<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24978

Description Uncharacterized protein
SequenceMDHNMQHAPLHHWGYAAGPAMSMAGGPGTPQSHWVPPPQSHQSHHSNHSSHSLSHGHNSLKRALSESDCDELYSEESSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKNLQSKTLDSLSYDPQRVAMDYHSIGFRECAAEVARYLVTIEGMEIQDPLRLRLMSHLQYFVQQRELSAKTCGSPGGWAPSTPSSAGYQPNCAATPYQSYPSNPGSYVSSYPTLSASPSHQPPMAVGRTSVSRTSGAGVEAISSHDLHVEASSQQQQQQQQQQQQQQQQQQQQQQQQQQHSRTQTTPIPAQQQHYTHDHSAVHPEPQQQIPTYIDLTNSHRPAAVGADSLSYSSAPQYPVSGGQDYNNSSVLQYATPNGAKPYRPWGAEMAY
Length418
PositionKinase
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.939
Instability index75.75
Isoelectric point7.12
Molecular weight46327.42
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:EnsemblMetazoa

GO - Biological Function
DNA binding	GO:0003677	IEA:InterPro
protein dimerization activity	GO:0046983	IEA:InterPro

GO - Biological Process
neuron fate determination	GO:0048664	IEA:EnsemblMetazoa
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.13|      14|      15|     300|     313|       1
---------------------------------------------------------------------------
  300-  313 (29.08/ 9.46)	QQQQQQQQQQQQQQ
  317-  330 (29.05/ 9.44)	QQQQQQQQQHSRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.36|      19|      20|     218|     236|       2
---------------------------------------------------------------------------
  218-  236 (41.59/21.93)	C.GSPGGWAPSTPSS..AGY.........QP
  238-  268 (23.77/ 9.15)	CaATPYQSYPSNPGSyvSSYptlsaspshQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.33|      14|      15|     379|     392|       3
---------------------------------------------------------------------------
  379-  392 (26.22/14.39)	SSAPQYPVS.GGQDY
  395-  409 (18.11/ 7.43)	SSVLQYATPnGAKPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.88|      14|      15|     335|     349|       4
---------------------------------------------------------------------------
  335-  349 (25.04/16.61)	PaQQQHYTH.DHSAVH
  352-  366 (23.83/11.02)	P.QQQIPTYiDLTNSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.69|      15|      16|      19|      33|       6
---------------------------------------------------------------------------
   19-   33 (29.19/13.68)	PAMSMAGGPGTPQSH
   37-   51 (29.50/13.90)	PPQSHQSHHSNHSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.60|      10|      32|     160|     169|       7
---------------------------------------------------------------------------
  160-  169 (18.87/11.67)	DPQRVAMDYH
  194-  203 (16.73/ 9.58)	DPLRLRLMSH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24978 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CGSPGGWAPSTPSSAGYQPNCAATPYQSYPSNPGSYVSSYPTLSASPSHQPPMAVGRTSVSRTSGAGVEAISSHDLHVEASSQQQQQQQQQQQQQQQQQQQQQQQQQQHSRTQTTPIPAQQQHYTHDHSAVHPEPQQQIPTYIDLTNSHRPAAVGADSLSYSSAPQYPVSGGQDYNNSSVLQYATPNGAKPYRPWGAEMA
2) MDHNMQHAPLHHWGYAAGPAMSMAGGPGTPQSHWVPPPQSHQSHHSNHSSHSLSHGHNSLKRALSESDCDELYSEESSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDR
218
1
417
109










Molecular Recognition Features






MoRF SequenceStartStop




1) AEMAY
2) KPYRPW
414
407
418
412