Description | Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MNGSNNYRQSQEDWHSSEFRQHVINQIMEAMRNSCNPTTKSAREMEAHIFGNADCKERYLNLVARLILHMKDNRKSDGPGTRRTSQTAPMLSQAFAQNQCNPTGNQTVPPVSRPNIQASVGGGANVNNPPALLTSALLSSSSNGPQPPTSISSQGQGLGYSQVSIASANAYCQQGQGTNQSQYPHQVQPNPSPCSQTVAFPNPSPYSQQPIMKSPHSSQPSQSPYALQQPIKSPHSNQSAQFAYVQQPIKSPHTQPQVGPSAYVQQQAIRSPHPSPQVNSGKGHHSQAHQQIIKSPLTTGHPANSYQQQQPSLKSPAHPQSVINNRSPYPAQNIKSPVQQPPMLNNRSPYPQPSIKSPYPQSQPQQQQSSKSPFYPQIVQAPTKSPLLAPSPVTNVTTPNSVTVSQSPATNANPGSVGSVGGSVPASSPLQSVNPSDDAAYMEKLRDLTKYIAPLRRLIDRTTKEGRKKEIHKMKSLLEILANPQKRVPLATLTKCESVLEKLQASFSPQSQPPSVAIGTTTNGIAATNTNGVTSIATTTSNSSSNTIVSTTSVGSAPVTTSSGLAPSQDVCKPLIDIIAANLNSPALAYALQQTCGPAFTTMRGPMTPLTEQTVKRKRIKYSDSKMRSEQENVIETEMTELDDLFVIEKNVHPLMDSESFLLKCSIDDASLPPVPSIYVIIPEDYPYSSAQCQTTTVEYRANPFFVTIIEDLSSRLLKMPRVTLTGILNAWVIKLSILKAYSKDEHEFENLHQQNSFIPESISSGLA |
Length | 768 |
Position | Tail |
Organism | Trichoplax adhaerens (Trichoplax reptans) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.583 |
Instability index | 69.29 |
Isoelectric point | 9.20 |
Molecular weight | 83268.48 |
Publications | PubMed=18719581 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25010 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.11| 17| 18| 201| 217| 1 --------------------------------------------------------------------------- 190- 211 (30.75/ 9.49) NPSPCSqtvafPNPSPYS.QQPI 212- 231 (26.36/ 7.05) MKSPHS...sqPSQSPYAlQQPI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 130.76| 16| 18| 243| 258| 2 --------------------------------------------------------------------------- 243- 258 (34.78/16.60) AYV.QQPIKSPH..TQPQV 262- 278 (25.25/ 9.51) AYVqQQAIRSPH..PSPQV 287- 302 (21.66/ 6.85) QAH.QQIIKSPL..TTGHP 328- 343 (27.61/11.27) PYP.AQNIKSPV..QQPPM 349- 365 (21.46/ 6.70) PYP.QPSIKSPYpqSQPQ. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.54| 19| 20| 520| 538| 4 --------------------------------------------------------------------------- 520- 538 (30.46/21.16) TTTNGIAATNTNGVTSIAT 543- 561 (30.08/20.79) SSSNTIVSTTSVGSAPVTT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 223.68| 65| 159| 454| 518| 7 --------------------------------------------------------------------------- 454- 518 (109.49/65.52) PLRRLIDRTTKEGR.KKEIHKMKS...............LLEILANPQKRV.PLA.TLTK.CESVLEKLQASFSPQSQPPSVAI 562- 604 (37.21/17.17) ..........SSGL.APSQDVCKP...............LIDIIAANLNSP.ALAyALQQtCGPAFTTMR.............. 606- 678 (76.98/43.77) PMTPLTEQTVKRKRiKYSDSKMRSeqenvietemtelddLFVI....EKNVhP....LMD.SESFL..LKCSIDDASLPPVPSI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 42.15| 11| 41| 382| 392| 8 --------------------------------------------------------------------------- 382- 392 (21.25/ 8.56) PTKSPLLAPSP 425- 435 (20.90/ 8.30) PASSPLQSVNP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 101.74| 26| 72| 25| 53| 9 --------------------------------------------------------------------------- 28- 53 (48.10/30.73) MEAMRNSCNPTTK......SARE...MEAHIFGNA 70- 95 (26.88/ 8.10) MKDNRKSDGPGTR......RTSQtapMLSQAF... 97- 124 (26.76/10.87) ....QNQCNPTGNqtvppvSRPN...IQASVGGGA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.55| 14| 56| 308| 322| 10 --------------------------------------------------------------------------- 308- 322 (24.75/16.04) QQQPSlKSPAHPQSV 366- 379 (28.79/14.56) QQQSS.KSPFYPQIV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IIKSPL 2) PFYPQIV | 292 373 | 297 379 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab