<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24972

Description "Uncharacterized protein, isoform A"
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHNSNVNAGKVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQSHDKNNSNSSNQPSITAPGSVGGTNGTSSSGPGSTTSSSAPSNVIPVPSMASPLPPIHSPANGQQGSVGPGVGSGSGLPPTVGLGGSAPGSSVVGGAAGVGAAVPPGSSISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVAKKLAQLLNTAVEQQGIKELDDHRMQQDPYELALQEQMSCPHHRDVVLYLSSILQIITIECPTALVWSGIPAHRATSVLVGSPLDHLPLAPSVLPMPTRCPRTNLEIRRQLRAAEADIVLRTQHAEQRWFASKWLNAGKNQYTGVLATLDHLDTHCFDRLDQGNSIDTLYAHIFPSTSRRRDEDQQEQQQQPRPAYEPKQDKDTVRILCEWAVSGQRWGEHRAMVVASLLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHSGSSQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVNKSGTTATKTSPPPPAPPPTTTHGFDDDGFGGGIDFKHNEFDDSNVDEDLDKLVQNIKEKGQQHEAPDSPKIGPPGDNDTSTGGTGTISRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMAKEIGKLFTKKFSIDVAAAGHVKKHSRNEFNFEATTAKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIISILRRYHSCLLLSPEQTLSVFEGVCRTIRHVSNPSECSSAERCILAYLSDLHESCVLLQGKEQSAEYYQQLQCIKRFKDIFNTPEQLSLPPQGYNPQLLQELFVAPRRGGKLEPHWLRTLHESPANVYSFVSNAVITVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGQGGQVDIGQTKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSSGGAELSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGNDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLTAGGSSSGGLGGAFGSGRRSGFSTPVHPGSTPKSNEQRPADLSQILGTSDLQMGSSLTSEPETMQQPSSGGGLEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLCDMIMDEMLTAKQAQRVLHMICYPEAEFNIISELDQKAMIVRILENLGQWTLRISWLDLQLMYRQSLSNNAELNVWLDTVARAAIDVFHMEEVVLPGALKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGAAPRNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFSELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLLDSQSDRDDKKNYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGVDTKGNKICDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKFERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVQEKISIKDEMKADTPSSVDQSPSAPVGGTGRGRGKGTTTRKRKPKNPKTPPVNNQTQQPQLAPQPQQPPNVQQQQQMQQQQQQQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNANNMMQQNAMMQQQQMQQMGGNPLQQQLNVGGGNGQQNPQMNFMQQGPGGGGGAPQGMPGQQQPQQWHNNPQQQQPPQQYHNQYAPHQQNMQSNRIERPPLNANSKQALSQMLRQRHPFQQQQQQQQGPAGGFNPMQQQPQAQQQQPGPQQQMNPNQMRQQQMNTQQNPQALAAFNALQQQNAQQQQMNPNQQQQQQFMRGNMRPGMTPNQMNQMNMGGQGMPQNPMMQQQMQQGMVGMVNPNGNQMMQTGGGQGGNGVGVGVGVGVGVGVGAGGNNPNMGMGGMSQQGMMQQQPQQQPQQQVQFQNFQNQYQQQQQQQGMQQQGGAGVGVGVGVGMAPNQQQQGNMMGNFNPQMQQANRNNPDFMTAAAVAQQQQQQQQRGVPGGMMAGNRGQYMNQAPNVTMSNMMGPGPGQVPPYARQQAAGGGKPGVLNTQQQFQQQQQQQLRHQQMMQMQGMGGGGGGGMGAGPQQAGGAGGVGGGGGGVGVGVGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQPPPY
Length2538
PositionKinase
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.566
Instability index53.89
Isoelectric point7.87
Molecular weight279723.56
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     756.41|      63|      63|    2231|    2293|       1
---------------------------------------------------------------------------
 1985- 2016 (46.81/10.39)	QQQMQ.PNQMG.......................................qmPM....NmPMNMQQ................F.........APN........ANNMMQ
 2040- 2102 (92.87/27.73)	VGGGNGQQNPQMNF.......MQQGPGGGGGAP...Q..GM....PgqQQ..PQqwhnN.P.QQQQ................PPQQ.YHNQYAPH.........QQNMQ
