<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25079

Description GM14346
SequenceMAPTPLPLEQMPGVGGGGGGYLPAAQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNGDRSKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLVQPDQEILQPGRHKIYVKLHRHPNIVLVVQLKEKTTMPNEMEYTFHLGFVAFQKDELDVIDDSAMQLVSIVAQPHSDIPKCYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFANQQQQQQGAPAGSGENKPTGTSGLPKIDSHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFYSTPLQSCHPKEQGSRRTVYLTYEQANYDFSKTVEDLLNDWSKIVYLYALVYDFAEQLQNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNGHSMMRDQLAQHLNQHHSITQIAQILHETYNPLSSIAKLPVLPFLGIPRPQVPVLSFCVLAQSPCLIRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEEFTPIQGLKAFLSKYVDESAVYRGRASHEDDNPLSPMGLEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGADRGGSRGTLNRPWAGAVPTLLTHEALETLCRSSPYPNKDINVPDMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKVSQLPPMPDKHPPPFQLSQDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLDLKPELGGDQLKWTVQICLRMPPSAVPIVPSGNACVVMGRMKILFFLLITRIPYGAVIGQGKDWKDSPSLVLPIVYDIQTNVTQLAERTGQVISPTMTAASTLLRRFADFNAQQNQCTLFPAITDLLTNLQLAAEMPQPPPNQSIGPPVGVGVGVGVGVGVGSSPNPMMPMQQLPQQVGPQGPVGPGGYPQMGPNPGGPQ
Length1559
PositionTail
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.250
Instability index53.45
Isoelectric point8.26
Molecular weight172686.45
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25079
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.95|      26|      40|    1003|    1028|       1
---------------------------------------------------------------------------
 1003- 1028 (44.27/17.71)	RGRA.............SHEDDNPLSPMGLEDNFGGPSS
 1046- 1067 (40.98/15.79)	RGPQ.............SPRD....SGLRFPAPHTPPSS
 1086- 1111 (51.74/22.09)	SGPQ.............GHGNFNLTSPPAPHMPHPSPSG
 1504- 1541 (32.97/11.10)	IGPPvgvgvgvgvgvgvGSSP.NPMMPMQQLPQQVGPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     408.94|     194|     505|     736|     986|       2
---------------------------------------------------------------------------
  316-  437 (88.03/38.71)	YVPGVKLTVS.YWrDLKSElGYRLTVQSDPSEI.GRPLAvvhvpslgakesaevadRAVRSEHLSMERLIVHTVYI..RSVSRLSDL.KLEFQAFLkdvdfnlqGTPAIlTVPVLSPCLRAEQ...IHIT.........................................................................................................................................................................................................................................................................................................................................................................................................................................
  736-  844 (114.33/85.71)	..................................................................................................................................idthtgmfrchvpkhldcpiteemqdclngdrsklpallselrfwithrrcdktlqhlpatatetlpflvqpdqeilqpgrhkiyvklhrhpnivlvvqlkekttmpnemeytfhlgfvafqkdeldviddsamqlvsivaqphsdipkcytklmrliefdtfvathgpgtevdaevsphkrksngdllappakqqktifpayfipelahvvamcdekipfmnlaqtlskhniphsglqveanatslvlkilalpqpgkttfanqqqqqqgapagsgenkptgtsglpkidshvwddlMRRVLSISIRSQ...TNKNSqVRIWVVefVFYSTPLQsCH.PKEQGSRRTVYLTYEQ..ANYD.....FSKTVEDLLndwskIVYLYALVYDFAEQLQNKRL.SLCDML.....VVKSY.SYMNLLL
  846-  947 (105.30/139.81)	YGPKKEVSCNiYW.SVQSH.GFRLTFVGGMSAVnGHSMM.................RDQLAQHLNQHHSITQIAQIlhETYNPLSSIaKLPVLPFL........GIPRP.QVPVLSFCVLAQSpclIRLT.........................................................................................................................................................................................................................................................................................................................................................................................................................................
 1244- 1361 (101.29/45.45)	....................................................................................................................................yqavyclelrfranrlvsirdgassrfernvveeftpiqglkaflskyvdesavyrgrasheddnplspmglednfggpssvagvsaggsspflgtgmrgpqsprdsglrfpaphtppsssnphtpasphpsagagggsgpqghgnfnltsppaphmphpspsglmpssplnpqpsphmvhspgpntlymqshqdspftamspannnwpgspsmprpsprpgqspehkstgggaggaggadrggsrgtlnrpwagavptllthealetlcrsspypnkdinvpdmsplerflgcvyMRRQLHRNIQSEetlTALNS.TEPGVV..LFKVDGLQ.CQvVLNQMHMQTLHLKVSQlpPMPDkhpppFQLSQDDLL.....VIEQYFDTRVAAPPYRPNSLhSICRLLnlpaqVLKDFvQIMRLDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.52|      17|      39|    1114|    1130|       3
---------------------------------------------------------------------------
 1114- 1130 (36.36/16.60)	PSSPLNPQPSPHMVHSP
 1137- 1150 (26.95/10.20)	MQS...HQDSPFTAMSP
 1156- 1172 (36.20/16.50)	PGSPSMPRPSPRPGQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.26|      28|     366|     117|     150|       4
---------------------------------------------------------------------------
  117-  150 (37.18/39.63)	ETADMLARMSRETlvrarLPnFHIPAAVEVLTTG
  490-  517 (49.08/32.36)	KTLQHLPATATET.....LP.FLVQPDQEILQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.23|      23|      38|     255|     277|       5
---------------------------------------------------------------------------
  255-  277 (38.58/27.46)	LQVNYIH..QLIQARLVENPNALSE
  291-  315 (33.65/22.94)	LEVLYTQtlRLNYERLDDNNITVEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.39|      27|      38|     655|     683|       6
---------------------------------------------------------------------------
  655-  683 (41.54/25.31)	KIPFMNLAQtlSKHNIPHSGLQVEANATS
  696-  722 (46.85/23.56)	KTTFANQQQ..QQQGAPAGSGENKPTGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.73|      15|    1525|      17|      31|       8
---------------------------------------------------------------------------
   17-   31 (31.61/18.31)	GGGGYLP..AAQEGGPR
 1180- 1193 (26.84/14.10)	GAGG.AG..GADRGGSR
 1544- 1559 (28.27/15.37)	GPGGY.PqmGPNPGGPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25079 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GVGSSPNPMMPMQQLPQQVGPQGPVGPGGYPQMGPNPGGPQ
2) YRGRASHEDDNPLSPMGLEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGADRGGSRGTLNRPWAGAVP
1519
1002
1559
1205










Molecular Recognition Features






MoRF SequenceStartStop




NANANA