<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24970

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPTPLPLPLEQMPGVGGGGGGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKSDMERKVEIYDYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPEEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIQNGRVTFEVKHEFSVALTVMGDSPTVPWRLLDIDVLVEDKETGDGKALVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYDRLDENNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGPKGTAEVADRAVRSEHLSMERLIVHTVYIRSVGRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQVHITIDTHTGMFRCHVPKHLDCPITDEMQDCLNGDRGKLPALLSELRYWITHRRCEKTLQHLPATATETLPFLVQPDQELLQPGRHKIYVKLHRHPNIVLVVQLKEKTTMPNEMEYTFHLGFVAFQKDELDVIDDSAKQLVSVVAQPPSDIPKFYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFSSQQQQQQQQGGPSAAAGESKTSGASALPKIEPHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFFRTPLQSSHQKEQGSRRTVYLNYEQANHDFSKTVEDLLNDWSKIVYLYTLVHDFAEQLKNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPLSSVAKLPVLPFLGIPRPQVPVLSFCMLAQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEDITPIQGLKAFLSKYVDESAAYRSRAAHEDDNPLSPMGMEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGADRAGSRGTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVPDMSPLERFLGCVYMRRQLHRNIQNEEALTALNSTEPGVVLFKVDGLQCQVVLNQIHMQTLHLKISHLPPMPDKLPPPFQLSPDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPVQVLKDFVQIMRLELKPELGGDQLKWTVQMCMRMPPSAVPIVPIGNTCVVLGRMKILFFLQITRIQYGGGVGGPKDWKDSPSLVLPIVYDIQTNITQMAERNGQVTSPTMTAASTLLRRFAEFNAQQNQCSLFPAITDLLTNLQLATEMPQPPPNQSIGPPVGVGVGVGVGVGVGVGVVGSSPNPMMPMQQLQPQQVGPQGPVGPGGYPQMGPNPGGPQ
Length1571
PositionTail
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.265
Instability index53.14
Isoelectric point8.37
Molecular weight173706.66
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24970
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     193.95|      40|      40|    1044|    1083|       1
---------------------------------------------------------------------------
 1044- 1074 (53.99/15.96)	....................PFL....GTGMRGP.....Q........SPRDSGLR..FPA....PHTP..PSSSN
 1075- 1117 (49.07/13.92)	PHTPASP.HP.............saggGGGGSGA.....QghgnfnltSP.........PA....PHMP.hPSPSG
 1120- 1171 (44.19/11.89)	PSSPLNP.QP.........sPHM.....VHSPGPntlymQ........SHQDSPFTamSPAnnnwPGSPsmPRPS.
 1172- 1221 (46.70/12.93)	PRPGQSPeHKstgggaggagGAD....RAGSRGT.....L........N.RPWAGA..VPT....LLTH..EALET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.56|      16|      23|     787|     804|       2
---------------------------------------------------------------------------
  787-  804 (20.56/24.71)	VYLnYEQAnHDFSKTVED
  813-  828 (29.00/20.57)	VYL.YTLV.HDFAEQLKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.57|      80|     366|     875|     996|       3
---------------------------------------------------------------------------
  875-  954 (141.40/145.03)	VGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPLSSVAKLPVLPFLGIPRPQV..PVLSFCMLAQSPCL.MRLTYQ
 1360- 1442 (129.17/67.93)	VQIMRLELKPELGGDQLKWTVQMCMRMPPSAVPIVPIGNTCVVLGRMKILFFLQITRIQYggGVGGPKDWKDSPSLvLPIVYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.36|      18|     366|     975|     996|       4
---------------------------------------------------------------------------
  975-  993 (25.74/23.59)	ASSRfERNVVEDITPIQGL
 1005- 1022 (32.62/14.90)	AAYR.SRAAHEDDNPLSPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.71|      20|     366|     234|     256|       5
---------------------------------------------------------------------------
  234-  253 (30.39/21.60)	RLLDIDVLVEDKETGDGKAL
  258-  277 (31.32/12.97)	QVNYIHQLIQARLVENPNAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.52|      12|     366|      43|      56|       6
---------------------------------------------------------------------------
   43-   55 (18.45/19.38)	I.DFiIQRTYHELT
   73-   85 (18.07/ 6.45)	IyDY.AARTRHLFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.75|      14|      23|     153|     166|       7
---------------------------------------------------------------------------
  153-  166 (26.14/18.09)	TYNRLPTCIRERIV
  179-  192 (23.62/15.54)	TLLRLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      15|      23|     829|     844|       8
---------------------------------------------------------------------------
  829-  844 (22.51/21.19)	KRLSlCDML.VVKSYSY
  855-  870 (23.38/16.05)	KEVS.CNIYwSVQSHGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.89|      16|      28|     287|     302|       9
---------------------------------------------------------------------------
  287-  302 (27.22/17.32)	FCQSLQLEVLYTQTLR
  318-  333 (28.67/18.63)	YVPGVKLTVSYWRDLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.76|      22|      30|     454|     477|      11
---------------------------------------------------------------------------
  454-  477 (37.10/30.77)	HLDCPITdeMQDCLNGDRGKLPAL
  487-  508 (39.66/25.73)	HRRCEKT..LQHLPATATETLPFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.49|      12|      27|     721|     737|      12
---------------------------------------------------------------------------
  721-  737 (15.38/21.15)	SKTSGASALpkiepHVW
  751-  762 (22.11/12.42)	SQTNKNSQV.....RIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.66|      58|     192|    1256|    1318|      17
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 1256- 1318 (90.19/65.45)	RNIQ.NEEALTALNSTEPGVVLFKVDGLQCQVVLNQIHMQTlHLKIShlPPMPDklPPPFQ.LSP
 1453- 1512 (94.47/53.45)	RNGQvTSPTMTAASTLLRRFAEFNAQQNQCSLFPAITDLLT.NLQLA..TEMPQ..PPPNQsIGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24970 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VGSSPNPMMPMQQLQPQQVGPQGPVGPGGYPQMGPNPGGPQ
2) YRSRAAHEDDNPLSPMGMEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGADRAGSRGTLNRPWAGAVP
1531
1007
1571
1211










Molecular Recognition Features






MoRF SequenceStartStop




NANANA