<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25047

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSHKPDNTDPNALTFEITTSTKVHPPLSLAAAKELWIFWYGEEPDLSDLVDAELLRVAARERDRARARHQIRTEPAERNQMRGPRRRPRRQRMRASYRANDPVAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHLEFAELQRASAGVGSGAEAAALSSASCPPAPSASASAATPPGASQAKDGGASRKAVPQAVSALERLSFQPYYDQRPTSGFSFNTHNTHIPAAAAVEMPERAWQDCVMNTLHVEAAAAAAAAAAAAAASAAAASGSAASATSGVPDEDEQNKPPADSKQLVQQQIQQQQQQQQQQQRQKLWNFVDPMQKAPCICTNAQCSSSKRQQQQQQQQFLSQQPLGSPSLRAAAGIVGGSSSKSSFQHHYQQQRPGTPAAAAAAAAAALAAAAAATHHSNNNNTTTTTTSSSSASTTNTTNTLNSNLNLNLNLNSNSNSSSSSAPRRHNVPFHKRLLNTLTQSSSSSAVVAARYKAATDTNTPKARHLCSTPHGTPHGGASTYSRNSLGGDSSLPVASVGSPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPSYTDHAAGGGASQSLTGPGSVPPQQQQQQPPTPTAGGTLTTSGANASAAGAASGTAGTPGGAASTTTTTTAQCGTISVKKLEMQQQTPAAHQIPIKPEPGTVRGTTVTSTTDAINNLLSLYKPPKLKLKDPDSFYDDEWLKEVIYDFQFQENWDYLTVKRPKMEETSKQKRTRSQLLSLDVQAAASGGAGGGGAAGSSSSGGLVGIVNSTANGSDAEAEGSSFFHGLDIKTEPGLHSPSCKETKSSSGGTTGASSGGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIDELKRSTAVASAVVAAAAAAAAVASSGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTSSAGAVIAAAAVAASASASVTTVSAVVALGTQSSLKLLKQEYNVELGSPLEEPIDDWNYVYRPPQQEKFVGSSRYAPLTNLPSQTLPSISMPTNCYYKPTWSTHKSRAATMAKVAAAQQQKHQKHQALQQCIQLHQQKLQQLQHQHQQQQQAAAASHAHQRHQQLHELLSAAPRTPQTAMPSPSTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPISPGPGGVGVPFPRNSPMLRQTPTHPPPPYPYDLGVASPATSTSSYLNRQLHSQEAQPHPHTPQSMHHIQSGMHGLGSGAGGAGHHHLGNMMPYTGDAGIASGPASAVAVPSGLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPAHSANAAATAGQRLLNGPSSSSSSAASFGGGLRMISAFGGSPASSSMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGKADDPGRNKQPSLLSLIQSLCRKNQAKAASGPGGDTSSSSALEKFMDAHDVISLALEQARMAFEHQRMDNMLEFHGNSSQQLTAFHAHPPALRQKLSILGSGCLTVHKWPYLPVGFTRSNKEIVRTMNSIQPMLQNAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVAGCTRSYFRELSSTYEICELERLALIALLRCYAELLKAVPDSVRAQMNIQIISLEAVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMYERTDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKVCINIDVPNRARRRKAPARYVALKKLMDFVMGIISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGELFWGDTHMDRVSNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEEVCPVFLKTALHLHVPNIQIADDILNSTNAHQSANDHPLDSSLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2374
PositionMiddle
OrganismDrosophila persimilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.450
Instability index52.73
Isoelectric point6.57
Molecular weight254442.01
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25047
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     203.79|      35|      35|     395|     429|       1
---------------------------------------------------------------------------
  395-  429 (65.61/35.07)	QQQQQQ...R...........QKLWNFVD.....P.MQKAPCICTNAQCSSSKRQ
  431-  463 (31.92/12.44)	QQQQQQflsQ...........QPLGS........PsLRAAAGIVGGSSSKSS...
  657-  679 (28.03/ 9.83)	SNLQQP...P...........TPIDHLLD.....K.NTPAPTP............
 1203- 1228 (38.95/17.17)	QQKHQK...H...........QAL.............QQ..CIQLHQQKLQQLQH
 1229- 1276 (39.27/17.38)	QHQQQQ...QaaaashahqrhQQLHELLSaaprtP.QTAMPSPSTVPQPLSS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      98.25|      17|     133|     341|     357|       2
---------------------------------------------------------------------------
  342-  358 (25.67/ 8.47)	AAAAAAAAAAASAAAAS
  746-  762 (26.96/ 9.29)	GANASAAGAASGTAGTP
 1087- 1103 (22.00/ 6.15)	AGAVIAAAAVAASASAS
 1531- 1547 (23.62/ 7.17)	PASSSMPGAGSGHGHGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.14|      20|      27|    1313|    1339|       3
---------------------------------------------------------------------------
  594-  613 (29.14/ 7.45)	PHGGASTYSRNS..L.....GGDSSLP
 1313- 1339 (32.99/22.14)	PGGVGVPFPRNSpmLrqtptHPPPPYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.59|      22|      27|     234|     258|       4
---------------------------------------------------------------------------
  234-  255 (37.39/14.66)	ASAGVGSGAEAAALSSAS...C........PPA
  260-  284 (35.23/18.62)	ASAATPPGASQAKDGGASrkaV........PQA
