<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24995

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDTNPIVNGSHGKQKIKLSTLMDFIIQKAYHDLNVLTEILPRKGDVERKIAIYRYSASMRQQFVRLLAIVKWATKAEKIEKCFQLCDFLEQEGKIFVDTADELYRIANEMLPQAKLPYFDLISAAEVLSRGSYSLLPTCIKDKIIPLPPMTRDDKKTTLQKLNEVIKDRLLRSNVPQGISKTVIGNGQLTLTVEGEFEVVLTLLGDDPALPWRLLSIKILIEEADIGDYLCLSLQLEVLHSQAENLVAHRWAGYVKLIDHLPGGKLILSYWRKKEIQDQLTLSEDRVDYTLTVYIDQEKNDTPLSVEHFPVQEELNTSLNKLDLKKRGGLSIETLLMEAIEKRSLSKLMEVKHALQSSGLNLPVKLERDRIPSLVVNLIDDDDSSERLLLSVDTKSGDTKAMFSSDLSLIDENVNVNKLCNIIADAKIEAHLRICLQALAPLPVTCNRRLPIHCDSFDLLDKISKHRLFVKLHDLDQYYLIIGVECSKDLNVKESFYLMNVNDSTLGNSSEDVAFHCASFIKIRDVKSCQISDSEYHLMNVTEGVKNSPSKKRKFEAAFGLSVGSTKHIKFARTRVVDMIHFTLSTVAHAQLCKGLQRANFLYEKIYKDIHGDNVLKILWPPKFPDLCSPIIMDSILKNLIDFRVRLVDDGFQWKWLAEVTFKNHPVTALKASKSIEEEHIRFIVSYDTNHKWNPSTGDISLKLLDDWKGIIILYRLTSDLAEALQGNISIVICTVLDFMVRISWCDKMFKLRFSSISNANANFGENPHNLILDHLQHKLNNSKDIVKLLEKLSTAALAFTVLPLSCDHLRIQFRHFFIMDVHLKNSNSVIIHDMGKNTEVAVIPGFKEFITKFIETVDTSMAFTNDISESNIMDTEDTYPNRPNSADNSHADATLAIEALKEMTSTVESPTLPFSTSPFISGHNSSPLFIFSTSDFIQADNSPSGRRIGENHSSPQASVPNQLAAIVSGNENQTFTGNYLNNPPTKLQKQEYWASLSKVSTLTSARSDSVEISQAAFAKLLEPVSTDESLSGCLLSPFERYLSCAFLLQQIKRSAKSCDVSVGNETSRIVNLRFSMDNMSAEAMIDVSHLPTLRLGLLSSRDNFMKEDDVRTLVEFFRLKVASYPYKAGSLSSFLTLITAPVKILEDCINIMKLELFPDPKRSWKVCWCLTIPPNCPKIAPLGFQAVALKAKLLIVLQFWKYGVTPLVIPIVCSVQDGSVNVLDSVYPDGVDSNLLSAVKSILKSRKDVYPSSRDRCQLFETVREILAKL
Length1271
PositionTail
OrganismTrichoplax adhaerens (Trichoplax reptans)
KingdomMetazoa
LineageEukaryota> Metazoa> Placozoa> Trichoplacidae> Trichoplax.
Aromaticity0.08
Grand average of hydropathy-0.100
Instability index37.74
Isoelectric point6.48
Molecular weight143179.63
Publications
PubMed=18719581

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24995
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.28|      39|     109|    1048|    1086|       2
---------------------------------------------------------------------------
 1048- 1086 (65.11/45.93)	LLQQIKRSAKSC.DVSVGNETSRIVNLRFSMDNMSAEAMI
 1157- 1196 (67.17/47.64)	LFPDPKRSWKVCwCLTIPPNCPKIAPLGFQAVALKAKLLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.77|      57|      63|     854|     913|       3
---------------------------------------------------------------------------
  854-  913 (85.27/74.47)	FIETVDTSMAFTndISESNIMDTEDTYPNRPNSADNSHADATLAiEALKEMTSTVESPTL
  920-  976 (97.50/72.36)	FISGHNSSPLFI..FSTSDFIQADNSPSGRRIGENHSSPQASVP.NQLAAIVSGNENQTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.11|      41|      61|     453|     498|       4
---------------------------------------------------------------------------
  453-  498 (62.80/69.64)	HCDSFDLLDKISKhrlfVKLHDlDQYYLII...GVE..CSKDLNVKESFYL
  516-  561 (63.31/51.19)	HCASFIKIRDVKS....CQISD.SEYHLMNvteGVKnsPSKKRKFEAAFGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.52|      27|      63|       6|      32|       5
---------------------------------------------------------------------------
    6-   32 (48.12/37.42)	IVNGSHGKQKI.KLSTLMDFIIQ..KAYHD
   69-   98 (40.40/30.03)	IVKWATKAEKIeKCFQLCDFLEQegKIFVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      18|      23|    1227|    1244|       6
---------------------------------------------------------------------------
 1227- 1244 (30.98/20.83)	VYPDGVD.SNLLSAVKSIL
 1250- 1268 (28.94/18.94)	VYPSSRDrCQLFETVREIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.39|      10|     119|     215|     224|       7
---------------------------------------------------------------------------
  215-  224 (14.60/ 8.49)	LSIKILIEEA
  234-  243 (15.79/ 9.80)	LQLEVLHSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.42|      24|     112|     295|     322|      11
---------------------------------------------------------------------------
  299-  322 (40.74/33.32)	KNDTPLSVEHFPVQEELNTSLNKL
  325-  348 (37.68/19.74)	KKRGGLSIETLLMEAIEKRSLSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      15|      63|     131|     149|      12
---------------------------------------------------------------------------
  131-  145 (25.84/25.58)	GSYSLLPTCIKDKII
  157-  171 (23.05/ 8.43)	TTLQKLNEVIKDRLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24995 with Med14 domain of Kingdom Metazoa
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