 2103- 2147 (55.31/13.59)	SNRIERP...............P..LNANSKQA...L.SQMlrqrH..PF..QQ.........QQQ................QQQG.PAGGFNP.............MQ
 2148- 2205 (68.30/18.48)	QQPQAQQQQPG...............PQQQMNP............N..QM..RQ....Q.QMNTQQnpqalaafnalqqqnaQQQQ.M....NPN........QQQ..Q
 2206- 2259 (102.95/31.53)	QQFMRGNMRPGMTPNQ....M.........NQM...N.MGG....Q..GM..PQ....N.PMMQQQ................MQQG.MVGMVNPN........GNQMMQ
 2260- 2324 (103.77/31.83)	TGGGQGGNGVGVGVGV....GVGVGVGAGGNNP...N.MGM....G..GM..SQ....Q.GMMQQQ................PQQ.......QPQqqvqfqnfQNQYQQ
 2325- 2365 (71.89/19.83)	QQQQQGMQQQG.GAGV....GVGVGVG......................M..AP....N.....QQ.................QQGnMMGNFNP...........Q.M.
 2366- 2399 (42.15/ 8.64)	....Q.Q....................ANRNNP...DfMTA....A..AV..AQ....Q.Q..QQQ................QQRG.VPG.............G..MMA
 2400- 2463 (82.20/23.71)	GNRGQYMNQAP.NVTM....SNMMGPGPGQVPPyarQ.QAA....G.gGK..PG....V.LNTQQQ................FQQQ.QQQQLRHQ..........QMMQ
 2464- 2529 (90.16/26.71)	MQGMGGGGGGGMGAGPqqagGAG.GVGGGGGGV...G.VGV....G..GM.vPQ....Q.QSMNQQ................QTPN.LVAQLQ.R........QNMMGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      13|      16|    1942|    1956|       2
---------------------------------------------------------------------------
 1942- 1956 (21.68/10.76)	PKTPPvnNQTQQPQL
 1960- 1972 (28.37/ 9.61)	PQQPP..NVQQQQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.51|      35|      47|    1757|    1794|       3
---------------------------------------------------------------------------
 1757- 1794 (53.98/48.75)	DDKKNYLNLMKKLKKEIGEKNNASirvIRQLLPLYKQP
 1806- 1840 (62.53/47.26)	DTKGNKICDMDKKQLRISDKQRIS...VWDILEGHKNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.85|      24|     871|     200|     223|       4
---------------------------------------------------------------------------
  200-  223 (45.36/26.23)	EYYQQ....SHDKNNSNSSNQPSITAPG
 1073- 1100 (40.49/22.50)	EYYQQlqciKRFKDIFNTPEQLSLPPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.34|      12|      15|    1102|    1113|       5
---------------------------------------------------------------------------
 1102- 1113 (21.14/11.69)	NPQLLQELFVAP
 1120- 1131 (24.20/14.60)	EPHWLRTLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.64|      26|     444|     968|     993|       7
---------------------------------------------------------------------------
  968-  993 (44.05/32.90)	SLLELCDSLLKELPEVEHQLQ..LKKSN
 1415- 1442 (38.59/27.70)	SLLEFAQAVLKQICAQEHVLErcLKNAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.50|      40|     871|     599|     639|       8
---------------------------------------------------------------------------
  599-  639 (66.06/46.52)	EPKQDKDTVRI...LCEWAVSgQRWGEHRAMVVASLLDKRQIDV
 1477- 1519 (63.44/39.61)	ELDQKAMIVRIlenLGQWTLR.ISWLDLQLMYRQSLSNNAELNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      14|      15|    1279|    1292|       9
---------------------------------------------------------------------------
 1279- 1292 (25.24/15.04)	YSVSTSPNPLHAVG
 1295- 1308 (24.99/14.81)	FSIRLSCDRHLLVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24972 with Med12 domain of Kingdom Metazoa
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