<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25013
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MEVNVSCYCIWPEEKENGLTNGIHTRSNCLARHTVSSGWSNRNLLAFSASSKSKLEDSINSDFVSEHVSEIIQLAWDSHGTRLLSADSNGIIKTWQMQDNFINQWKCTSSNDLGEGEHVRAVRWLDTSAKEHYIDSKCKDKESFFEKFPYAVKKTPFVRYGGRPTQAWIAITATGMIYVTVLDPVTRGKLRLDLPSGYRLCISSADVTYNYQDSFVDQVRFLPQDAKSAPALLVLSSGYSQSTIQLFTLTTEPVLIHSAFNNPNLAERDIPVEEIWSCAAIYPCGEKVSCFSFSTFPIAPSSGDADYSKNANSHIMLACQKGNLILLNRSSLSIAACCNTPFGAVDDPLDWAFGSDRTVKSISFSPCGLCTAVINGRGDVAICRIRLSSSFDNSGSECFSCYVTLLEYCLTTGIEYWDILHSISATFGPSIDVVSKMIAYIKNDLSKQAQPLRESLQLRFAVMCAALYRYGSDEHGRFVDQRCRIILYCICKFLHFEILHKYQSKNTESNPILKLEDACNSDTDGNLAATVSRLEATEYVLNPGVIHHVRAMIDWIGNYALLLAATVSAREIIQEAYGVTDMEVVRNLRMLLLLVSTWGQGNAAFYPRFYPQSDPVPSLSTIYRILTKVWMCYKNDNKLDSIIQYLSDKDQLPSLQSLMDTRGAFLCISDRLLLGPNIAFFRFGENPSTEPNMRYDVIRLMAINPFYNENLRQCVRCGGLSMITMNSSIDDNYNWNSRWIAKCICGGSWFKL |
Length | 752 |
Position | Tail |
Organism | Trichoplax adhaerens (Trichoplax reptans) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.108 |
Instability index | 39.91 |
Isoelectric point | 6.10 |
Molecular weight | 84417.30 |
Publications | PubMed=18719581
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | |
GO - Biological Process | positive regulation of transcription, DNA-templated GO:0045893 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP25013
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.41| 12| 27| 707| 719| 1
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707- 719 (22.67/17.43) YNENLR...QCVrCGG
733- 747 (23.73/13.04) YNWNSRwiaKCI.CGG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.34| 18| 77| 395| 421| 2
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401- 421 (27.25/28.62) CYVTLleYCLTTGIEYwDILH
483- 500 (37.09/12.92) CRIIL..YCICKFLHF.EILH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.40| 14| 33| 522| 535| 4
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522- 535 (25.72/16.04) DTDGN....LAATVSRLE
554- 571 (21.69/12.50) DWIGNyallLAATVSARE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.99| 20| 31| 95| 115| 5
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95- 115 (33.26/25.08) W...QMQDNFINQwKCTSSNDLGE
124- 146 (31.73/17.66) WldtSAKEHYIDS.KCKDKESFFE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.06| 23| 31| 156| 178| 6
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156- 178 (43.17/27.32) PFVRYGGR...PTQAWIAITATGMIY
184- 209 (35.89/21.54) PVTRGKLRldlPSGYRLCISSADVTY
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