<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP24964
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSFHLSTKERLLLLVDDMEMISKELIEQAHQKISSTDLADLLDLLVAKDEELRKMLELADEQAKVEDAMDKLRAKVEVHDREIQKLQKSLKDAESILSTAIFQARQKLASINQANKRPVSSEELIKYAHRISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNLNGGPVTHQNSGMASDQQRNLGGSGSSSGAGASGEVPNAYQNQFNWNLGELHMTMGASGNTVALETRAQDDVEVMSTDSSSSSSSDSQ |
Length | 257 |
Position | Middle |
Organism | Drosophila ananassae (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila> Sophophora.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.540 |
Instability index | 45.29 |
Isoelectric point | 5.05 |
Molecular weight | 28130.12 |
Publications | PubMed=17994087
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblMetazoa
|
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:EnsemblMetazoa
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:EnsemblMetazoa
|
Interaction
Repeat regions
Repeats |
>MDP24964
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 109.52| 31| 31| 25| 55| 1
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12- 43 (39.12/18.88) LLL.VDDMEM............iskeLI.EQAHQKISSTDLADLLD
44- 73 (36.89/17.52) LLV.AKDEELRKM...............lELADEQAKVEDAMDKLR
74- 118 (33.51/15.46) AKVeVHDREIQKLqkslkdaesilstAI.FQARQKLASINQANKRP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.84| 29| 31| 164| 194| 2
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166- 194 (51.96/33.18) SEQNLNGG..PVTHQN..SGMASDQQRNLGGSG
196- 228 (43.88/21.39) SSGAGASGevPNAYQNqfNWNLGELHMTMGASG
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