<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25072

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMSNYGNMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLTKFKEKKFKESLASFLQNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTPVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKQKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGMGMLPGGAGLGGAAGVMGATSLGSLGGGPGPGLSSLSASMGPGVVGNMNSFSSSMQMQQQQQMPMQQQQMSSGGLLGSVLGTSGGPGGGGGGGGGGGGGGGSLLMSQF
Length335
PositionHead
OrganismDrosophila sechellia (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.727
Instability index59.68
Isoelectric point9.93
Molecular weight35253.89
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:EnsemblMetazoa
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25072
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      18|      78|     232|     249|       1
---------------------------------------------------------------------------
  232-  249 (34.13/ 9.26)	PGGAGLGGAAGVMGATSL
  313-  330 (36.24/10.21)	PGGGGGGGGGGGGGGGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.05|      14|      46|     160|     173|       2
---------------------------------------------------------------------------
  160-  173 (27.28/18.24)	RKHKNKHKKQK.HKD
  190-  204 (21.13/12.67)	ETYEKKHKKQKrHED
  208-  221 (22.64/14.04)	RKKRKKEKKRK.KKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.61|      33|      33|      40|      72|       3
---------------------------------------------------------------------------
   16-   36 (21.60/ 7.46)	...........PHGGGRSPvVAR..QDSSG..TLKT
   40-   72 (58.77/32.56)	LGKTPTIIHTGPFYSMKEP.PAK..AELTGDKDLMT
   76-  107 (45.24/23.43)	LHHTLTKFKEKKF...KES.LASflQNIPGINDLIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.00|      15|      46|     251|     268|       4
---------------------------------------------------------------------------
  251-  268 (23.48/16.74)	SLGGGPGpglSSLSASMG
  298-  312 (27.51/11.41)	SSGGLLG...SVLGTSGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25072 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPLTPVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKQKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGMGMLPGGAGLGGAAGVMGATSLGSLGGGPGPGLSSLSASMGPGVVGNMNSFSSSMQMQQQQQMPMQQQQMSSGGLLGSVLGTSGGPGGGGGGGGGGGGGGGSLL
2) MMSNYGNMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISL
130
1
331
40










Molecular Recognition Features






MoRF SequenceStartStop




1) GGGGGSLLMSQF
2) GLLGSVLGTS
324
301
335
310