<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24967

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVMEERPNALSDPLKDPILRSYSRCIQADMLCVWRRVQSTKQDNTDPNALTYEITTSTKIHPPLSLAAAKELWIFWYGEEPDLSELVDADLLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASAPPGSAAPGAAGGAGGPQPSQEPAQNGPAMDEAGEGGAAKVTPPAHPRKVMLAPFGIAAILTGNSYKANDPMAEKILEDWASFFPLCNKDNTDLPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEHMAELQKMQMHNAAGHGGSEASLSCPPVAGAAAGPVPGAPGTAAVPVGPASASASAKEASTRKTAPQVVSALERLSFQPYYDQRPTSGFTFNTNNTHIPATAAVEMPERTWQDCIMNTLHVDAAAAAAAAAASSRSTGPEASAAGEEEDSKQQVQQQLQQQQQQQQQRHKLWNFVDPMQKAPCTCTNAQCISHHNNNNNNSGNIKRQQQPLGSPALRTAVANASGNKSSYQQHYHQQHLHQQLQQQQQQRPGTPVSVAGATTSSHHSSSSSSYSSSSSSLSNTSTFNSSASAVRRHNVPFHKRLSATSATATATFRSKTNNNNNNNNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPPEQMLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYADHATGGGTGGSGSGGGATGTGPGSVPAQQPATPTAAAVPSAGAGSASGGAGSVGTISVKKLEMQQKQPPLTAAMAIKQEPGIAAERGGASGGGAASTAEAIQNLLSLYKPPQLTLKDEDSYYDEDWLKELYNFQCQENWDYLPVKRPKLEDTNKQRRPRYAKDLYEGHTHVKPLMPSPGSVYGSQLLSLDVQSNATGGGGAGTGGSGGTSGGLVGIANSNANGSDAENESGNSFFQGLDIKTEPGLHSPTKTSSGGGGGGSGGGSGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSTVTNTIDELKRSTAISTNALVAAAAAAAAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTSTSCISNSACITSSNTTIVSNNNNNSNVTINATTTTSSIILAAIQAPVAVVNVTKLVKQEYNLELGSPVEEAIDNWNYVYRPPQQEKFVGASKYAPLTNLPSQALPPLNIPPGCFYQPTWSSHKSRAATLAKAAAAQKQQHQKHQALQQRIQLHQQKLQQHQHQNHHQQQQQQQQQKHQHQQLHELLSAAPRTPMTPTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQMMRAGMSPISPGPGVVPFPRSSPMMRQTPTHPPPPYPYELAVASPATSTSSYLNRPLHSQEHQGMGGGGMGVGGMGAPGGGMSMMPYTGDAGISSGNSAAAVASSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGASFNPFPAGGGQRLLNGPAASFGGLRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGLADDPGRNKQPTLLSLIQSLCRKNQIKQAPGEPSSALEKAGSGGGAGATAGQLEHLAHAIFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRHRRIFGTNGAPTASRASIANVLEFIDAHDVVSLALEQARLAFENNMMDFHGNGSSTFQAFHAPPPALRHKLAGIGGGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQSAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNDHVANSTRTYFRELSSTYEMCKLGRHTPIRGWDGILQVGAARNPAAADREATPLDEWLRSLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGTGNSGNTKGGSSLTPNLSAATGLPGGDLATDNIKLEPGTEPPPVEANAEVKQEPGTGKPGAAGADTKPALILGDPLGVGETLEDINPPAIVLYVVNPFTFGSDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGLISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVEDDFLTFEEEGNEDFDDADMNDLFWDPPMDKTSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQTADDILNSTNAHQSANDHPLDSILTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2728
PositionMiddle
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.447
Instability index52.87
Isoelectric point6.30
Molecular weight292336.39
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     137.05|      28|      80|     503|     530|       1
---------------------------------------------------------------------------
  503-  523 (28.15/10.40)	.......ASAAGEEEDS.KQ.QVQQQ.LQQQ
  583-  604 (30.36/11.75)	.......ANASGNKSSY.QQ.HYHQQhLHQQ
 1340- 1357 (23.57/ 7.60)	.......AAAAQKQ....QH.QKHQA.LQQR
 1358- 1376 (32.12/12.83)	IQLHQQK..........lQQ.HQHQN.HHQQ
 1377- 1391 (22.86/ 7.16)	QQQQQQQ.............kHQHQQ.LH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     909.88|     127|     670|     736|     862|       2
---------------------------------------------------------------------------
  176-  278 (67.61/18.54)	...................................................................................................QPCTSS....DRLFGRSS...QhlSFSFTFF.......................VHG.DT...VCASI...DL...............REHPAVRPLtkehlaeaaaAFA.......................AASAPPG...SAAP.GAAG.GAGGPQPSQEPA....QN...gPAM....DEAgeggAAK....VT
  280-  432 (111.07/35.08)	PAHPRKvmlAPFGIAAiltgNSYKANDPM.AEKILeDWASFFPlCNK.........................DN.......................TDLP..PV....VEVVSGGH...K..MYHPTNYvlvtdlddmehmehmaelqkmqmHN.........AAG...HG...............GSEASLSCP..........PVA.......................GAAAGPV...PGAP.GTAA.VPVGPASASASA....KE....AST...rKTA....PQV....VS
  554-  676 (34.73/ 6.03)	..........SHHNNN....NNNSGNIKR.QQQPL.G.SPALR.TAVanasgnkssyqqhyhqqhlhqqlqqQQ.......................QQRPGTPV..........SV...A..GATTSSH.......................HSS.SSssySSSSS...SLsntstfnssasavrrHNVPFHKRL..........S.A.......................TSATATA...T......................................................