  709-  735 (23.97/ 7.52)	..AA.GGGASQSLTGPGS...VppqqqqqqPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.13|      34|     753|     617|     651|       6
---------------------------------------------------------------------------
  525-  547 (23.71/ 8.37)	........LNlNLN.........................L...NSNSNSSSSSA.......PRR.....H....N
  548-  579 (36.89/12.76)	VPFH.KRLLN..............................tltQSSSSSAVVAA.......RYKA....ATD.TN
  580-  638 (47.60/18.72)	TPKA.RHLCS.TPHgtphggastysrnslggdsslpvasV...GSPATPAPSPH.......PNSA....HSQPTS
 1342- 1365 (26.39/ 6.69)	............LG.........................V...ASPATSTSSYL.......NRQL....HSQEAQ
 1370- 1414 (28.54/ 8.11)	TPQSmHHIQS.GMH........................gL...GSGAGGA..GHhhlgnmmPYTGdagiASGPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.71|      23|      23|     884|     906|       7
---------------------------------------------------------------------------
  884-  906 (37.72/22.28)	VQAAASGGAGGGGAAGSSSSGGL
  910-  930 (35.09/20.00)	VNSTANG..SDAEAEGSSFFHGL
  940-  961 (33.90/18.96)	SPSCKETKSSSGGTTGASSGGG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.39|      18|      23|     299|     318|       9
---------------------------------------------------------------------------
  299-  318 (28.58/27.23)	QRPTSGFSFNThnTHIPAAA
  324-  341 (33.81/23.41)	ERAWQDCVMNT..LHVEAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.85|      20|      35|      26|      47|      10
---------------------------------------------------------------------------
   26-   47 (33.50/24.99)	LCGikWRKFVNGERPNASSDPL
   64-   83 (38.35/22.44)	LCV..WRRVQSHKPDNTDPNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.45|      13|     550|     479|     516|      11
---------------------------------------------------------------------------
  466-  478 (24.93/20.70)	HHYQQQRPGTP.........AA
  495-  516 (15.51/ 7.96)	HHSNNNNTTTTttssssastTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.86|      20|      23|     125|     144|      12
---------------------------------------------------------------------------
  125-  144 (32.80/21.73)	LRVAARERDRARARHQIRTE
  151-  170 (37.06/25.65)	MRGPRRRPRRQRMRASYRAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.28|      14|     550|     479|     492|      13
---------------------------------------------------------------------------
  479-  492 (22.68/10.69)	AAAAAAAALAAAAA
 1030- 1043 (23.60/11.42)	AAAAAAAAVASSGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.08|      43|     334|     770|     828|      14
---------------------------------------------------------------------------
  770-  828 (56.04/70.60)	TTTTA..QCGTISVKKLeMQQQTPAAHQIPIKpEPgtvrgttvtstTDAINnllSLYKPPK
 1105- 1149 (73.03/45.40)	TTVSAvvALGTQSSLKL.LKQEYNVELGSPLE.EP...........IDDWN...YVYRPPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25047 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEAAALSSASCPPAPSASASAATPPGASQAKDGGASRKAV
2) ARARHQIRTEPAERNQMRGPRRRPRRQRMRASYRA
3) ASAAAASGSAASATSGVPDEDEQNKPPADSKQLVQQQIQQQQQQQQQQQRQKLWN
4) ASSSMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGY
5) DRVSNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVE
6) GLHSPSCKETKSSSGGTTGASSGGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTN
7) KHQALQQCIQLHQQKLQQLQHQHQQQQQAAAASHAHQRHQQLHELLSAAPRTPQTAMPSPSTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPISPGPGGVGVPFPRNSPMLRQTPTHPPPPYPYDLGVASP
8) QAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMT
9) RQQQQQQQQFLSQQPLGSPSLRAAAGIVGGSSSKSSFQHHYQQQRPGTPAAAAAAAAAALAAAAAATHHSNNNNTTTTTTSSSSASTTNTTNTLNSNLNLNLNLNSNSNSSSSSAPRRHNVPFHKRLLNTLTQSSSSSAVVAARYKAATDTNTPKARHLCSTPHGTPHGGASTYSRNSLGGDSSLPVASVGSPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPSYTDHAAGGGASQSLTGPGSVPPQQQQQQPPTPTAGGTLTTSGANASAAGAASGTAGTPGGAASTTTTTTAQCGTISVKKLEMQQQTPAAHQIPIKPEPGTVRGTTVTS
10) TSTSSYLNRQLHSQEAQPHPHTPQSMHHIQSGMHGLGSGAGGAGHHHLGNMMPYTG
242
135
352
1532
2212
937
1208
1047
428
1349
281
169
406
1568
2246
1013
1347
1078
812
1404










Molecular Recognition Features






MoRF SequenceStartStop




1) FHKRLLNTL
550
558