<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25086

Description GM15969
SequenceMETQVIDTVNEFLKVDSLDEAFVSVIVFKPNSEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAGASGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPYHWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTEANDASTGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQIPAVTFSVTVLDSLTVHSKMSLIHSFVTQMLKQAQTKGQVPAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLHSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTLARSMHVHGGGDEMQGWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQSQDSLWTPELSYYMSLIRRLADTISGKNVFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELFNFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIAVLLYEILEIVDKQHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHTEKINDNTSNNAITSQTQSPMQTQHQQQPQQSHQQQQQTHQQPQQPHQQQQQQQQQMQQQQINPVQTTSVPLGSGGNLQQQQQINQQQQMYMQHMQQHQHMQNMRHN
Length1440
PositionTail
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.10
Grand average of hydropathy-0.180
Instability index42.85
Isoelectric point7.51
Molecular weight167143.42
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25086
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     105.90|      16|      16|    1355|    1370|       1
---------------------------------------------------------------------------
 1351- 1366 (30.81/13.95)	QSPM...QTQHQ.QQ..PQQSH
 1367- 1383 (28.84/12.62)	QQQQ...QTHQQpQQ..PHQQQ
 1384- 1401 (26.87/11.29)	QQQQ...QQMQQ.QQinPVQTT
 1419- 1435 (19.37/ 6.21)	QQQQmymQHMQQ.HQ..HMQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.35|      43|      54|    1004|    1056|       2
---------------------------------------------------------------------------
 1004- 1056 (63.79/61.92)	LHYYERILRdrpalkkKLVGAITSA.........FSEIrpPNWSvSEPYKVYLQSQDSLWTP
 1058- 1107 (61.94/36.18)	LSYYMSLIR.......RLADTISGKnvfystdwrFNEF..PN...APTHALYVTCVELLGLP
 1140- 1166 (40.62/19.21)	..................VGIVLAA.........LPE...PYWS.....GIYDRLQDMLNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.63|      30|      36|    1278|    1309|       3
---------------------------------------------------------------------------
 1278- 1309 (51.57/38.43)	KPLQYMDqiCDFLYHIKY..IHVGNIIKNESE.AI
 1314- 1346 (44.06/26.34)	RPLLQMR..LRFITHLNLedIHTEKINDNTSNnAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.36|      52|      76|     775|     828|       4
---------------------------------------------------------------------------
  775-  828 (84.32/68.08)	NDIIAHFLRPTTNPLFLCLLFKIiwETENISPVAYKILE..GISARALSTHLRKFC
  853-  906 (85.04/60.44)	NNMIWKFNVVTIDRVVLCLALRT..HEGNEAQVCFLIIQllLLKASELRNRVQEFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.02|      20|      21|     255|     274|       5
---------------------------------------------------------------------------
  255-  274 (36.54/20.17)	PYEPEL....LEEQK.PLLRY.VLEQ
  275-  300 (21.01/ 8.51)	PYSREMvsqmLNLQKhQKQRYnALEE
  333-  352 (38.47/21.62)	PYEWMW....LHLSS.QLIYF.VLFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.05|      25|      25|     943|     967|       6
---------------------------------------------------------------------------
  177-  203 (27.97/15.76)	..LPAYFiANE..IMRPFPYhwkLN..RLMTDF
  943-  967 (46.89/32.10)	IPLPVYF.SNV..CLRFLPV...LD..VVVHRF
  968-  992 (25.20/13.37)	IELTI...TNVhqILGF..I...LDhlSILYKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.65|      20|      26|     627|     649|       7
---------------------------------------------------------------------------
  627-  647 (30.24/19.68)	LSLLHSLSSVPQTNKMQlNLC
  694-  713 (34.41/13.07)	LTLARSMHVHGGGDEMQ.GWC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.37|      21|      26|     438|     458|       8
---------------------------------------------------------------------------
  407-  435 (20.86/ 9.96)	DLlypelepLKLPDINKSSMVRHMaPICV
  438-  458 (34.72/21.85)	HL.......MKKARVENMNITRPL.PIAL
  467-  487 (31.80/19.34)	HL.......VTANTMMNMTLGNDF.RIIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.60|      10|      25|     204|     213|      11
---------------------------------------------------------------------------
  204-  213 (17.59/11.11)	VEEFRTTAQM
  226-  235 (20.01/13.71)	VEHFGYADHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.37|      16|      75|     662|     677|      13
---------------------------------------------------------------------------
  648-  663 (21.68/15.26)	FESTALRLITSIGSAE
  664-  679 (27.69/21.91)	FQPQFSRYFNDKSPGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.32|      32|      37|     520|     552|      14
---------------------------------------------------------------------------
  520-  552 (51.30/40.13)	GQIPAVTFSVTvLDSLTVHSKM.SL.IHSFVTQML
  559-  592 (45.03/29.97)	GQVPAAALLET.YARLLVYTEIeSLgIKGFLSQLM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25086 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHTEKINDNTSNNAITSQTQSPMQTQHQQQPQQSHQQQQQTHQQPQQPHQQQQQQQQQMQQQQINPVQTTSVPLGSGGNLQQQQQINQQQQMYMQHMQQHQHMQNMRHN
1332
1440










Molecular Recognition Features






MoRF SequenceStartStop




NANANA