<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24984

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADQDWQSQKFRQNVISKIHELLPPNAQDQTKNASVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQLQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQVMPMGAGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMPNIRGQMPVGGAQQMMQQQMQGGNNPGVMNVMGAGGAPNQGQIVGNAGQQMGGMPNQMVGPGPNSGPAVVGAGGANTAPGAAGPVPNQMQNNPINVNAMQPMPPMQQIQQNQMAMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPPNMQQGQHNVVGGPAGQQQVGGAGLPPNAVQQGGINPMGGMGVNMPPNLQQKPNMAMGQGGQMFPGNRGGIGVGGQQPGQPFMRSSPSPADAQQLQQQQQQVQLQQMQQQQQQQLGVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMQMQNPQRNIRQQSPSASINTPGQVTGNSPFNPQEEAMYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALERMDLISYSGQQFGKSSNPLLEVINTTLQSPVANHTLHRTFRPTLELLFGTDIAAPVPAKRPRIEEKSSPFEQDVPHVLQGEIARLDTKFKIKLDTTSQVNNKAIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLTEQEYSATPFLQTVQQALTARMSKLPKNYSLSHLLDTWEMAVRQACSPHSKPRDVCELTTLMGM
Length751
PositionTail
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.699
Instability index65.42
Isoelectric point9.35
Molecular weight81491.25
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24984
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     281.96|      48|      50|     177|     226|       1
---------------------------------------------------------------------------
  104-  166 (48.44/ 7.19)	AlqnlasqGNrNPQVMP.MGAGGAPVPGG.PGTASnllqslnqqrpgqQQMQPMPNirgQM....P......VgG
  177-  226 (97.51/24.41)	G.......GN.NPGVMNVMGAGGAPNQGQIVGNAG.............QQMGGMPN...QMVGPGPNSGPavV.G
  332-  371 (72.53/14.63)	G.......GI.NP..MGGMGVNMPPNLQQKPNMAM.............GQ.GG......QMF.PG.NRGG..I.G
  373-  421 (63.48/11.59)	G.......GQ.QPG.QPFMRSSPSPADAQQLQQQQ........qqvqlQQMQQQQQ...QQLGVG.NQTP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.52|      37|      40|     254|     293|       2
---------------------------------------------------------------------------
  228-  254 (41.11/ 8.00)	GGANTAPGA.AGPVP..NQMQNN..PINVNAM.........
  255-  284 (40.57/13.99)	...........QPMPPmQQIQQNqmAMGMNPMMRMGQGNGM
  285-  310 (47.83/10.64)	GGPQGMPGQgMQGMPP......N.........MQQGQHNVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      24|      29|     424|     447|       3
---------------------------------------------------------------------------
  424-  447 (46.66/16.54)	QPPTPQMPTPQMIPSPALVPQSSP
  456-  479 (40.96/13.68)	QRNIRQQSPSASINTPGQVTGNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.95|      21|      25|     691|     715|       4
---------------------------------------------------------------------------
  692-  714 (29.13/32.45)	YSATPFLQT....VQQALTARmSKlPK
  716-  740 (34.82/25.41)	YSLSHLLDTwemaVRQACSPH.SK.PR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.50|      23|      44|     600|     626|       7
---------------------------------------------------------------------------
  612-  653 (22.27/18.20)	IEEKSSPfeqDVPHVlqgeiarldtkfkiklDTTSQVNNKAI
  659-  683 (37.23/16.35)	LDDKRLP...SVPPV..............svSVPEEYPWQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.20|      14|      27|     567|     580|       9
---------------------------------------------------------------------------
  567-  580 (24.34/13.11)	PLLEVI.NTTLQSPV
  591-  605 (19.86/ 9.56)	PTLELLfGTDIAAPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24984 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KDMSRKSQQLQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQVMPMGAGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMPNIRGQMPVGGAQQMMQQQMQGGNNPGVMNVMGAGGAPNQGQIVGNAGQQMGGMPNQMVGPGPNSGPAVVGAGGANTAPGAAGPVPNQMQNNPINVNAMQPMPPMQQIQQNQMAMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPPNMQQGQHNVVGGPAGQQQVGGAGLPPNAVQQGGINPMGGMGVNMPPNLQQKPNMAMGQGGQMFPGNRGGIGVGGQQPGQPFMRSSPSPADAQQLQQQQQQVQLQQMQQQQQQQLGVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMQMQNPQRNIRQQSPSASINTPGQVTGNSPFNPQEEAMYREKY
2) QNVISKIHELLPPNAQDQTKNASVMENHIFR
63
13
492
43










Molecular Recognition Features






MoRF SequenceStartStop




NANANA