<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25065

Description GL15740
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHSSNVNASRVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCIVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQTHDKASSNGSHSAGLTTASSGNSNGISVNSSGGNAAPPSATANVIPVPSMSSPLPPIHSPANGQPSTAGGVVGSGSVIPPAGALGGGVSSGPGGPGGSSANSSTAVGAPVPPGSSISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVSKKLAQLLNAAVEQQGIKDVDGGVGAGAGGGENKLQHDPFELALQEQMSCPHHRDIVLYLSTILQIITIECPTALGLDPLDHLPLAPSVLPMPTRCPRTNTEIRRQLRAAESEIVLRTQHAEQRWFASKWLSAGKNHYTKVLATLDHLDTHCFDRMEQCNSIDTLYVHIFPRRRDEDQQDPQQQQQPRPVYEPKQDKDTVRILCEWAVSSQRWGEHRAMVVANLLDKRQIDVTSTPSEQSSDKEDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDDHLSSAQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLSLESVLASKSSTTATKSSPAAAATQATTTHGFDDDPFGGGIDFKHNEFDDSNVDDDLDKLVQNIKEKGQHDAPDSPKIGPPGDGEPSTGGAGGSISRHYVYTKHFPIPQDESSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTAKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDNLLKELPEVEHQLQLKKSNMVRGYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHVNNPSECSSAERCILAYLSDLHESCVLLQGKEQSTEYYQQLQCIKRFKDIFNTPEQLSLPPQGYNPQLLQELFVAPRRGGKLEPHWLRQLHESSANVYSFVSNAVIAVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGGQVDIGQGKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGGEMSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGSDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTSMAGGTGSSSSGGVGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGNSLTSEQEALQQPSVGGLEQISLLEFAQAVLKQICAQEHVLERCLKNAEGLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRAMIVRILENLGQWTLRISWLDLQLMYRQSMGNNAELNVWLDTVARAAIDVFHMEEIILPGSLKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGIGGVAARNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYSQLSQCLQSFAELDTIGGTDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDSQSERDENKKLYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDTKGNKICDMEKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMMKADTPSSVDQSPSAVVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQPPNVQQQQQQMQQQQHMQQQQMQPNQMGMQMNMPMNMQQFAPNPNMMQQSALMQQQQQMQQMGTNQLQQQLNVGGGNGQQNPQMNFMQQGPGGGAAGPQGLPGQQQQQQWHNAPQQQQPPQQYHNHYAPHQQNMQSNRIERPPQNANSKQALSQMLRQRQPFQQQQQQQPGGGFNPMQQQQPQAQQQPGPQQQQMNPNQMRQQQMTAQQNPQSVAAFNAMQQQQQQNAQQQQQQMNPNQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGIPQNSMMQQQMTQGMVGMQGMMQQQAQQQPQQQLQFQNFQNQYQQQQQQHQQQGMQLHGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAAQQQQQQQQQRGVPGGMMAGNRGQYINQAPNVTMSNMMGPGPGGVGVGVGVGVGQVPPYARQQPAGGGKPGVLSTQQQFQQQQQQQQLRHQQMMQMQGMGGGGGGGMGAGPQQASGAGVGGGGGGMVQQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQHQPPPY
Length2499
PositionKinase
OrganismDrosophila persimilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.556
Instability index55.32
Isoelectric point7.77
Molecular weight276106.56
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25065
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     888.99|      85|      85|    2154|    2238|       1
---------------------------------------------------------------------------
