<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24967

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVMEERPNALSDPLKDPILRSYSRCIQADMLCVWRRVQSTKQDNTDPNALTYEITTSTKIHPPLSLAAAKELWIFWYGEEPDLSELVDADLLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASAPPGSAAPGAAGGAGGPQPSQEPAQNGPAMDEAGEGGAAKVTPPAHPRKVMLAPFGIAAILTGNSYKANDPMAEKILEDWASFFPLCNKDNTDLPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEHMAELQKMQMHNAAGHGGSEASLSCPPVAGAAAGPVPGAPGTAAVPVGPASASASAKEASTRKTAPQVVSALERLSFQPYYDQRPTSGFTFNTNNTHIPATAAVEMPERTWQDCIMNTLHVDAAAAAAAAAASSRSTGPEASAAGEEEDSKQQVQQQLQQQQQQQQQRHKLWNFVDPMQKAPCTCTNAQCISHHNNNNNNSGNIKRQQQPLGSPALRTAVANASGNKSSYQQHYHQQHLHQQLQQQQQQRPGTPVSVAGATTSSHHSSSSSSYSSSSSSLSNTSTFNSSASAVRRHNVPFHKRLSATSATATATFRSKTNNNNNNNNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPPEQMLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYADHATGGGTGGSGSGGGATGTGPGSVPAQQPATPTAAAVPSAGAGSASGGAGSVGTISVKKLEMQQKQPPLTAAMAIKQEPGIAAERGGASGGGAASTAEAIQNLLSLYKPPQLTLKDEDSYYDEDWLKELYNFQCQENWDYLPVKRPKLEDTNKQRRPRYAKDLYEGHTHVKPLMPSPGSVYGSQLLSLDVQSNATGGGGAGTGGSGGTSGGLVGIANSNANGSDAENESGNSFFQGLDIKTEPGLHSPTKTSSGGGGGGSGGGSGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSTVTNTIDELKRSTAISTNALVAAAAAAAAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTSTSCISNSACITSSNTTIVSNNNNNSNVTINATTTTSSIILAAIQAPVAVVNVTKLVKQEYNLELGSPVEEAIDNWNYVYRPPQQEKFVGASKYAPLTNLPSQALPPLNIPPGCFYQPTWSSHKSRAATLAKAAAAQKQQHQKHQALQQRIQLHQQKLQQHQHQNHHQQQQQQQQQKHQHQQLHELLSAAPRTPMTPTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQMMRAGMSPISPGPGVVPFPRSSPMMRQTPTHPPPPYPYELAVASPATSTSSYLNRPLHSQEHQGMGGGGMGVGGMGAPGGGMSMMPYTGDAGISSGNSAAAVASSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGASFNPFPAGGGQRLLNGPAASFGGLRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGLADDPGRNKQPTLLSLIQSLCRKNQIKQAPGEPSSALEKAGSGGGAGATAGQLEHLAHAIFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRHRRIFGTNGAPTASRASIANVLEFIDAHDVVSLALEQARLAFENNMMDFHGNGSSTFQAFHAPPPALRHKLAGIGGGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQSAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNDHVANSTRTYFRELSSTYEMCKLGRHTPIRGWDGILQVGAARNPAAADREATPLDEWLRSLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGTGNSGNTKGGSSLTPNLSAATGLPGGDLATDNIKLEPGTEPPPVEANAEVKQEPGTGKPGAAGADTKPALILGDPLGVGETLEDINPPAIVLYVVNPFTFGSDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGLISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVEDDFLTFEEEGNEDFDDADMNDLFWDPPMDKTSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQTADDILNSTNAHQSANDHPLDSILTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2728
PositionMiddle
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.447
Instability index52.87
Isoelectric point6.30
Molecular weight292336.39
