<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24966

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGAKSSGTGFGSHIPSIEEKNKQIQQETMMEKLRAKHRNKPRSYEEIKKSVRMYFIEKHYPLDPLCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQMLFISTDMFYVEILLDAAGSLLDVKVHHECKIEQQSSELVDCLKAGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIHSLYQMHLQSQSGNSYDLMASSPVGLVLPRRGGHPMKLTYFCPPLHLPEHDPKLPSGDFTIEQVMRSSYGLNATVNLEGSSANKLQVAPILSFVRDQQTGMEVPTYAPLNQTNSLLMPATYVLRLNKPMPVCVESLKALGLPGLDAQANPPTPATTVLNLIVQTASKQAIRNTQRGLYVNLPKETHCYFFTDNRRLQGTLVSSLPFTEPAQVPRIVAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQPTCSVFCLSNEYEALSQKLTRTVRQVVSIPMVIYKLLKCWDEEHDFKLHGVMNPGTGAAGGGSVGGGGSVGSGSSTSGGGGFNQFAMDTAQPPDGNLPGGSFANISNLKIDAKSRSLADAFAASTSAAAAIAGLINLKRETDPQASSSSASSSSSVSTSSSVSKSSDQEIADKYKNIWKDKTPNLKHCVSITPIPGDGKSGSGAGGLSGVEVQRTGGIEIIPLNTQASTSGGGAAGGGTSSAPTTITITPITGKDPGKESSKKSSSSVSGTNMATKRPHESSSSSSSGASGSSSSSAGSSSSSDMQKEKKRKKKRDDSPMGPPEKIYSRQNSPAAGGDASGSSGVVRKFSSPSSSPKAGGAGQGLMAGVPPARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATSLSPKGDKTSSSVGASSVSSSSSASGVGSAPGLVRSFASVGAPPPPPPVPPLASASGNSGQSMKKEKSSSASGSSSSSSTSAAVGSTGSGGVGGGGGGSGISASLAAAVAALKSSQAQQQQLKTSVASLSHSSAGGGGLGSYASSASAGGAASVVGGAVGAGAGASGLELSGLRKGMAGGAVSLMTSTAPLATTIPAPTTQSAATSVSAPGSATAAVVAAAAVAGVSTPTATTAAGATAMLQQPQQPGTAPPSSCLATSGDGGTPAGGGTGASTEYMVKPSSQEGLKLTINKTGSGKSSGSSSSSSSSAGSSTSSSGVPKTKSASGSNISSGSSSKKQHTGLKPGVNSGPASKKASASTSASATGSASKHLFQKANSSGNLSSKLSGSGVGGGLPLTKSNSTNSFQEHSAPKRRPSMGALASGSSSSSGSSGPRKSSSISAGGSGASGAVSPAAHSGSMSQPPPRFDHHTDMMTILQYASPTMAASMEGFIKGLHNKFQIPKLSQRGASSSGSGGGGAATGSGAAGGGGGSGRSTPSGGTEPSPSTTMSVAPSTSTAAALVEPEAKPPAPPPSSAGGDVLLNLSSSAAMPSGDGIDEELLASLAGE
Length1507
PositionMiddle
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.315
Instability index57.22
Isoelectric point9.39
Molecular weight151765.48
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP24966
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1266.95|     265|     280|     705|     984|       3
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  535-  786 (336.57/69.15)	............................AAGGGSVG..GGGSV....GSGSSTSGGGGFNQFAMDTAQPPD.................GNLPGGSFANIS.NLKIDAKSRSLadafaaSTSAAAAIAGlINLKRETDPQASSSSAsssSSVSTSSSVSK.SS.DQEIADKYKNIWKDKTPNlkhcvsitP........IPgDGKSGSGAGGLS.G........VEVQRT.GGIEIIPLNTQ..........A..ST.SG.G.GA.AGGGTS.SAPTTITITPITGKDPGKESSKKSSSSVSGTNMA.....TKRPHESSSSSSSGASGSSSSSAGSS.SSSDMQKEK
  787- 1049 (378.60/79.96)	KRKKKRDD.SP...MGPPEKIYSRQNSPAAGGDASG..SSGVVRKF.SSPSSSPKAGGAGQGLMAGVPPARpspkhspvysspkhnTASNSPKSPFGTHS.PKHGSSGKPSM......STLKSAATAA.TSLSPKGDKTSSSVGA...SSVSSSSSASGVGS.APGLVRSFASVGAPPPPP........P........VP.PLASASGNSGQSMK........KEKSSSASGSSSSSSTSA..........AvgSTgSG.GvGG.GGGGSGiSASLAAAVAALKSSQAQQQQLK...TSVASL..............SHSSAGGGGLGSYASSASA...........
 1050- 1223 (237.04/46.43)	...............GGAASVVG..GAVGAGAGASGleLSGL.RK........GMAGGAVSLMTST...........................APLATTI.P......AP.........TTQSAAT....SVSAPGSATAAVVAA...AAVAGVSTPTAT.T.AAG...ATAMLQQPQQPG........T........AP.P..............................S..S...............C.lAT.SGdG.GTpAGGGT..GASTEYMVKP.SSQEGLKLTINK.....TG.................SGKSSGSSSSSSSSAGSStSSSGVPKTK
 1235- 1499 (314.74/64.17)	SSKKQHTGlKPgvnSGPASKKASASTSASATG..SA..SKHLFQKAnSSGNLSSKLSGSGVG..GGLPL.................TKSNSTNS.FQEHSaPK.R...RPSM......GAL......A.SG.......SSSSSGS...SGPRKSSSISAGGSgASGAVSPAAHSGSMSQPP........PrfdhhtdmMT.ILQYASPTMAASMEgfikglhnKFQIPKLS........QRgasssgsgggG..AA.TG.S.GA.AGGGGG.SGRS....TPSGGTEPSPSTTMSVAPSTS.TAAAlvepeAKPPAPPPSSAGGDVLLNLSSSAAMP.SGDGIDEE.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP24966 with Med1 domain of Kingdom Metazoa
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