<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25013

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEVNVSCYCIWPEEKENGLTNGIHTRSNCLARHTVSSGWSNRNLLAFSASSKSKLEDSINSDFVSEHVSEIIQLAWDSHGTRLLSADSNGIIKTWQMQDNFINQWKCTSSNDLGEGEHVRAVRWLDTSAKEHYIDSKCKDKESFFEKFPYAVKKTPFVRYGGRPTQAWIAITATGMIYVTVLDPVTRGKLRLDLPSGYRLCISSADVTYNYQDSFVDQVRFLPQDAKSAPALLVLSSGYSQSTIQLFTLTTEPVLIHSAFNNPNLAERDIPVEEIWSCAAIYPCGEKVSCFSFSTFPIAPSSGDADYSKNANSHIMLACQKGNLILLNRSSLSIAACCNTPFGAVDDPLDWAFGSDRTVKSISFSPCGLCTAVINGRGDVAICRIRLSSSFDNSGSECFSCYVTLLEYCLTTGIEYWDILHSISATFGPSIDVVSKMIAYIKNDLSKQAQPLRESLQLRFAVMCAALYRYGSDEHGRFVDQRCRIILYCICKFLHFEILHKYQSKNTESNPILKLEDACNSDTDGNLAATVSRLEATEYVLNPGVIHHVRAMIDWIGNYALLLAATVSAREIIQEAYGVTDMEVVRNLRMLLLLVSTWGQGNAAFYPRFYPQSDPVPSLSTIYRILTKVWMCYKNDNKLDSIIQYLSDKDQLPSLQSLMDTRGAFLCISDRLLLGPNIAFFRFGENPSTEPNMRYDVIRLMAINPFYNENLRQCVRCGGLSMITMNSSIDDNYNWNSRWIAKCICGGSWFKL
Length752
PositionTail
OrganismTrichoplax adhaerens (Trichoplax reptans)
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax.
Aromaticity0.10
Grand average of hydropathy-0.108
Instability index39.91
Isoelectric point6.10
Molecular weight84417.30
Publications
PubMed=18719581

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25013
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.41|      12|      27|     707|     719|       1
---------------------------------------------------------------------------
  707-  719 (22.67/17.43)	YNENLR...QCVrCGG
  733-  747 (23.73/13.04)	YNWNSRwiaKCI.CGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.34|      18|      77|     395|     421|       2
---------------------------------------------------------------------------
  401-  421 (27.25/28.62)	CYVTLleYCLTTGIEYwDILH
  483-  500 (37.09/12.92)	CRIIL..YCICKFLHF.EILH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.40|      14|      33|     522|     535|       4
---------------------------------------------------------------------------
  522-  535 (25.72/16.04)	DTDGN....LAATVSRLE
  554-  571 (21.69/12.50)	DWIGNyallLAATVSARE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.99|      20|      31|      95|     115|       5
---------------------------------------------------------------------------
   95-  115 (33.26/25.08)	W...QMQDNFINQwKCTSSNDLGE
  124-  146 (31.73/17.66)	WldtSAKEHYIDS.KCKDKESFFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.06|      23|      31|     156|     178|       6
---------------------------------------------------------------------------
  156-  178 (43.17/27.32)	PFVRYGGR...PTQAWIAITATGMIY
  184-  209 (35.89/21.54)	PVTRGKLRldlPSGYRLCISSADVTY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25013 with Med16 domain of Kingdom Metazoa
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