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP24967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     137.05|      28|      80|     503|     530|       1
---------------------------------------------------------------------------
  503-  523 (28.15/10.40)	.......ASAAGEEEDS.KQ.QVQQQ.LQQQ
  583-  604 (30.36/11.75)	.......ANASGNKSSY.QQ.HYHQQhLHQQ
 1340- 1357 (23.57/ 7.60)	.......AAAAQKQ....QH.QKHQA.LQQR
 1358- 1376 (32.12/12.83)	IQLHQQK..........lQQ.HQHQN.HHQQ
 1377- 1391 (22.86/ 7.16)	QQQQQQQ.............kHQHQQ.LH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     909.88|     127|     670|     736|     862|       2
---------------------------------------------------------------------------
  176-  278 (67.61/18.54)	...................................................................................................QPCTSS....DRLFGRSS...QhlSFSFTFF.......................VHG.DT...VCASI...DL...............REHPAVRPLtkehlaeaaaAFA.......................AASAPPG...SAAP.GAAG.GAGGPQPSQEPA....QN...gPAM....DEAgeggAAK....VT
  280-  432 (111.07/35.08)	PAHPRKvmlAPFGIAAiltgNSYKANDPM.AEKILeDWASFFPlCNK.........................DN.......................TDLP..PV....VEVVSGGH...K..MYHPTNYvlvtdlddmehmehmaelqkmqmHN.........AAG...HG...............GSEASLSCP..........PVA.......................GAAAGPV...PGAP.GTAA.VPVGPASASASA....KE....AST...rKTA....PQV....VS
  554-  676 (34.73/ 6.03)	..........SHHNNN....NNNSGNIKR.QQQPL.G.SPALR.TAVanasgnkssyqqhyhqqhlhqqlqqQQ.......................QQRPGTPV..........SV...A..GATTSSH.......................HSS.SSssySSSSS...SLsntstfnssasavrrHNVPFHKRL..........S.A.......................TSATATA...T......................................................
  736-  861 (216.98/75.39)	PATPAP...SPHPNSA....HSQPTSVPP.PEQML.NMSPHAP.TSV.........................SN.......................LQQPPTPI....DHLLDKNT...P..APTPTDQ.......................HDS.KS...ITASP...YV...............HQTPSVEPP..........SYA.......................DHATGGG...TGGS.GSGG.GATGTGPGSVPA....QQ....PAT....PTA....AAV....P.
  862-  919 (51.03/12.23)	.........SAGAGSA....SGGAGSVGTiSVKKL.EMQQKQP...................................................................................................................P...LTAAM...AI...............KQEPGI...............A.........................AERGG........ASGG.GAAST........................................
  931- 1037 (68.41/18.85)	.........KP.PQLT....LKDEDSYYD.EDWLK.ELYNFQC.Q...........................EN.......................WDYLPVKR....PKLEDTNKqrrPryAKDLYEG.......................HTHvKP...LMPSPgsvYG...............SQLLSLDVQ..........S..........................NATGGGgagTGGSgGTSG.GLVG.........................................
