<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25033

Description GL10594
SequenceMAHTQKPAPAPAAAQAAAAAAKAAAKSSAVSNSSKKLALSLKAPTTTTTAATATATATATNVTSTSADKMQMQMKQRQQKQQQQQQQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVFAVSSIKVKSENTLAAVTATVATPTTTTTNATPAATPAATAAATATVAAATVAAAKSMLEKNIKKESTPPATTPNVVESVEAASSSASCCSSSAWSTTTATSEDASSNGGASADEEAADTSDLAAPGNTELVTATTPRPVLLTAVNPHIICHLCQGYLINATTIVECLHSFCHSCLINHLRKDRFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYKDRPQEAALATPEQRGDDTEHLIFGPTDNMSLSLEYAELGELSTESEVEFLRPRYLQCPAMCRVSHLKKFVYDKFDIDVQRFSIDIMYKVKTIVLLDYYTLMDIAYIYTWKRDAPMRFYFRVYESPQRQVKPPPRRMLPAPLKVVKQEPTPAPEAPKVEQTSPTAAPVSPPASIKQELQEEIRVPSEPLKLIINRNMLEKREKSHSPQSSKSSAKSNHHTPTTPSSSSSSNSCPSPSGELNIKLKIDLSKHNSVTIINMSDPERKEIVKPLKPEKESRSKNRSKDKDKDGSPKSSSSSSERKRKSPSPLTVPPLTIRTERILSPSGVSTLSPRCVASSSCHEDPKSEFLKSFALTPIKVKVESPERSPSSHRAPTPPKTTASGSGSASHSHHSGRSKGTLEDRELMRPPAGMAPKSIASSKRKSKEPVKAVSKKPKLSPPLPREDFKIRLPATNSHSHPPPAPTTPPPFVGSLEKLMPPPPKPPMLASRKPQLAAQFAPPSPHHPGMQMAAPGNRTPIAKRYHPILPKAARPNPFANIPNDVNRLLKDAGTEIKSIGGSTSASSSKSHVYGPKADSKMGPPPPPAGAAATHAARHTSGGQGKTVGNNQPQPHPAPSSNGSQNKAANNYLNLALFNASKSKGREAPPGCRTPMYTPNSPIYSPSSPQYVPNYNIPTMPTYKYTPKPSQATAGGYLQSMLGGGGSGSGGGSLFPSPPTKADQNTNPAGAAPSSGHAFQRGASPSHEDAPEKQQVKVKSLLNSCNINIPSSLSITISRDNGDSSSASNGSHPKHKSPVNNYIEIVKLPDQPQDQGQKSAASVTEAQKRQSPPAPAPGRTPPPQLPAPPPSKAIPSPQHLMSRMTPPQLPQTAPPPSSSSTAPRGITPPKISPPASGKGTPLKTVLTPSQADSKKTPSPEKRSAAQMGSHSPTASENKSPKLAGQSAPGSATPNGDPAAKKFRPILPRQNAQIPDMAAKLPSLAPAFNFSQPQSQVQTGAKKVPTSKKSPNGGAAVFLPPPPKLPNGSHPAQKPSPPLKSQQTGGKKANKNPTPPPSSSAALGGGVQGNMGKLMPHPGLPGLNAPLSIASSAAAAAGQMDLNNFIKENLIRAQVAQAAQAAQAAQAAANQSNILYNFAQIGHMSPAMYNYQQAVFMEQLTRMQRAGNEAFNDYLQKLKNAANGQAGDGDHKPIMPMLPTVNLPSPSSATSAASPKTSALPNGKLTAAATAPSSHTPSSLAKAGSGASPRQQTAATPAAPLAAATKSK
Length1624
PositionKinase
OrganismDrosophila persimilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.689
Instability index65.69
Isoelectric point9.90
Molecular weight171927.26
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
polytene chromosome band	GO:0005704	IEA:EnsemblMetazoa
PRC1 complex	GO:0035102	IEA:EnsemblMetazoa

GO - Biological Function
chromatin binding	GO:0003682	IEA:EnsemblMetazoa
metal ion binding	GO:0046872	IEA:UniProtKB-KW
sequence-specific DNA binding	GO:0043565	IEA:EnsemblMetazoa

