Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAENDSDIDSLKTLQQQIEQLCETSRQVGIIASDFQATSQKVLNDKLRGLITNLREINDMKEKFDDIEVPLEVFSYIDEGRNPELYTKACLDKVVMMNQEMKGKVDAYKNFKTTLCEGLAKVFPKEMEAYLEYRDSQ |
Length | 137 |
Position | Middle |
Organism | Trichoplax adhaerens (Trichoplax reptans) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.580 |
Instability index | 33.43 |
Isoelectric point | 4.64 |
Molecular weight | 15814.82 |
Publications | PubMed=18719581 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | chromatin GO:0000785 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP25002 No repeats found |
MoRF Sequence | Start | Stop |
1) KFDDIEVPLEVFSYI 2) LAKVFPKEMEAYLEYRD 3) QKVLNDKLRGLITNLREINDM | 63 119 40 | 77 135 60 |
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