 1962- 2012 (93.41/25.78)	QPPNVQQQQQQM....Q..QQQHMQQQQMQP........NQMGmQM..NM.....PM.N........MQQFAPNP..........N...........MMQQS
 2013- 2077 (115.97/33.71)	ALMQQQQQMQQMGTNQL..QQQLNVGGG..NGQ....QNPQMN.FM..QQG....PG.GGAAG....PQGL.PGQQQQQQW...........H...NA..PQ
 2078- 2142 (103.80/29.43)	QQQPPQQYHNHYAPHQQ..NMQSNRIE..RP.......PQNAN.SK..QALSQMLRQrQPFQQ....QQQ..............QQPG..GGF...NPMQQQ
 2143- 2185 (90.98/24.92)	QPQ.AQQQ.....PGPQ..QQQ................................................MNPNQMRQQQMTAQQNPQSVAAF...NAMQQQ
 2186- 2272 (160.94/49.54)	QQQNAQQQQQQMNPNQQ..QQQFMRGGNMRPGM....APNQMN.QM..NMGGQGIPQ.NSMMQqqmtQGMVGMQGMMQQQ..AQQQPQQQLQF...QNFQNQ
 2274- 2338 (106.69/30.45)	QQQQQQHQQQGM....Q..LHGGGVGVGVGVGM....APNQQQ.QQqaNMMGNFNPQ..................MQQAN...RNNPDFMAA.....AAAQQ
 2339- 2411 (99.70/27.99)	QQQ..QQQQRGV.PGG.......MMAGN.R.GQyinqAPN.VT.MS..NMMGPG.PG.GVGVGvgvgVGQVPPYA.RQQP.AGGGKP.........GVLSTQ
 2412- 2489 (117.50/34.25)	QQFQQQQQQQQLR.HQQmmQMQGMGGGG.GGGM..gaGPQQAS.GA..GVGGGG....GGMV.....QQQ........QSMNQQQTPNLVAQLqrqNMMGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.94|      26|     444|     966|     991|       2
---------------------------------------------------------------------------
  966-  991 (44.37/24.71)	SLLELCDNLLKELPEVEHQLQ..LKKSN
 1412- 1439 (38.56/20.54)	SLLEFAQAVLKQICAQEHVLErcLKNAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.26|      55|     445|     437|     499|       3
---------------------------------------------------------------------------
  437-  499 (78.57/82.75)	GGGENKLQHDPFELAlQEQMSCPHhrdiVLYLSTilQIITIECPTALgLDPLDHLPLA.PSVLP
  891-  946 (91.68/65.59)	GGKVKKHSRNEFNFE.ATTAKCQQ....MAYFDQ..HVVTAQCAANV.LEQLNGFALGnNNYLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.18|      10|     444|    1293|    1302|       4
---------------------------------------------------------------------------
 1293- 1302 (19.16/12.17)	IRLSCDRHLL
 1722- 1731 (19.03/12.04)	VDLSCNRELF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25065 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDLDKLVQNIKEKGQHDAPDSPKIGPPGDGEPSTGGAGGSI
2) GALGGGVSSGPGGPGGSSANSSTAVGAPVP
3) IEPVPEKICIKDEMMKADTPSSVDQSPSAVVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQPPNVQQQQQQMQQQQHMQQQQMQPNQMGMQMNMPMNMQQFAPNPNMMQQSALMQQQQQMQQMGTNQLQQQLNVGGGNGQQNPQMNFMQQGPGGGAAGPQGLPGQQQQQQWHNAPQQQQPPQQYHNHYAPHQQNMQSNRIERPPQNANSKQALSQMLRQRQPFQQQQQQQPGGGFNPMQQQQPQAQQQPGPQQQQMNPNQMRQQQMTAQQNPQSVAAFNAMQQQQQQNAQQQQQQMNPNQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGIPQNSMMQQQMTQGMVGMQGMMQQQAQQQPQQQLQFQNFQNQYQQQQQQHQQQGMQLHGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAAQQQQQQQQQRGVPGGMMAGNRGQYINQAPNVTMSNMMGPGPGGVGVGVGVGVGQVPPYARQQPAGGGKPGVLSTQQQFQQQQQQQQLRHQQMMQMQGMGGGGGGGMGAGPQQASGAGVGGGGGGMVQQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQHQPPPY
4) MLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAH
5) YQQTHDKASSNGSHSAGLTTASSGNSNGISVNSSGGNAAPPSATANVIPVPSMSSPLPPIHSPANGQPSTAGGVVGSGS
784
286
1891
1
202
825
315
2499
56
280










Molecular Recognition Features






MoRF SequenceStartStop




1) RYILL
851
855