145|     238|     253|       8
---------------------------------------------------------------------------
  238-  253 (25.28/16.84)	PPGSnGSAATAGGAVP
  388-  402 (29.60/14.83)	PPGA.AAAPSSMGAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.21|      16|     145|    1621|    1639|       9
---------------------------------------------------------------------------
  824-  844 (28.14/ 9.30)	PSV..EP.PSytdhaAGGGPAGGQ
 1621- 1639 (26.07/17.28)	PGVsfNPfPS.....GAGGAAAGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.73|      17|     744|     627|     643|      10
---------------------------------------------------------------------------
  627-  643 (31.48/18.29)	QQQQQQRPGTPVLPATA
 1374- 1390 (27.25/14.64)	QNQQQQQAAAAAAAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.10|      19|      23|    1669|    1687|      11
---------------------------------------------------------------------------
 1669- 1687 (37.95/17.46)	PGAGSGHGHG.....PNGCSNSSS
 1690- 1713 (33.15/14.22)	PPSSNPHITGyvdddPVECTCGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.20|      14|      23|    1198|    1214|      12
---------------------------------------------------------------------------
 1198- 1214 (21.20/24.19)	CQTDVVMtdlSVDTTTT
 1224- 1237 (26.00/18.29)	CNTTITS...SINTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.52|      44|     217|    1980|    2026|      13
---------------------------------------------------------------------------
 1980- 2026 (76.62/54.81)	GRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYwdkFLLEPYSYARD
 2196- 2239 (74.90/44.74)	GAAAGETKPALILGDPLGMGETLEDINPSAIVL...YVVNPFTFASD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     393.83|     126|     872|    1717|    1860|      14
---------------------------------------------------------------------------
 1726- 1857 (196.70/145.80)	LFYEDEVEITGIADDPGRNKQPTLLsiiQSLSRKNQIKQGPGETS..SALDK..IGAG....glPGGQLEQLAHAVFDLLLDQCSIIQTSSSSVH.RALQSHRRRMSRQRRIFGTNGAPTASLASiANVLEF.MDAHDVIS.L
 2592- 2730 (197.12/111.09)	LFWGTHMDRVSNHGSPGRMDDNRSW...QSAGGNNFKCTTPQEVEevGSLNQqpISVGymvstaPTGRMPAWFWSACPHLEDVCPVFLKTALHLHvPSIQSADDILNSTNAHQSANDHPLDSILT.ADVLRFvLEGYNALSwL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.28|      18|      23|    1276|    1293|      15
---------------------------------------------------------------------------
 1276- 1293 (36.94/19.43)	GSPMEEPINDWDYVYRPP
 1300- 1317 (33.34/16.77)	GSTRYAPLTNLPSQTQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.38|      15|     150|    1915|    1929|      16
---------------------------------------------------------------------------
 1915- 1929 (29.93/18.46)	VHKW.SYLPVGFTRSN
 2065- 2080 (24.45/13.58)	IRGWdGFLQVGAARNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.00|      25|     498|     417|     441|      17
---------------------------------------------------------------------------
  417-  441 (41.11/21.52)	PALAGAGVGATASS..AAKEISRKAAP
  909-  935 (40.89/21.36)	PGAQGRGVGGVTSTteALNNFKRLYNP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25089 with Med13 domain of Kingdom Metazoa
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