<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25063

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVESKEFGKDSVFPQKVVLCSVSARNIIAFSSLQSAIVSHGPGDSNSAGVAVGASNSHVYVCDIVTPWEYYKVCSSKSLINVLEWSANGEKLLLGYVGGRVEIWQPKNQSINIWLLQYHANVPSEDIIEAKFFHNGKGVLFNPQKKEHTYYAEKFERLEQRPTLSGFGGVASEGCILLTSSGLLGSFSLPLFQKFSSAESAGNEIVELTPVMHSIGISRSFIEHCSMAPSPSGAVSVAFSCGWQQQLVQCFKISLMMEGDLGLEQHMAIKSESQASIFLNPLEGKLISHLKWTRVANDDVIFIAYSCTEGGSLLEQWTLTRRRQSVHALLQGGGSNKGNEFVQSESWEQVAKLHLNAPLADICLSRLMPSTAECSPVYAILQDNSVQVLEPNSLKQLNHTQFDKVTDGSGVKFVSGDLTPTSQMLLIFDAHAQLYAMQAPLLKQSGSALLLLEYCIVTGCDASDVLLLNLGNLEPLVEKLTDNFSRQPSYVKNYYYANFLALKSNLCRVQQQEFDNLIILHAISTTFKSLLRPSDLGYQDKGPADNLTTKLNESIPDVDTVMLNLDAKDFTVEPVMLQSLQQLIQWVTDLALNMLNMLPEEVMKCKLSGKRPSYDISRDINAISSLRELLVMIRIWGLLNTQCLPVYTKTMDNIDVLVILFRLLTRLAQNPAEPDEMLLDECSLLSKQLLIPQLNKFNPTTLLSAQGFAAVKSGHLMFTSLVEPKCLQDMEVENVVFAKSVKDGVSNLQLGAHPTTIRRCARCGFVFVNNANKVAKTSALKAWFNKWLHCHCGGFWKQIN
Length805
PositionTail
OrganismDrosophila persimilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.08
Grand average of hydropathy0.008
Instability index45.67
Isoelectric point6.17
Molecular weight89233.82
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
response to heat	GO:0009408	IEA:EnsemblMetazoa
response to lipopolysaccharide	GO:0032496	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.93|      52|     161|      35|      91|       1
---------------------------------------------------------------------------
   35-   91 (88.33/68.27)	FSSLQSA...IVSHGPgdsnsAGVAVGASNSHVYVCDIV.TPWEYYKV...CS.SKSLINVLEWS
  200-  259 (73.60/46.28)	FSSAESAgneIVELTP.....VMHSIGISRSFIEHCSMApSPSGAVSVafsCGwQQQLVQCFKIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     302.94|      72|     148|     577|     648|       2
---------------------------------------------------------------------------
  577-  648 (117.80/71.77)	VEPVMLQSLQ....Q......LIQWVTDLALNM.LNMLPEEVM..KCKLSGKRPSYDISRDINAISSLR.ELLVMIRIWGLLNTQC
  650-  726 (85.03/49.85)	..PVYTKTMD....NidvlviLFRLLTRLAQNP.AE..PDEMLldECSLLSKQLLIPQLNKFNPTTLLSaQGFAAVKSGHLMFTSL
  727-  797 (100.11/59.94)	VEPKCLQDMEvenvV......FAKSVKDGVSNLqLGAHPTTIR..RCARCG....FVFVNNANKVAKTS.ALKAWFNKW..LHCHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.95|      22|      74|     274|     295|       3
---------------------------------------------------------------------------
  274-  295 (38.03/25.94)	IKSESQ...ASIFLN.PLEGKLISHL
  347-  372 (30.92/19.63)	VQSESWeqvAKLHLNaPLADICLSRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25063 with Med16 domain of Kingdom Metazoa
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