<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25003
Description |
Mediator of RNA polymerase II transcription subunit 6 (Fragment) |
Sequence | LQISWQDSNWIPNLTPDNVLDYFSQRSNPFYDRTCNNEVIKMQRLEASRLKSLTGIEYDLIHVQDPILYIIRKQHRHSPTEVTPLAEYYVLAGVVYQAPDLASVLNSRLLSALYHIQSAYNEAMSYSRFEAGKDYYWEFEKKGITSPRRPSSSNRHELSSTLFQRKKVDAVLTDFSKKFPPKHIK |
Length | 185 |
Position | Head |
Organism | Trichoplax adhaerens (Trichoplax reptans) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax.
|
Aromaticity | 0.12 |
Grand average of hydropathy | -0.585 |
Instability index | 54.97 |
Isoelectric point | 9.06 |
Molecular weight | 21618.22 |
Publications | PubMed=18719581
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coactivator activity GO:0003713 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP25003
No repeats found
|