Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MNPLDKIHALDEIEKEIILCMQSAGQALQELGKEKSSQKNAETQSQQFLKSLSSVESKLSEQINYLTQVSTGQPHEGSGYASAKVLQMAWHRIQHARSRVRELEETKAKHSHAARQQQKRQQEHAAAQQQQQQQQQQQQQQQQQQQAAQQQQSSGSSGGVGAAGGGDHPMGGDNSMSTN |
Length | 179 |
Position | Head |
Organism | Drosophila ananassae (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora. |
Aromaticity | 0.02 |
Grand average of hydropathy | -1.167 |
Instability index | 77.97 |
Isoelectric point | 7.11 |
Molecular weight | 19751.37 |
Publications | PubMed=17994087 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblMetazoa |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:EnsemblMetazoa |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:EnsemblMetazoa |
Binary Interactions |
Repeats | >MDP24969 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.99| 15| 15| 116| 130| 1 --------------------------------------------------------------------------- 116- 130 (27.78/ 7.49) QQQKRQQEHAAAQQQ 132- 146 (29.21/ 8.22) QQQQQQQQQQQQQQQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ELEETKAKHS 2) QQEHAAAQQ 3) QQQQQQQQQQQQQQAAQQQQSSGSSGGVGAAGGGDHPMGGDNSMSTN | 102 121 133 | 111 129 179 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab