<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25056

Description GL22502
SequenceMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITDEMQEALNGDRSKLPSLLSELRYWITHRRCEKTLQHLPATATDTLTFLTQPEQELLQQGRHKIYVKLHRHPNIILVVQLKEKSTMANEMEYTFHLGFVAFQKDEADVIDDSAKQLVSVVAQPPSDIPKFFTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSTGDILAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKSATAAGQQPQQGAASAAGAAAGAAASAGAGAAAGETKPQPPSGSSAFPRIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSCHPKEQSSRRTVYLTYEQANHDVSKTVEELLNDWSKIVYLYTLVYDFAEQLRNKRLALCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPMSSIAKLPVLPFLGIPRPQVPVLSFCMLAQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVIEEFTPIQGLKAFLSKYVDESAAYRGRAPHEDDNPLSPIGMEDNYGGPSSVTGVSAGGSSPFLGAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGAAQSHGNFNLTSPPAPHMPHPSPGGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNQWPGSPSMPRPSPRPGQSPEHKSTGGSVVTGGPDRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVTDMSPLERFLGCVYMRRQLHRNIQNEESLTALNSTEPGVVLFKVDGLQCQVMLNQMHMQTLHLKITQLPPPPDKPTFQLSPDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLELKPEFGGDQLKWTVQMCMRMPPSAVPIVPSGNACVVLGRMKILFFLQITKIPFNGKDWKDSPSLVLPIVYDITMNLTQMAERREQVPSPMMTAASTLLRRFSEFNSQQNQCSLFPAITDLLTNLQLATDMPQPPPNQAIGPPVGVGVGVGVGIGVVGSSPNPMMPMQQLQPQVGPQGQVGPGGYPQLGPNPGGPQ
Length1191
PositionTail
OrganismDrosophila persimilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.271
Instability index59.18
Isoelectric point8.47
Molecular weight130773.65
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25056
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     977.83|     319|     476|     237|     711|       1
---------------------------------------------------------------------------
  222-  683 (422.54/392.94)	FVATHGPGTEVDA..evSPHKRKSTGDILAPPAKQQKTIFPAyfiPELAHvvamcdekipfmnlaqtlskhniphsglqveanatslvlkilalPQPGK..SATAAGQQPQQGAASAAGAAAGAAASAGAG..AAAGETKPQPPsGSSAFPRIEPHVWDDLMRRVLSISV.....RSQTNKNSQVRIW..VVEFVFYSTPLQS.CHPKEQSsrrtvyltyeqaNHDVSKTveellnDWSKIVYLYTLVYdfaeqlrnkrlalcdmlvvksysyMNLLLGYGPKKEVSCNIYWSVQShGFRLTFVGGMsavNAHSMMrDQLaqHLnqqhsltqiaQILHetynpmSSIAKLPvlpflgiPRPQVPvlSFcMLAQSPCLMRLTYQAVYCLELRFRANRLVSIrdgassrfERnVIEefTPIQGLKAFLSKYVDEsaayrgRAPHEDDNPLS.PIGMEDNYgGPSSVTGVSAGGSSPFLG
  699- 1034 (555.29/282.73)	FPAPHTPPSSSNPhtpaSPHPSAGGGGAAQSHGNFNLTSPPA...PHMPH............................................PSPGGlmPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSpfTAMSPANNQWP.GSPSMPRPSPRPGQSPEHKSTGGSVvtggpDRGGSRGTLNRPWagAVPTLLTHEALETlCRPSPHP............NKDINVT......DMSPLERFLGCVY........................MRRQLHRNIQNEESLTALNSTEP.GVVLFKVDGL...QCQVML.NQM..HM..........QTLH......LKITQLP.......PPPDKP..TF.QLSPDDLLVIEQYFDTRVAAPPYRPNSLHSI........CR.LLN..LPAQVLKDFVQIMRLE......LKPEFGGDQLKwTVQMCMRM.PPSAVPIVPSGNACVVLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.40|      22|      27|    1127|    1150|       2
---------------------------------------------------------------------------
 1127- 1148 (45.27/16.61)	PQP.PPNQAIGPPVGVGVGVGVG
 1156- 1178 (41.13/15.89)	PNPmMPMQQLQPQVGPQGQVGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.41|      38|     960|      87|     125|       5
---------------------------------------------------------------------------
   87-  125 (64.64/46.45)	LNG.DRSKLPSLLSELRYWITH...RRCEKTLQhLPA...TATDTL
 1049- 1093 (54.77/33.84)	FNGkDWKDSPSLVLPIVYDITMnltQMAERREQ.VPSpmmTAASTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25056 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSSPNPMMPMQQLQPQVGPQGQVGPGGYPQLGPNPGGPQ
2) YRGRAPHEDDNPLSPIGMEDNYGGPSSVTGVSAGGSSPFLGAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGAAQSHGNFNLTSPPAPHMPHPSPGGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNQWPGSPSMPRPSPRPGQSPEHKSTGGSVVTGGPDRGGSRGTLNRPWAGAVP
1153
643
1191
843










Molecular Recognition Features






MoRF SequenceStartStop




NANANA