GO - Biological Process
chromatin remodeling	GO:0006338	IEA:EnsemblMetazoa
chromatin silencing	GO:0006342	IEA:EnsemblMetazoa
syncytial blastoderm mitotic cell cycle	GO:0035186	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25033
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.35|      15|      15|      89|     103|       1
---------------------------------------------------------------------------
   71-   85 (30.83/13.69)	QM.QMKQRQQKQQQQQ
   86-  101 (31.29/13.98)	QQkQQQQQQQQQQQQQ
  102-  117 (31.29/13.98)	QQqQQQQQQQQQQQQQ
  118-  131 (28.94/12.50)	QQ.QQQQQQQQQQQQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.95|      25|      31|    1349|    1379|       3
---------------------------------------------------------------------------
 1188- 1212 (39.69/ 7.12)	SPPAPAP.GRTPPP...............QLPAPPPSKAIP
 1366- 1406 (24.26/ 8.30)	SPNGGAAvFLPPPPklpngshpaqkpsppLKSQQTGGKKAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.41|      15|      18|     275|     292|       5
---------------------------------------------------------------------------
  275-  286 (18.58/ 9.48)	.....TAVN.PHIICHLC
  290-  307 (20.67/19.29)	LINatTIVEcLHSFCHSC
  308-  321 (27.16/14.11)	LIN..H.LR.KDRFCPRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.83|      13|      18|     147|     164|       9
---------------------------------------------------------------------------
   47-   59 (22.86/ 6.81)	TTTAAT......ATATATA
  159-  177 (15.97/10.17)	TTTNATpaatpaATAAATA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     214.69|      34|      35|    1059|    1092|      13
---------------------------------------------------------------------------
  500-  529 (42.17/12.16)	PAPL............KVVKQEPTPAPEAPKV...EQ.....TS.PTA.APV
  728-  753 (38.07/10.10)	..SP............SS.HR....APTPPKT...TA...SG.SGSASHSHH
  897-  930 (35.91/ 9.02)	ANIP............NDVNRLLKDAGTEIKS...IG...GSTSASSSKSHV
  941-  969 (33.67/ 7.89)	PPPP....................PAGAAATH...AArhtSGGQGKTVGNNQ
 1073- 1101 (32.68/ 7.40)	PSPP............TKADQNTNPAGAAPSSghaFQ...RGAS........
 1391- 1431 (32.19/ 7.15)	PSPPlksqqtggkkanK....NPTP...PPSSsaaLG...GGVQGNMGK.LM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     171.51|      34|      35|    1112|    1145|      16
---------------------------------------------------------------------------
  572-  600 (45.39/16.84)	KSSAKS..NHHT.PTT.....PSSSS...S.................SNSCPSPSGE
  602-  658 (29.47/ 8.63)	NIKLKIDLSKHNsVTIinmsdPERKEIVKPlkpekesrsknrskdkdKDGSPKSSSS
 1112- 1145 (55.05/21.82)	QVKVKSLLNSCN.INI.....PSSLSITIS.................RDNGDSSSAS
 1149- 1179 (41.60/14.88)	HPKHKSPVNNY..IEI..vklPD..Q...P.................QDQGQKSAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.52|      29|     159|      11|      46|      17
---------------------------------------------------------------------------
    7-   36 (43.64/12.84)	PAP.....aPAAAQA........AAAAAKAAAKSSAVSNSSKK
  156-  198 (36.88/ 8.87)	PTTtttnatPAATPAataaatatVAAATVAAAKSMLEKNIKKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.40|      22|     158|    1326|    1348|      19
---------------------------------------------------------------------------
  781-  801 (28.92/ 8.23)	SKRKSKEPVKAVSKK.PKLSPP
 1323- 1343 (31.70/12.98)	.LPRQNAQIPDMAAKLPSLAPA
 1345- 1361 (20.79/ 7.47)	NFSQPQSQVQTGAKKVP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.05|      12|     158|     530|     551|      20
---------------------------------------------------------------------------
  530-  551 (16.07/25.88)	SPPASIKqelqeeirvpSEPLK
 1249- 1260 (24.98/11.87)	SPPASGK..........GTPLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25033 with Med12 domain of Kingdom Metazoa
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