 1038- 1126 (47.18/10.76)	.................................................................................................................IANS...N..ANGSDAE.......................NESgNS...FFQGL...DI...............KTEPGLHSP..........TKT.......................SSGGGGG...GSGG.GSGG.GNLFTAEGLNPSlndlEQlfetSSN....DEC....SSVqihtPP
 1398- 1539 (138.60/45.56)	PRTPMT...PTVP.........QPLSSGG.SQLLL.NQL.NCP.......................................................QAPPGSS....MQQMMRAG...M..SPISPGP.......................GVV.PF...PRSSP...MM...............RQTPTHPPP..........PYPyelavaspatstssylnrplhsqEH.QGMG...GGGM.GVGGmGAPGGGMSMMPY....TG....DAGissgNSA....AAV....AS
 1543- 1643 (87.02/25.93)	........................QELPE.VNSVL.....................................VN.......................ILLYDTALnvfrDHNFDSSS...V..CVCNADT.......................QKI.GN...IRGAD...SG...............VYVP.LPGA..........SFN.......................PFPAGGG...Q..R.LLNG.PAASFGGLRMIS....AF....GGS....PAS....ASM....PG
 1647- 1760 (87.26/26.02)	GHGHGP...NGGSNSS.........SCTP.P.....SSNPHIT.GYV.........................DDdpvectcgfsavvnrrlshraglFYEDEVEI....TGLADDPG...R..NKQPTLL.......................SLI.QS...LCRKN...QI...............KQAPG.EPS..........SAL.......................EKA............GSGG.GA.GATAG.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.50|      15|     669|     479|     494|       3
---------------------------------------------------------------------------
  479-  494 (20.12/13.79)	NTLhVDAAAAAAAAAA
 1141- 1154 (20.42/ 8.80)	NT..IDELKRSTAIST
 1155- 1166 (18.96/ 7.69)	NAL....VAAAAAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.36|      52|     165|    2465|    2517|       4
---------------------------------------------------------------------------
 2465- 2517 (88.41/56.02)	PTILSACLVTLEPDAKLRVmPDQFTPDERF.SQISMQNPLSTPQD.VTCTHILVF
 2633- 2686 (78.95/45.12)	PHLEDVCPVFLKTALHLHV.PSIQTADDILnSTNAHQSANDHPLDsILTADVLRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.28|      19|     578|     694|     717|      17
---------------------------------------------------------------------------
  694-  712 (38.47/13.79)	TNIPKQRHLGNTPHGTPHG
 1305- 1320 (29.29/15.14)	TNLPSQ...ALPPLNIPPG
 2091- 2107 (25.52/ 7.74)	..VPNDKTLLNPPDGTGNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24967 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAASSRSTGPEASAAGEEEDSKQQVQQQLQQQQQQQQQRHKLWN
2) ASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGY
3) CTNAQCISHHNNNNNNSGNIKRQQQPLGSPALRTAVANASGNKSSYQQHYHQQHLHQQLQQQQQQRPGTPVSVAGATTSSHHSSSSSSYSSSSSSLSNTSTFNSSASAVRRHNVPFHKRLSATSATATATFRSKTNNNNNNNNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPPEQMLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYADHATGGGTGGSGSGGGATGTGPGSVPAQQPATPTAAAVPSAGAGSASGGAGSVGTISVKKLEMQQKQPPLTAAMAIKQEPGIAAERGGASGGGAAS
4) DDADMNDLFWDPPMDKTSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSL
5) HMEHMAELQKMQMHNAAGHGGSEASLSCPPVAGAAAGPVPGAPGTAAVPVGPASASASAKEASTRKTAPQVV
6) QAEDLTKMFPTPPSHEQQHPNSSPCQTDVV
7) QSNATGGGGAGTGGSGGTSGGLVGIANSNANGSDAENESGNSFFQGLDIKTEPGLHSPTKTSSGGGGGGSGGGSGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSTVTNTID
8) RAATLAKAAAAQKQQHQKHQALQQRIQLHQQKLQQHQHQNHHQQQQQQQQQKHQHQQLHELLSAAPRTPMTPTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQMMRAGMSPISPGPGVVPFPRSSPMMRQTPTHPPPPYPYELAVAS
9) SAAPGAAGGAGGPQPSQEPAQNGPAMDEAGEGGAAKVTPPA
10) TSSYLNRPLHSQEHQGMGGGGMGVGGMGAPGGG
11) VKRPKLEDTNKQRRPRYAKDLYEGHTHVKPLMPSPG
12) VPNDKTLLNPPDGTGNSGNTKGGSSLTPNLSAATGLPGGDLATDNIKLEPGTEPPPVEANAEVKQEPGTGKPGAAGADT
487
1639
547
2552
360
1170
1014
1333
241
1484
966
2091
535
1673
918
2605
431
1199
1144
1479
281
1516
1001
2169










Molecular Recognition Features






MoRF SequenceStartStop




NANANA