  736-  861 (216.98/75.39)	PATPAP...SPHPNSA....HSQPTSVPP.PEQML.NMSPHAP.TSV.........................SN.......................LQQPPTPI....DHLLDKNT...P..APTPTDQ.......................HDS.KS...ITASP...YV...............HQTPSVEPP..........SYA.......................DHATGGG...TGGS.GSGG.GATGTGPGSVPA....QQ....PAT....PTA....AAV....P.
  862-  919 (51.03/12.23)	.........SAGAGSA....SGGAGSVGTiSVKKL.EMQQKQP...................................................................................................................P...LTAAM...AI...............KQEPGI...............A.........................AERGG........ASGG.GAAST........................................
  931- 1037 (68.41/18.85)	.........KP.PQLT....LKDEDSYYD.EDWLK.ELYNFQC.Q...........................EN.......................WDYLPVKR....PKLEDTNKqrrPryAKDLYEG.......................HTHvKP...LMPSPgsvYG...............SQLLSLDVQ..........S..........................NATGGGgagTGGSgGTSG.GLVG.........................................
 1038- 1126 (47.18/10.76)	.................................................................................................................IANS...N..ANGSDAE.......................NESgNS...FFQGL...DI...............KTEPGLHSP..........TKT.......................SSGGGGG...GSGG.GSGG.GNLFTAEGLNPSlndlEQlfetSSN....DEC....SSVqihtPP
 1398- 1539 (138.60/45.56)	PRTPMT...PTVP.........QPLSSGG.SQLLL.NQL.NCP.......................................................QAPPGSS....MQQMMRAG...M..SPISPGP.......................GVV.PF...PRSSP...MM...............RQTPTHPPP..........PYPyelavaspatstssylnrplhsqEH.QGMG...GGGM.GVGGmGAPGGGMSMMPY....TG....DAGissgNSA....AAV....AS
 1543- 1643 (87.02/25.93)	........................QELPE.VNSVL.....................................VN.......................ILLYDTALnvfrDHNFDSSS...V..CVCNADT.......................QKI.GN...IRGAD...SG...............VYVP.LPGA..........SFN.......................PFPAGGG...Q..R.LLNG.PAASFGGLRMIS....AF....GGS....PAS....ASM....PG
 1647- 1760 (87.26/26.02)	GHGHGP...NGGSNSS.........SCTP.P.....SSNPHIT.GYV.........................DDdpvectcgfsavvnrrlshraglFYEDEVEI....TGLADDPG...R..NKQPTLL.......................SLI.QS...LCRKN...QI...............KQAPG.EPS..........SAL.......................EKA............GSGG.GA.GATAG.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.50|      15|     669|     479|     494|       3
---------------------------------------------------------------------------
  479-  494 (20.12/13.79)	NTLhVDAAAAAAAAAA
 1141- 1154 (20.42/ 8.80)	NT..IDELKRSTAIST
 1155- 1166 (18.96/ 7.69)	NAL....VAAAAAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.36|      52|     165|    2465|    2517|       4
---------------------------------------------------------------------------
 2465- 2517 (88.41/56.02)	PTILSACLVTLEPDAKLRVmPDQFTPDERF.SQISMQNPLSTPQD.VTCTHILVF
 2633- 2686 (78.95/45.12)	PHLEDVCPVFLKTALHLHV.PSIQTADDILnSTNAHQSANDHPLDsILTADVLRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.28|      19|     578|     694|     717|      17
---------------------------------------------------------------------------
  694-  712 (38.47/13.79)	TNIPKQRHLGNTPHGTPHG
 1305- 1320 (29.29/15.14)	TNLPSQ...ALPPLNIPPG
 2091- 2107 (25.52/ 7.74)	..VPNDKTLLNPPDGTGNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24967 with Med13 domain of Kingdom Metazoa
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