<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25059

Description GL12308
SequenceMHGHHHNHQQQQQQQQQQQQQQQQQQGQQQQQQHQPQTGAGAVNNMKAASHHHPHVHPHPHPHPHPHPHHKLSSRRTARSRSRSRSPTPDGSQDYDVTRMREEDFERLAVYLVPDVQAERGLPNRADKTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNKARYFWRIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPERTIFGACKQASVEEDLEEDVEEELEDQDQDQDHDEMPPHKKPHYSMPAPEIPAEVAVSHITYVMGLHLPAAPGPQGATSAQEALPPAPPPTGSGSGACCRRASPPAHVSTTSCGGAHHPHIIQHGRHASVIIGQDRSPLASSSDKDTAGSPLSGLDHQLTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDCSKKAIAPKETVIAQAQKPQSTSPPTVGVTASIIHSPQAMAGMAATPMSCETDKNEYRKFKVKMPLKYEFKNKSCVKQEPIHKDVDEQMSHALPHGVDEEEELHAHLHANVAHSEDSACPPSTTTHLGDEHLLHLERERERERERERERERDREQSNQQPASSTVIVLEHNSDGQTRTIVPLSKPYYEADPPGERYVRFGQPSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQPQEQLSAAGVGVAEQELVTRGALIKGECSPPPPSHHHHNVIFSPSRHVSYMGQGEGGGHGGHSPSPSYPGYPHHYGSAATSTFHSPPHSSHSPFDRQSNASSGGGSASNLHLLQSSTQMLNHPLMQPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPCKPNNLEEELAMAAAATSECLDKDHPEPDSREAYEQLQQHMVHPSLRHSPPRLIPLGNHMQGPGQHQQQPPPPHMMLGPAPMLLTTASQLPPPPPHHLQQQQAQQGQQQPSPNQRPTPPHLHQHPHPHSHPHPHQQQQQHSPQAGSLKGLKPLPDNGGVYMHAPHVQAQENRPSVIESSNQPMIIECT
Length1218
PositionKinase
OrganismDrosophila persimilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.945
Instability index70.98
Isoelectric point6.77
Molecular weight135177.43
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:EnsemblMetazoa

GO - Biological Function
DNA-binding transcription repressor activity, RNA polymerase II-specific	GO:0001227	IEA:EnsemblMetazoa

GO - Biological Process
cellular response to ecdysone	GO:0071390	IEA:EnsemblMetazoa
pupation	GO:0035074	IEA:EnsemblMetazoa
regulation of tube architecture, open tracheal system	GO:0035152	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25059
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.75|      19|      19|    1085|    1103|       1
---------------------------------------------------------------------------
 1080- 1101 (36.71/11.07)	PP..rliPLGNHMQGPGQHQQQPP
 1148- 1171 (39.04/12.30)	PPhlhqhPHPHSHPHPHQQQQQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.91|      19|      19|     332|     350|       2
---------------------------------------------------------------------------
  332-  350 (28.88/ 9.69)	LPA.APGPQGATSAQEALPP
  351-  369 (35.62/14.20)	APP.PTGSGSGACCRRASPP
  802-  821 (27.40/ 8.70)	YPGyPHHYGSAATSTFHSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.92|      19|      22|     869|     887|       3
---------------------------------------------------------------------------
  869-  887 (37.04/15.87)	SPLRI..SPPSSLSP.DGNSCP
  932-  952 (21.28/ 6.25)	SNLKVhlRTHSGERPfKCNVC.
  988- 1009 (27.61/10.11)	SNLKThlRLHSGQKPyACDLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.80|      19|      22|     435|     453|       4
---------------------------------------------------------------------------
  435-  453 (38.33/19.84)	SD.EGYHSN..ECHEDGLTPPE
  456-  477 (24.47/10.01)	SDsESEHNYvlDCSKKAIAPKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.26|      18|      19|       4|      21|       5
---------------------------------------------------------------------------
    9-   24 (26.31/ 7.58)	QQQQQQQQQQQQQ....................qQQ
   25-   59 (27.48/ 8.25)	QQGQQQQQQHQPQtgagavnnmkaasHHhphvH.PH
 1131- 1154 (31.47/10.53)	QQAQQGQQQPSPN.......qrptppHL....H.QH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.46|      26|      54|     956|     981|       6
---------------------------------------------------------------------------
  910-  926 (19.82/ 6.15)	......LKK....KDGKMHYECNVCcK
  956-  981 (52.40/28.23)	FTQLAHLQKHHLVHTGEKPHQCDIC.K
 1012- 1032 (41.25/20.67)	FTQFVHLKLHKRLHTNDRP.....C.K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.98|      14|      19|     238|     255|       8
---------------------------------------------------------------------------
  238-  252 (24.46/17.03)	DILPnEELMVWYCKD
  260-  273 (26.52/18.71)	DVDP.ERTIFGACKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.17|      15|      19|     544|     558|       9
---------------------------------------------------------------------------
  544-  558 (26.26/15.41)	KQEPIHKDVDEQMSH
  566-  580 (24.91/14.20)	EEEELHAHLHANVAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.95|      24|     207|     619|     662|      11
---------------------------------------------------------------------------
  290-  313 (47.92/12.70)	DQDQDQDHDEMPPHKKPHYSMPAP
  636-  659 (44.03/14.45)	EHNSDGQTRTIVPLSKPYYEADPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.71|      16|      51|     717|     734|      12
---------------------------------------------------------------------------
  695-  712 (24.52/ 8.96)	RQANAAtpPPTSPTEMAY
  719-  734 (28.19/ 9.70)	RYGNAV..SPDSSSNLGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.14|      16|     763|     412|     430|      13
---------------------------------------------------------------------------
  412-  430 (20.47/21.06)	AGSpLSGLdhQLTPQDGSV
 1174- 1189 (30.67/16.19)	AGS.LKGL..KPLPDNGGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25059 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CVKQEPIHKDVDEQMSHALPHGVDEEEELHAHLHANVAHSEDSACPPSTTTHLGDEHLLHLERERERERERERERERDREQSNQQPASSTVIVLEHNSDGQTRTIVPLSKPYYEADPPGERYVRFGQPSSS
2) EDLEEDVEEELEDQDQDQDHDEMPPHKKPHYSMPAPE
3) LEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQPQEQLSAAGVGVAEQE
4) LHLPAAPGPQGATSAQEALPPAPPPTGSGSGACCRRASPPAHVSTTSCGGAHHPHIIQHGRHASVIIGQDRSPLASSSDKDTAGSPLSGLDHQLTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDC
5) MAAAATSECLDKDHPEPDSREAYEQLQQHMVHPSLRHSPPRLIPLGNHMQGPGQHQQQPPPPHMMLGPAPMLLTTASQLPPPPPHHLQQQQAQQGQQQPSPNQRPTPPHLHQHPHPHSHPHPHQQQQQHSPQAGSLKGLKPLPDNGGVYMHAPHVQAQENRPSVIESSNQPMIIECT
6) MHGHHHNHQQQQQQQQQQQQQQQQQQGQQQQQQHQPQTGAGAVNNMKAASHHHPHVHPHPHPHPHPHPHHKLSSRRTARSRSRSRSPTPDGSQDYDVTRMR
7) PKETVIAQAQKPQSTSPPTVGVTASIIHSPQAMAGMAATPMSCETDKNE
8) TRGALIKGECSPPPPSHHHHNVIFSPSRHVSYMGQGEGGGHGGHSPSPSYPGYPHHYGSAATSTFHSPPHSSHSPFDRQSNASSGGGSASNLHLLQSSTQMLNHPLMQPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLP
542
278
684
330
1042
1
475
753
672
314
750
468
1218
101
523
907










Molecular Recognition Features






MoRF SequenceStartStop




NANANA